Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial

Atherosclerosis

Volumn 211, Issue 2, 2010, Pages 630-637

  Solà, Rosa ^a   Bruckert, Eric ^b   Valls, Rosa Maria ^a   Narejos, Silvia ^c   Luque, Xavier ^c   Castro Cabezas, Manuel ^d   Doménech, Gema ^e   Torres, Ferran ^e   Heras, Mercedes ^a   Farrés, Xavier ^f   Vaquer, José Vicente ^g   Martínez, José Miguel ^h   Almaraz, Maria Cruz ⁱ   Anguera, Anna ^j  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c CAP Centelles ^*  (Spain)

^d Hospital Sant Franciscus Gasthuis   (Netherlands)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f CAP El Remei   (Spain)

^g Centro de Salut Petrer I   (Spain)

^h Centro de Salut Tomás Ortuño   (Spain)

ⁱ HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^j Rottapharmandverbar Madaus   (Spain)

more..

Author keywords

Blood pressure; Cholesterol LDL; Insulin; Oxidised LDL; Soluble fibre

Indexed keywords

APOLIPOPROTEIN B; FATTY ACID BINDING PROTEIN; HERBACEOUS AGENT; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXIDIZED LOW DENSITY LIPOPROTEIN; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR; SIMVASTATIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA POLYMORPHISM; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; LOW FAT DIET; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PATIENT COMPLIANCE; PHASE 4 CLINICAL TRIAL; PLANTAGO OVATA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEED HUSK; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; CHOLESTEROL, LDL; DIETARY FIBER; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; INSULIN; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; PLACEBOS; PLANTAGO; SIMVASTATIN; SYSTOLE; TRIGLYCERIDES;

EID: 77955281425     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.03.010     Document Type: Article

References (23)

1. Graham I., Atar D., Borch-Johnsen K., et al. European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur Heart J 2007, 28:2375-2414.
2. Grundy S.M. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. JACC 2004, 44:720-732.
3. Anderson J.W., Baird P., Davis R.H., et al. Health benefits of dietary fiber. Nutr Rev 2009, 67:188-205.
4. Sierra M., García J.J., Fernández N., Diez M.J., Calle A.P. Farmafibra group. Therapeutic effects of psyllium in type 2 diabetic patients. Eur J Clin Nutr 2002, 56:830-842.
5. Brown L., Rosner B., Willett W.W., Sacks F.M. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 1999, 69:30-42.
6. Solà R., Godàs G., Ribalta J., et al. Effects of soluble fiber (Plantago ovata husk) on plasma lipids, lipoproteins, and apolipoproteins in men with ischemic heart disease. Am J Clin Nutr 2007, 85:1157-1163.
7. Galisteo M., Morón R., Rivera L., et al. Plantago ovata husks-supplemented diet ameliorates metabolic alterations in obese Zucker rats through activation of AMP-activated protein kinase. Comparative study with other dietary fibers. Clin Nutr 2009, (September). [Epub ahead of print].
8. Anderson J.W., Randles K.M., Kendall C.W.C., Jenkins D.J.A. Carbohydrate and fiber recommendations for individuals with diabetes: a quantitative assessment and meta-analysis of the evidence. J Am Coll Nutr 2004, 23:5-17.
9. Salas-Salvadó J., Farrés X., Luque X., et al. Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial. Br J Nutr 2008, 99:1380-1387.
10. Ordovas J.M., Tai E.S. Why study gene-environment interactions?. Curr Opin Lipidol 2008, 19:158-167.
11. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
12. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
13. Brunzell J.D., Hypertriglyceridemia N Engl J Med 2007, 357(10):1009-1017.
14. Meisinger C., Baumert J., Khuseyinova N., Loewel H., Koenig W. Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events on apparently healthy, middle-aged men from the general population. Circulation 2005, 112:651-657.
15. Fitó M., Guxens M., Corella D., et al. Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial. Arch Intern Med 2007, 167:1195-1203.
16. Whelton S.P., Hyre A.D., Pedersen B., et al. Effect of dietary fiber intake on blood pressure: a meta-analysis of randomized, controlled clinical trials. J Hypertens 2005, 23:475-481.
17. Landmesser U., Drexler H. Endothelial function and hypertension. Curr Opin Cardiol 2007, 22:316-320.
18. Guxens M., Fitó M., Martínez-González M.A., et al. Hypertensive status and lipoprotein oxidation in an elderly population at high cardiovascular risk. Am J Hypertens 2009, 22:68-73.
19. Ceriello A. Possible role of oxidative stress in the pathogenesis of hypertension. Diabetes Care 2008, 31(Suppl. 2):S181-S184.
20. Morgan T.O., Anderson A.I., MacInnis R.J. ACE inhibitors, beta-blockers, calcium blockers, and diuretics for the control of systolic hypertension. Am J Hypertens 2001, 14:241-247.
21. Tuan C.-Y., Abbasi F., Lamendola C., McLaughlin T., Reaven G. Usefulness of plasma glucose and insulin concentrations in identifying patients with insulin resistance. Am J Cardiol 2003, 92:606-610.
22. Holvoet P., Lee D.H., Steffes M., Gross M., Jacobs D.R. Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. JAMA 2008, 299:2287-2293.
23. Moreyra A.E., Wilson A.C., Koraym A. Effect of combining psyllium fiber with simvastatin in lowering cholesterol. Arch Intern Med 2005, 165:1161-1166.