The MerR/NmlR family transcription factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production

Journal of Bacteriology

Volumn 192, Issue 15, 2010, Pages 4063-4066

  Potter, Adam J ^a   Kidd, Stephen P ^a   McEwan, Alastair G ^b   Paton, James C ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; CARBAMOYL PHOSPHATE SYNTHASE; CARBONYL DERIVATIVE; FORMALDEHYDE; HYDROGEN PEROXIDE; MERR PROTEIN; METHYLGLYOXAL; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NMLR; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; DNA BINDING PROTEIN; MERR PROTEIN, BACTERIA; OXYGEN;

AEROBIC METABOLISM; ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; CARBON METABOLISM; CELLULAR STRESS RESPONSE; DOWN REGULATION; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOCOCCUS PNEUMONIAE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MULTIGENE FAMILY; OXIDATIVE STRESS; PHYSIOLOGY;

STREPTOCOCCUS PNEUMONIAE;

ALCOHOL DEHYDROGENASE; BACTERIAL PROTEINS; DNA-BINDING PROTEINS; DOWN-REGULATION; FORMALDEHYDE; GENE EXPRESSION REGULATION, BACTERIAL; HYDROGEN PEROXIDE; MULTIGENE FAMILY; OXIDATIVE STRESS; OXYGEN; PYRUVALDEHYDE; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION FACTORS;

EID: 77955299893     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00383-10     Document Type: Article

References (20)

1. Avery, O. T., C. M. MacLeod, and M. McCarty. 1944. Studies on the chemical nature of the substance inducing transformation of pneumococcal types, induction of transformation by a deoxyribonucleic acid fraction isolated from pneumococcus type III. J. Exp. Med. 79:137-158.
2. Bergeron, Y., N. Ouellet, A. M. Deslauriers, M. Simard, M. Olivier, and M. G. Bergeron. 1998. Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice. Infect. Immun. 66:912-922.
3. Bogaert, D., R. de Groot, and P. W. M. Hermans. 2004. Streptococcus pneumoniae colonisation: the key to pneumococcal disease. Lancet Infect. Dis. 4:144-154.
4. Bringel, F., P. Hammann, V. Kugler, and F. Arsene-Ploetze. 2008. Lactobacillus plantarum response to inorganic carbon concentrations: PyrR(2)-dependent and -independent transcription regulation of genes involved in arginine and nucleotide metabolism. Microbiology 154:2629-2640.
5. Bringel, F., S. Vuilleumier, and F. Arsene-Ploetze. 2008. Low carbamoyl phosphate pools may drive Lactobacillus plantarum CO2-dependent growth phenotype. J. Mol. Microbiol. Biotechnol. 14:22-30.
6. Brown, N. L., J. V. Stoyanov, S. P. Kidd, and J. L. Hobman. 2003. The MerR family of transcriptional regulators. FEMS Microbiol. Rev. 27:145-163.
7. Ferguson, G. P., S. Totemeyer, M. J. MacLean, and I. R. Booth. 1998. Methylglyoxal production in bacteria: suicide or survival? Arch. Microbiol. 170:209-219.
8. Hoffmann, O., J. Zweigner, S. H. Smith, D. Freyer, C. Mahrhofer, E. Dagand, E. I. Tuomanen, and J. R. Weber. 2006. Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide. Infect. Immun. 74:5058-5066.
9. Holden, H. M., J. B. Thoden, and F. M. Raushel. 1999. Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product. Cell. Mol. Life Sci. 56:507-522.
10. Nguyen, T. T., W. Eiamphungporn, U. Mader, M. Liebeke, M. Lalk, M. Hecker, J. D. Helmann, and H. Antelmann. 2009. Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR). Mol. Microbiol. 71:876-894.
11. O'Brien, K. L., L. J. Wolfson, J. P. Watt, E. Henkle, M. Deloria-Knoll, N. McCall, E. Lee, K. Mulholland, O. S. Levine, and T. Cherian. 2009. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 374:893-902.
12. Ogunniyi, A. D., P. Giammarinaro, and J. C. Paton. 2002. The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology 148:2045-2053.
13. Okado-Matsumoto, A., and I. Fridovich. 2000. The role of alpha, beta-dicarbonyl compounds in the toxicity of short chain sugars. J. Biol. Chem. 275:34853-34857.
14. Pesakhov, S., R. Benisty, N. Sikron, Z. Cohen, P. Gomelsky, I. Khozin-Goldberg, R. Dagan, and N. Porat. 2007. Effect of hydrogen peroxide production and the Fenton reaction on membrane composition of Streptococcus pneumoniae. Biochim. Biophys. Acta 1768:590-597.
15. Spellerberg, B., D. R. Cundell, J. Sandros, B. J. Pearce, I. IdanpaanHeikkila, C. Rosenow, and H. R. Masure. 1996. Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae. Mol. Microbiol. 19:803-813.
16. Staab, C. A., M. Hellgren, and J. O. Hoog. 2008. Dual functions of alcohol dehydrogenase 3: implications with focus on formaldehyde dehydrogenase and S-nitrosoglutathione reductase activities. Cell. Mol. Life Sci. 65:3950-3960.
17. Stroeher, U. H., S. P. Kidd, S. L. Stafford, M. P. Jennings, J. C. Paton, and A. G. McEwan. 2007. A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence. J. Infect. Dis. 196:1820-1826.
18. Taniai, H., K. Iida, M. Seki, M. Saito, S. Shiota, H. Nakayama, and S. Yoshida. 2008. Concerted action of lactate oxidase and pyruvate oxidase in aerobic growth of Streptococcus pneumoniae: role of lactate as an energy source. J. Bacteriol. 190:3572-3579.
19. Tettelin, H., V. Masignani, M. J. Cieslewicz, J. A. Eisen, S. Peterson, M. R. Wessels, I. T. Paulsen, K. E. Nelson, I. Margarit, T. D. Read, L. C. Madoff, A. M. Wolf, M. J. Beanan, L. M. Brinkac, S. C. Daugherty, R. T. DeBoy, A. S. Durkin, J. F. Kolonay, R. Madupu, M. R. Lewis, D. Radune, N. B. Fedorova, D. Scanlan, H. Khouri, S. Mulligan, H. A. Carty, R. T. Cline, S. E. Van Aken, J. Gill, M. Scarselli, M. Mora, E. T. Iacobini, C. Brettoni, G. Galli, M. Mariani, F. Vegni, D. Maione, D. Rinaudo, R. Rappuoli, J. L. Telford, D. L. Kasper, G. Grandi, and C. M. Fraser. 2002. Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc. Natl. Acad. Sci. U. S. A. 99:12391-12396.
20. Tseng, H. J., A. G. McEwan, J. C. Paton, and M. P. Jennings. 2002. Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress. Infect. Immun. 70:1635-1639.