Folate-targeted supramolecular vesicular aggregates based on polyaspartyl-hydrazide copolymers for the selective delivery of antitumoral drugs

Biomaterials

Volumn 31, Issue 28, 2010, Pages 7340-7354

  Licciardi, Mariano ^a   Paolino, Donatella ^b   Celia, Christian ^b   Giammona, Gaetano ^a,c   Cavallaro, Gennara ^a   Fresta, Massimo ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c CNR   (Italy)

Author keywords

Biocompatibility; Controlled drug release; Cytotoxicity; Drug delivery; Liposome; Nanocomposite

Indexed keywords

ANTI-CANCER THERAPIES; ANTI-PROLIFERATIVE; ANTICANCER ACTIVITIES; ANTITUMORAL DRUGS; CANCER CELL LINES; CIRCULATORY SYSTEMS; CONTROLLED DRUG RELEASE; FLOW CYTOMETRY ANALYSIS; FOLATE RECEPTOR; GEMCITABINE; IN-CELL; IN-VITRO; IN-VIVO; MCF-7 CELLS; MEAN SIZE; PHYSICOCHEMICAL PROPERTY; PLASMA CONCENTRATION; POLYDISPERSITY INDICES; POLYMERIC MATERIAL; VESICULAR AGGREGATES;

BIOCOMPATIBILITY; BIOLOGICAL MATERIALS; CARDIOVASCULAR SYSTEM; CELL CULTURE; CONFOCAL MICROSCOPY; COPOLYMERIZATION; COPOLYMERS; DRUG PRODUCTS; FLOW CYTOMETRY; LIPOSOMES; NANOCOMPOSITES; PHOSPHOLIPIDS; POLYDISPERSITY; SUPRAMOLECULAR CHEMISTRY; ZETA POTENTIAL;

CONTROLLED DRUG DELIVERY;

ANTINEOPLASTIC AGENT; COPOLYMER; FOLATE RECEPTOR; FOLIC ACID; GEMCITABINE; LIPOSOME; POLYASPARTYL HYDRAZIDE; UNCLASSIFIED DRUG; AZIDE; BIOMATERIAL; DEOXYCYTIDINE; DRUG CARRIER; PEPTIDE; POLYASPARTIC ACID; POLYMER;

ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; FLOW CYTOMETRY; GENE OVEREXPRESSION; IN VITRO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SCINTILLATION; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; MATERIALS TESTING; METABOLISM; SYNTHESIS; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; AZIDES; BIOCOMPATIBLE MATERIALS; CELL LINE, TUMOR; DEOXYCYTIDINE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FOLIC ACID; HUMANS; MATERIALS TESTING; MICROSCOPY, CONFOCAL; MOLECULAR STRUCTURE; PEPTIDES; POLYMERS; TISSUE DISTRIBUTION;

EID: 77955279339     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.05.060     Document Type: Article

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