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This is a great review of the literature on the association between depression and heart disease. It cites important epidemiologic and clinical studies on this subject
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Pozuelo L, Tesar G, Zhang J, et al.: Depression and heart disease: What do we know, and where are we headed? Cleve Clin J Med 2009, 76:59-70. This is a great review of the literature on the association between depression and heart disease. It cites important epidemiologic and clinical studies on this subject.
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Cleve Clin J Med
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This systematic review and meta-analysis reviews the available literature on depression and its risk for poor cardiovascular outcomes, and also calculates such risk
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Van der Kooy K, van Hout H, Marwijk H, et al.: Depression and the risk for cardiovascular diseases: Systematic review and meta analysis. Int J Geriatr Psychiatry 2007, 22:613-626. This systematic review and meta-analysis reviews the available literature on depression and its risk for poor cardiovascular outcomes, and also calculates such risk.
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Scherrer JF, Virgo KS, Zeringue A, et al.: Depression increases risk of incident myocardial infarction among Veterans Administration patients with rheumatoid arthritis. Gen Hosp Psychiatry 2009, 31:353-359.
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Depression and coronary heart disease: Recommendations for screening, referral, and treatment: A science advisory from the american heart association prevention committee of the council on cardiovascular nursing, council on clinical cardiology, council on epidemiology and prevention, and interdisciplinary council on quality of care and outcomes research: Endorsed by the
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Lichtman JH, Bigger JT Jr, Blumenthal JA, et al.: Depression and coronary heart disease: Recommendations for screening, referral, and treatment: A science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: Endorsed by the American Psychiatric Association. Circulation 2008, 118:1768-1775.
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Lichtman, J.H.1
Bigger Jr., J.T.2
Blumenthal, J.A.3
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History of depression and survival after acute myocardial infarction
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This article describes a study evaluating mortality after an MI in ENRICHD participants, particularly comparing the effect of first-episode depression versus recurrent episode of depression. This study found that both predicted shorter survival compared with nondepressed participants, with initial depression episodes being most predictive
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Carney RM, Freedland KE, Steinmeyer B, et al.: History of depression and survival after acute myocardial infarction. Psychosom Med 2009, 71:253-259. This article describes a study evaluating mortality after an MI in ENRICHD participants, particularly comparing the effect of first-episode depression versus recurrent episode of depression. This study found that both predicted shorter survival compared with nondepressed participants, with initial depression episodes being most predictive.
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Carney, R.M.1
Freedland, K.E.2
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Parker GB, Hilton TM, Walsh WF, et al.: Timing is everything: The onset of depression and acute coronary syndrome outcome. Biol Psychiatry 2008, 64:660-666. (Published erratum appears in Biol Psychiatry 2009, 65:449.)
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Parker, G.B.1
Hilton, T.M.2
Walsh, W.F.3
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19
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Psychiatric characteristics associated with long-term mortality among 361 patients having an acute coronary syndrome and major depression: Sevenyear follow-up of SADHART participants
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This excellent article describes findings from a 7-year follow-up of SADHART participants. It highlights characteristics of depression, such as its severity and lack of improvement, that predict greater cardiovascular mortality
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Glassman AH, Bigger JT Jr, Gaffney M: Psychiatric characteristics associated with long-term mortality among 361 patients having an acute coronary syndrome and major depression: Sevenyear follow-up of SADHART participants. Arch Gen Psychiatry 2009, 66:1022-1029. This excellent article describes findings from a 7-year follow-up of SADHART participants. It highlights characteristics of depression, such as its severity and lack of improvement, that predict greater cardiovascular mortality.
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Glassman, A.H.1
Bigger Jr., J.T.2
Gaffney, M.3
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This review focuses on the particularly high risks that treatment-resistant depression places on cardiovascular morbidity and mortality. It reviews relevant studies and considers possible explanations for this relationship
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Carney RM, Freedland KE: Treatment-resistant depression and mortality after acute coronary syndrome. Am J Psychiatry 2009, 166:410-417. This review focuses on the particularly high risks that treatment-resistant depression places on cardiovascular morbidity and mortality. It reviews relevant studies and considers possible explanations for this relationship.
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Carney, R.M.1
Freedland, K.E.2
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Huffman JC, Smith FA, Blais MA, et al.: Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarction. Psychosomatics 2008, 49:309-316.
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Smith, F.A.2
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22
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58149104548
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Psychobiology of depression/ distress in congestive heart failure
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This is an excellent, detailed, and comprehensive review of mechanisms linking depression and congestive heart disease, including autonomic nervous system dysfunction, inflammation and HPA axis activation, platelet dysfunction, and the relationship between mental stress and ischemia
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York KM, Hassan M, Sheps DS: Psychobiology of depression/ distress in congestive heart failure. Heart Fail Rev 2009, 14:35-50. This is an excellent, detailed, and comprehensive review of mechanisms linking depression and congestive heart disease, including autonomic nervous system dysfunction, inflammation and HPA axis activation, platelet dysfunction, and the relationship between mental stress and ischemia.
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Heart Fail Rev
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Parissis JT, Fountoulaki K, Paraskevaidis I, Kremastinos D: Depression in chronic heart failure: Novel pathophysiological mechanisms and therapeutic approaches. Expert Opin Investig Drugs 2005, 14:567-577.
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Expert Opin Investig Drugs
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Parissis, J.T.1
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Kremastinos, D.4
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24
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67651091958
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Elevated depression symptoms predict long-term cardiovascular mortality in patients with atrial fibrillation and heart failure
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This is a substudy of nearly 1000 patients from the AF-CHF trial, which evaluated and found that depression predicts longterm cardiovascular mortality in patients with heart failure and AF receiving optimal medical care
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Frasure-Smith N, Lespérance F, HabraM, et al.: Elevated depression symptoms predict long-term cardiovascular mortality in patients with atrial fibrillation and heart failure. Circulation 2009, 120:134-140. This is a substudy of nearly 1000 patients from the AF-CHF trial, which evaluated and found that depression predicts longterm cardiovascular mortality in patients with heart failure and AF receiving optimal medical care.
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Frasure-Smith, N.1
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25
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Depression and clinical outcomes in heart failure: An OPTIMIZE-HF analysis
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This is a good article summarizing results from a large, prospective, observational study of almost 50,000 heart failure patients from 259 hospitals. It describes how depression in this population unfavorably affects rates of cardiac interventions, length of hospital stay, and post-hospital stay mortality
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Albert NM, Fonarow GC, Abraham WT, et al.: Depression and clinical outcomes in heart failure: An OPTIMIZE-HF analysis. Am J Med 2009, 122:366-373. This is a good article summarizing results from a large, prospective, observational study of almost 50,000 heart failure patients from 259 hospitals. It describes how depression in this population unfavorably affects rates of cardiac interventions, length of hospital stay, and post-hospital stay mortality.
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Albert, N.M.1
Fonarow, G.C.2
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This is a great review on the pathophysiologic link between depression and cardiac illness via platelet activation mechanisms
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Ziegelstein RC, Parakh K, Sakhuja A, Bhat U: Platelet function in patients with major depression. Intern Med J 2009, 39:38-43. This is a great review on the pathophysiologic link between depression and cardiac illness via platelet activation mechanisms.
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Depression and whole blood serotonin in patients with coronary heart disease from the heart and soul study
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Wulsin LR, Musselman D, Otte C, et al.: Depression and whole blood serotonin in patients with coronary heart disease from the Heart and Soul Study. Psychosom Med 2009, 71:260-265.
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This review details current knowledge about depression as a risk factor in patients with coronary artery disease, the implied pathophysiologic pathways, and the effects of antidepressant therapy on CVD outcomes
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Parissis JT, Fountoulaki K, Filippatos G, et al.: Depression in coronary artery disease: Novel pathophysiologic mechanisms and therapeutic implications. Int J Cardiol 2007, 116:153-160. This review details current knowledge about depression as a risk factor in patients with coronary artery disease, the implied pathophysiologic pathways, and the effects of antidepressant therapy on CVD outcomes.
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Int J Cardiol
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van Zyl LT, Lespérance F, Frasure-Smith N, et al.: Platelet and endothelial activity in comorbid major depression and coronary artery disease patients treated with citalopram: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE) biomarker sub-study. J Thromb Thrombolysis 2009, 27:48-56.
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Frasure-Smith N, Lespérance F, Irwin MR, et al.: Depression, Creactive protein and two-year major adverse cardiac events in men after acute coronary syndromes. Biol Psychiatry 2007, 62:302-308.
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Carney RM, Freedland KE, Veith RC: Depression, the autonomic nervous system, and coronary heart disease. Psychosom Med 2005, 67(Suppl 1):S29-S33.
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Joynt KE, Whellan DJ, O'Connor CM: Depression and cardiovascular disease: Mechanisms of interaction. Biol Psychiatry 2003, 54:248-261.
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Whooley MA, de Jonge P, Vittinghoff E, et al.: Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA 2008, 300:2379-2388. This article describes an interesting study of Heart and Soul study patients demonstrating how the relationship between depression and coronary artery disease is largely mediated by behavioral factors such as physical inactivity.
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Depression in coronary artery disease does treatment help?
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Shapiro PA: Depression in coronary artery disease: Does treatment help? Cleve Clin J Med 2008, 75(Suppl 2):S5-S9.
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Cleve Clin J Med
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Shapiro, P.A.1
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50
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0037077490
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Sertraline treatment of major depression in patients with acute MI or unstable angina
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(Published erratum appears in JAMA 2002, 288:1720.)
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Glassman AH, O'Connor CM, Califf RM, et al.: Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA 2002, 288:701-709. (Published erratum appears in JAMA 2002, 288:1720.)
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(2002)
JAMA
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Glassman, A.H.1
O'Connor, C.M.2
Califf, R.M.3
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51
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33644782795
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Onset of major depression associated with acute coronary syndromes: Relationship of onset, major depressive disorder history, and episode severity to sertraline benefit
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Glassman AH, Bigger JT, Gaffney M, et al.: Onset of major depression associated with acute coronary syndromes: Relationship of onset, major depressive disorder history, and episode severity to sertraline benefit. Arch Gen Psychiatry 2006, 63:283-288.
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(2006)
Arch Gen Psychiatry
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, pp. 283-288
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Glassman, A.H.1
Bigger, J.T.2
Gaffney, M.3
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52
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Effects of treating depression and low perceived social support on clinical events after myocardial infarction: The enhancing recovery in coronary heart disease patients (ENRICHD) randomized trial
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Berkman LF, Blumenthal J, Burg M, et al.: Effects of treating depression and low perceived social support on clinical events after myocardial infarction: The Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) randomized trial. JAMA 2003, 289:3106-3116.
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JAMA
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Berkman, L.F.1
Blumenthal, J.2
Burg, M.3
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Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction
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Taylor CB, Youngblood ME, Catellier D, et al.: Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Arch Gen Psychiatry 2005, 62:792-798.
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(2005)
Arch Gen Psychiatry
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Taylor, C.B.1
Youngblood, M.E.2
Catellier, D.3
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54
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Effects of antidepressant treatment following myocardial infarction
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van Melle JP, de Jonge P, Honig A, et al.: Effects of antidepressant treatment following myocardial infarction. Br J Psychiatry 2007, 190:460-466.
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(2007)
Br J Psychiatry
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Van Melle, J.P.1
De Jonge, P.2
Honig, A.3
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55
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33846499596
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Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: The Canadian cardiac randomized evaluation of antidepressant and psychotherapy efficacy (CREATE) trial
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(Published erratum appears in JAMA 2007, 298:40). This article describes results of the CREATE trial, a two-by-two factorial design study evaluating the efficacy of citalopram and/or IPT for treatment of depression in patients with coronary artery disease. It demonstrated efficacy for citalopram but lack of such for IPT
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Lesperance F, Frasure-Smith N, Koszycki D, et al.: Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial. JAMA 2007, 297:367-379. (Published erratum appears in JAMA 2007, 298:40). This article describes results of the CREATE trial, a two-by-two factorial design study evaluating the efficacy of citalopram and/or IPT for treatment of depression in patients with coronary artery disease. It demonstrated efficacy for citalopram but lack of such for IPT.
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(2007)
JAMA
, vol.297
, pp. 367-379
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Lesperance, F.1
Frasure-Smith, N.2
Koszycki, D.3
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56
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33751532748
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Bupropion for smokers hospitalized with acute cardiovascular disease
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Rigotti NA, Thorndike AN, Regan S, et al.: Bupropion for smokers hospitalized with acute cardiovascular disease. Am J Med 2006, 119:1080-1087.
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(2006)
Am J Med
, vol.119
, pp. 1080-1087
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Rigotti, N.A.1
Thorndike, A.N.2
Regan, S.3
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57
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34247240547
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Influence of antidepressants on hemostasis
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Halperin D, Reber G: Influence of antidepressants on hemostasis. Dialogues Clin Neurosci 2007, 9:47-59.
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(2007)
Dialogues Clin Neurosci
, vol.9
, pp. 47-59
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Halperin, D.1
Reber, G.2
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58
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0033977733
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Excess risk of myocardial infarction in patients treated with antidepressant medications: Association with use of tricyclic agents
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Cohen HW, Gibson G, Alderman MH: Excess risk of myocardial infarction in patients treated with antidepressant medications: Association with use of tricyclic agents. Am J Med 2000, 108:2-8.
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(2000)
Am J Med
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Cohen, H.W.1
Gibson, G.2
Alderman, M.H.3
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59
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34648829804
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Treatment of postmyocardial infarction depressive disorder: A randomized, placebocontrolled trial withmirtazapine
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Honig A, Kuyper AM, Schene AH, et al.: Treatment of postmyocardial infarction depressive disorder: A randomized, placebocontrolled trial withmirtazapine. PsychosomMed 2007, 69:606-613.
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(2007)
Psychosom Med
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Honig, A.1
Kuyper, A.M.2
Schene, A.H.3
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60
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56149099474
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Depression screening and patient outcomes in cardiovascular care: A systematic review
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This is a great article providing a systematic review evaluating the benefits of depression screening in patients with cardiac disease by assessing the accuracy of depression screening tools and the effect of depression treatment on depression and cardiovascular morbidity and mortality
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Thombs BD, de Jonge P, Coyne JC, et al.: Depression screening and patient outcomes in cardiovascular care: A systematic review. JAMA 2008, 300:2161-2171. This is a great article providing a systematic review evaluating the benefits of depression screening in patients with cardiac disease by assessing the accuracy of depression screening tools and the effect of depression treatment on depression and cardiovascular morbidity and mortality.
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(2008)
JAMA
, vol.300
, pp. 2161-2171
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Thombs, B.D.1
De Jonge, P.2
Coyne, J.C.3
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61
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34548149895
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Impact of cardiac rehabilitation on depression and its associated mortality
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Milani RV, Lavie CJ: Impact of cardiac rehabilitation on depression and its associated mortality. Am J Med, 2007, 120:799-806.
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(2007)
Am J Med
, vol.120
, pp. 799-806
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Milani, R.V.1
Lavie, C.J.2
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