High frequency of immature cells at diagnosis predicts high minimal residual disease level in childhood acute lymphoblastic leukemia

Leukemia Research

Volumn 34, Issue 9, 2010, Pages 1139-1142

  Ebinger, Martin ^a   Witte, Kai Erik ^a   Ahlers, Jörg ^a   Schäfer, Iris ^a   André, Maya ^a   Kerst, Gunter ^a   Scheel Walter, Hans Gerhard ^a   Lang, Peter ^a   Handgretinger, Rupert ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Acute lymphoblastic leukemia; Immature leukemic cell fraction; Leukemic stem cell; Minimal residual disease; Prognostic factor

Indexed keywords

ASPARAGINASE; CD34 ANTIGEN; CD38 ANTIGEN; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; STEROID; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; INFANT; LEUKEMIA CELL; MALE; MINIMAL RESIDUAL DISEASE; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; SCHOOL CHILD; T LYMPHOCYTE;

EID: 77955273248     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.03.023     Document Type: Article

References (15)

1. Pui C.H., Robison L.L., Look A.T. Acute lymphoblastic leukaemia. Lancet 2008, 371:1030-1043.
2. Lapidot T., Sirard C., Vormoor J., Murdoch B., Hoang T., Caceres-Cortes J., et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994, 367:645-648.
3. Hope K.J., Jin L., Dick J.E. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol 2004, 5:738-743.
4. Wang J.C., Lapidot T., Cashman J.D., Doedens M., Addy L., Sutherland D.R., et al. High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase. Blood 1998, 91:2406-2414.
5. Dick J.E. Stem cell concepts renew cancer research. Blood 2008, 112:4793-4807.
6. Castor A., Nilsson L., strand-Grundstrom I., Buitenhuis M., Ramirez C., Anderson K., et al. Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. Nat Med 2005, 11:630-637.
7. Hong D., Gupta R., Ancliff P., Atzberger A., Brown J., Soneji S., et al. Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science 2008, 319:336-339.
8. le V.C., Hotfilder M., Bomken S., Wilson K., Rottgers S., Schrauder A., et al. In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell 2008, 14:47-58.
9. + cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia 2008, 22:1207-1213.
10. Misaghian N., Ligresti G., Steelman L.S., Bertrand F.E., Basecke J., Libra M., et al. Targeting the leukemic stem cell: the Holy Grail of leukemia therapy. Leukemia 2009, 23:25-42.
11. de Figueiredo-Pontes L.L., Pintao M.C., Oliveira L.C., Dalmazzo L.F., Jacomo R.H., Garcia A.B., et al. Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia. Cytometry B Clin Cytom 2008, 74:163-168.
12. van Dongen J.J., Seriu T., Panzer-Grumayer E.R., Biondi A., Pongers-Willemse M.J., Corral L., et al. Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood. Lancet 1998, 352:1731-1738.
13. Campana D. Status of minimal residual disease testing in childhood haematological malignancies. Br J Haematol 2008, 143:481-489.
14. Chung N.G., Buxhofer-Ausch V., Radich J.P. The detection and significance of minimal residual disease in acute and chronic leukemia. Tissue Antigens 2006, 68:371-385.
15. Flohr T., Schrauder A., Cazzaniga G., Panzer-Grumayer R., van dV V., Fischer S., et al. Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia. Leukemia 2008, 22:771-782.