Alpha-thalassemia is associated with a decreased occurrence and a delayed age-at-onset of albuminuria in sickle cell anemia patients

Blood Cells, Molecules, and Diseases

Volumn 45, Issue 2, 2010, Pages 154-158

  Nebor, Danitza ^a   Broquere, Cédric ^a   Brudey, Karine ^b   Mougenel, Danielle ^b   Tarer, Vanessa ^b   Connes, Philippe ^a,c   Elion, Jacques ^a   Romana, Marc ^a  

^a INSERM   (France)

^b CHU de Pointe a Pitre   (France)

^c UNIVERSITÉ DES ANTILLES ET DE LA GUYANE   (France)

Author keywords

Albuminuria; Alpha thalassemia; Sickle cell anemia

Indexed keywords

ALPHA GLOBIN; HEMOGLOBIN;

ADULT; AGE; AGED; ALBUMINURIA; ALPHA THALASSEMIA; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; ERYTHROCYTE COUNT; FEMALE; GUADELOUPE; HAPLOTYPE; HEMOLYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; PRIORITY JOURNAL; RISK FACTOR; SICKLE CELL ANEMIA; SYSTOLIC BLOOD PRESSURE;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; ALBUMINURIA; ALPHA-THALASSEMIA; ANEMIA, SICKLE CELL; COHORT STUDIES; COMORBIDITY; FEMALE; GUADELOUPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; PREVALENCE;

EID: 77955282543     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2010.06.003     Document Type: Article

References (33)

1. Thomas A.N., Pattison C., Serjeant G.R. Causes of death in sickle-cell disease in Jamaica. Br. Med. J. 1982, 285:633-635.
2. Platt O.S., Brambilla D.J., Rosse W.F., et al. Mortality in sickle cell disease. Life expectancy and risk factors for early death. N. Engl. J. Med. 1994, 330:1639-1644.
3. Guasch A., Cua M., Mitch W.E. Early detection and the course of glomerular injury in patients with sickle cell anemia. Kidney Int. 1996, 49:786-791.
4. Pham P.T., Pham P.C., Wilkinson A.H., Lew S.Q. Renal abnormalities in sickle cell disease. Kidney Int. 2000, 57:1-8.
5. Powars D.R., Elliott-Mills D.D., Chan L., et al. Chronic renal failure in sickle cell disease: risk factors, clinical course, and mortality. Ann. Intern. Med. 1991, 115:614-620.
6. Falk R.J., Scheinman J., Phillips G., et al. Prevalence and pathologic features of sickle cell nephropathy and response to inhibition of angiotensin-converting enzyme. N. Engl. J. Med. 1992, 326:910-915.
7. Aoki R.Y., Saad S.T. Enalapril reduces the albuminuria of patients with sickle cell disease. Am. J. Med. 1995, 98:432-435.
8. Foucan L., Bourhis V., Bangou J., et al. A randomized trial of captopril for microalbuminuria in normotensive adults with sickle cell anemia. Am. J. Med. 1998, 104:339-342.
9. Tan A.S., Quah T.C., Low P.S., Chong S.S. A rapid and reliable 7-deletion multiplex polymerase chain reaction assay for alpha-thalassemia. Blood 2001, 98:250-251.
10. Wang W., Ma E.S., Chan A.Y., et al. Single-tube multiplex-PCR screen for anti-3.7 and anti-4.2 alpha-globin gene triplications. Clin. Chem. 2003, 49:1679-1682.
11. Kéclard L., Romana M., Lavocat E., et al. Sickle cell disorder, beta-globin gene cluster haplotypes and alpha-thalassemia in neonates and adults from Guadeloupe. Am. J. Hematol. 1997, 55:24-27.
12. Guasch A., Navarrete J., Nass K., Zayas C.F. Glomerular involvement in adults with sickle cell hemoglobinopathies: prevalence and clinical correlates of progressive renal failure. J. Am. Soc. Nephrol. 2006, 17:2228-2235.
13. Serjeant G.R., Higgs D.R., Hambleton I.R. Elderly survivors with homozygous sickle cell disease. N. Engl. J. Med. 2007, 356:642-643.
14. Guasch A., Cua M., You W., Mitch W.E. Sickle cell anemia causes a distinct pattern of glomerular dysfunction. Kidney Int. 1997, 51:826-833.
15. Haymann J.P., Stankovic K., Levy P., et al. Glomerular Hyperfiltration in Adult Sickle Cell Anemia: A Frequent Hemolysis Associated Feature. Clin. J. Am. Soc. Nephrol. 2010, 5:756-761.
16. Ljungman S. Microalbuminuria in essential hypertension. Am. J. Hypertens. 1990, 3(12 Pt 1):956-960.
17. Rodicio J.L., Campo C., Ruilope L.M. Microalbuminuria in essential hypertension. Kidney Int. Suppl. 1998, 68:S51-54.
18. Gordeuk V.R., Sachdev V., Taylor J.G., et al. Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency. Am. J. Hematol. 2008, 83:15-18.
19. Guasch A., Zayas C.F., Eckman J.R., et al. Evidence that microdeletions in the alpha globin gene protect against the development of sickle cell glomerulopathy in humans. J. Am. Soc. Nephrol. 1999, 10:1014-1019.
20. Dharnidharka V.R., Dabbagh S., Atiyeh B., et al. Prevalence of microalbuminuria in children with sickle cell disease. Pediatr. Nephrol. 1998, 12:475-478.
21. Embury S.H., Dozy A.M., Miller J., et al. Concurrent sickle-cell anemia and alpha-thalassemia: effect on severity of anemia. N. Engl. J. Med. 1982, 306:270-274.
22. Higgs D.R., Aldridge B.E., Lamb J., et al. The interaction of alpha-thalassemia and homozygous sickle-cell disease. N. Engl. J. Med. 1982, 306:1441-1446.
23. Steinberg M.H., Rosenstock W., Coleman M.B., et al. Effects of thalassemia and microcytosis on the hematologic and vasoocclusive severity of sickle cell anemia. Blood. 1984, 63:1353-1360.
24. Noguchi C.T., Dover G.J., Rodgers G.P., et al. Alpha thalassemia changes erythrocyte heterogeneity in sickle cell disease. J. Clin. Invest. 1985, 75:1632-1637.
25. Fabry M.E., Mears J.G., Patel P., et al. Dense cells in sickle cell anemia: the effects of gene interaction. Blood. 1984, 64:1042-1046.
26. Embury S.H., Clark M.R., Monroy G., Mohandas N. Concurrent sickle cell anemia and alpha-thalassemia. Effect on pathological properties of sickle erythrocytes. J. Clin. Invest. 1984, 73:116-123.
27. Adams R.J., Kutlar A., McKie V., et al. Alpha thalassemia and stroke risk in sickle cell anemia. Am. J. Hematol. 1994, 45:279-282.
28. Castro O., Brambilla D.J., Thorington B., et al. The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease. Blood 1994, 84:643-649.
29. Nolan V.G., Adewoye A., Baldwin C., et al. Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway. Br. J. Haematol. 2006, 133:570-578.
30. Milner P.F., Kraus A.P., Sebes J.I., et al. Sickle cell disease as a cause of osteonecrosis of the femoral head. N. Engl. J. Med. 1991, 325:1476-1481.
31. Gladwin M.T., Sachdev V., Jison M.L., et al. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N. Engl. J. Med. 2004, 350:886-895.
32. Kato G.J., McGowan V., Machado R.F., et al. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood 2006, 107:2279-2285.
33. Nolan V.G., Wyszynski D.F., Farrer L.A., Steinberg M.H. Hemolysis-associated priapism in sickle cell disease. Blood 2005, 106:3264-3267.