Association of p73 G4C14-to-A4T14 polymorphism at exon 2 with the response of human lung adenocarcinoma cell lines to chemotherapy

Cell Biology International

Volumn 34, Issue 2, 2010, Pages 185-188

  Liu, Kaishan ^a   Jiang, Lucen ^b   Zhou, Xulong ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b The People's Hospital of Big Stone   (China)

Author keywords

Chemotherapy; Lung adenocarcinoma; P73 gene; Polymorphism

Indexed keywords

CISPLATIN; PROTEIN P73; ANTINEOPLASTIC AGENT; DNA BINDING PROTEIN; NUCLEAR PROTEIN; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN P73;

5' UNTRANSLATED REGION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DNA EXTRACTION; DRUG SENSITIVITY; GENE EXPRESSION; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG ADENOCARCINOMA; PHARMACOGENETICS; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; EXON; GENETICS; HOMOZYGOTE; LUNG NON SMALL CELL CANCER; LUNG TUMOR; METABOLISM; METASTASIS; NICK END LABELING; PATHOLOGY; TUMOR CELL LINE;

ALLELES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CISPLATIN; DNA-BINDING PROTEINS; EXONS; GENOTYPE; HOMOZYGOTE; HUMANS; IN SITU NICK-END LABELING; LUNG NEOPLASMS; NUCLEAR PROTEINS; POLYMORPHISM, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 77955290150     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20090148     Document Type: Article

References (6)

1. Almeida GM, Duarte TL, Farmer PB, Steward WP, Jones GDD. Multiple end-point analysis reveals cisplatin damage tolerance to be a chemoresistance mechanism in a NSCLC model: Implications for predictive testing. Int J Cancer 2008;122:1810-19.
2. Giachino DF, Ghio P, Regazzoni S, Mandrile G, Novello S, Selvaggi G et al. Prospective assessment of XPD Lys751Gln and XRCC1 Arg399Gln single nucleotide polymorphisms in lung cancer. Clin Cancer Res 2007;13:2876-81.
3. Hu ZB, Miao XP, Ma HX, Tan W, Wang XR, Lu DR et al. Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. Int J Cancer 2005;114: 455-60.
4. Imyanitov EN. Gene polymorphisms, apoptotic capacity and cancer risk. Human Genet 2009;125:239-46.
5. Liu BR, Wei J, Zou ZY, Qian XP, Nakamura T, ZhangW et al. Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. Eur J Hum Genet 2007;15:1049-53.
6. Sullivan A, Syed N, Gasco M, Bergamashi D, Trigiante G, Attard M et al. Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo. Oncogene 2004;23:3328-37.