Glucocorticosteroids in acute alcoholic hepatitis: The evidence of a beneficial effect is getting even weaker

Journal of Hepatology

Volumn 53, Issue 2, 2010, Pages 390-391

  Christensen, Erik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; GLUCOCORTICOID; PENTOXIFYLLINE;

ACUTE DISEASE; ALCOHOL LIVER DISEASE; ARTICLE; CORTICOSTEROID THERAPY; DRUG EFFECT; DRUG MECHANISM; HUMAN; PRIORITY JOURNAL; SURVIVAL; TREATMENT RESPONSE; CHEMICALLY INDUCED; GASTROINTESTINAL HEMORRHAGE; HEPATITIS, ALCOHOLIC; IMMUNOSUPPRESSIVE TREATMENT; TREATMENT OUTCOME;

ACUTE DISEASE; GASTROINTESTINAL HEMORRHAGE; GLUCOCORTICOIDS; HEPATITIS, ALCOHOLIC; HUMANS; IMMUNOSUPPRESSION; TREATMENT OUTCOME;

EID: 77955308282     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.12.045     Document Type: Note

References (10)

1. H.O. Conn Steroid treatment of alcoholic hepatitis. The yeas and the nays Gastroenterology 74 1978 319 322
2. E. Christensen, and C. Gluud Glucocorticoids are ineffective in alcoholic hepatitis: a meta-analysis adjusting for confounding variables Gut 37 1995 113 118
3. E. Christensen Alcoholic hepatitis - glucocorticosteroids or not? J Hepatol 36 2002 547 548
4. A. Rambaldi, H.H. Saconato, E. Christensen, K. Thorlund, J. Wetterslev, and C. Gluud Systematic review: glucocorticosteroids for alcoholic hepatitis - a Cochrane Hepato-Biliary Group systematic review with meta-analyses and trial sequential analyses of randomized clinical trials Aliment Pharmacol Ther 27 2008 1167 1178
5. H.H. Tan, S. Virmani, and P. Martin Controversies in the management of alcoholic liver disease Mt Sinai J Med 76 2009 484 498
6. E.H. Forrest, A.J. Morris, S. Stewart, M. Phillips, Y.H. Oo, and N.C. Fisher The Glasgow alcoholic hepatitis score identifies patients who may benefit from corticosteroids Gut 56 2007 1743 1746
7. A. Louvet, S. Naveau, M. Abdelnour, M.J. Ramond, E. Diaz, and L. Fartoux The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids Hepatology 45 2007 1348 1354
8. P. Mathurin, J. O'Grady, R.L. Carithers, P. Martin, M.-R. Ramond, and A. Louvet Corticosteroids improve 28-day survival in patients with severe alcoholic hepatitis: individual data analysis of the last 5 randomized controlled trials Hepatology 48 2008 S635A
9. E. Christensen, P. Schlichting, P.K. Andersen, L. Fauerholdt, E. Juhl, and H. Poulsen A therapeutic index that predicts the individual effects of prednisone in patients with cirrhosis Gastroenterology 88 1985 156 165
10. A. Louvet, F. Wartel, H. Castel, S. Dharancy, A. Hollebecque, and V. Canva-Delcambre Infection in patients with severe alcoholic hepatitis treated with steroids: early response to therapy is the key factor Gastroenterology 137 2009 541 548