The modern management of endometrial cancer

Oncology Reviews

Volumn 1, Issue 2, 2007, Pages 103-119

  Holland, Catherine M ^a   Kitchener, Henry C ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Controversies; Endometrial cancer; Evidence; Management

Indexed keywords

EID: 77955270302     PISSN: 19705557     EISSN: 19705565     Source Type: Journal    
DOI: 10.1007/s12156-007-0012-6     Document Type: Review

References (101)

1. Smith-Bindman R, Kerlikowske K, Feldstein VA et al (1998) Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. JAMA 280:1510-1517 (Pubitemid 28507404)
2. Kurman RJ, Kaminski PF, Norris HJ (1985) The behavior of endometrial hyperplasia - a long term study of untreated hyperplasia in 170 patients. Cancer 56:403-412 (Pubitemid 15031667)
3. Widra EA, Dunton CJ, McHugh M et al (1995) Endometrial hyperplasia and the risk of carcinoma. Int J Gynecol Cancer 5:233-235
4. Baak JP, Mutter GL, Robboy S et al (2005) The molecular genetics and morphometry-based Endometrial Intraepithelial Neoplasia classification system predicts disease progression in Endometrial hyperplasia more accurately than the 1994 World Health Organization classification system. Cancer 103:2304-2312 (Pubitemid 40686575)
5. Mutter GL, Zaino RJ, Baak JPA et al (2007) Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol 26:103-114 (Pubitemid 46573204)
6. Matias-Guiu X, Catasus L, Bussaglia E et al (2001) Molecular pathology of endometrial hyperplasia and carcinoma. Hum Pathol 32:569-577 (Pubitemid 32601237)
7. Ambros RA, Sherman ME, Zahn CM et al (1995) Endometrial intraepithelial carcinoma - a distinctive lesion specifically associated with tumours displaying serous differentiation ON. Hum Pathol 26:1260-1267
8. Sakuragi N, Hareyama H, Todo Y et al (2000) Prognostic significance of serous and clear cell adenocarcinoma in surgically staged endometrial carcinoma. Acta Obstet Gynecol Scand 79:311-316 (Pubitemid 30156504)
9. Sherman ME, Bitterman P, Rosenshein NB et al (1992) Uterine serous carcinoma - a morphologically diverse neoplasm with unifying clinicopathological features. Am J Surg Pathol 16:600-610
10. Wheeler DT, Bell KA, Kurman RJ et al (2000) Minimal uterine serous carcinoma - Diagnosis and clinicopathologic correlation. Am J Surg Pathol 24:797-806 (Pubitemid 30366266)
11. Morrow CP, Bundy BN, Kurman RJ et al (1991) Relationship between surgical Pathological risk-factors and outcome in clinical stage-I And Stage-II carcinoma of the endometrium - A Gynecologic Oncology Group-Study. Gynecol Oncol 40:55-65
12. Lu KH, Broaddus RR (2005) Gynecologic cancers in Lynch syndrome/ HNPCC. Fam Cancer 4:249-254 (Pubitemid 41242195)
13. Kinkel K, Kaji Y, Yu KK et al (1999) Radiologic staging in patients with endometrial cancer: A meta-analysis. Radiology 212:711-718 (Pubitemid 29410973)
14. Cunha TM, Felix A, Cabral I (2001) Preoperative assessment of deep myometrial and cervical invasion in endometrial carcinoma: Comparison of magnetic resonance imaging and gross visual inspection. Intern J Gynecol Cancer 11:130-136 (Pubitemid 32381661)
15. Sironi S, Picchio M, Landoni C et al (2007) Post-therapy surveillance of patients with uterine cancers: value of integrated FDG PET/CT in the detection of recurrence. Eur J Nucl Med Mol Imaging 34:472-479 (Pubitemid 46426981)
16. Creasman WT, Morrow CP, Bundy BN et al (1987) Surgical pathological spread patterns of endometrial cancer -A Gynecologic Oncology Group-Study. Cancer 60:2035-2041 (Pubitemid 17145924)
17. International Federation of Gynaecology and Obstetrics (1989) Corpus cancer staging. Intern J Gynecol Obste 28:189-190
18. Sood BM, Jones J, Gupta S et al (2003) Patterns of failure after the multimodality treatment of uterine papillary serous carcinoma. Int J Radiat Oncol Biol Phys 57:208-216 (Pubitemid 36959758)
19. Geisler JP, Geisler KE, Melton ME et al (1999) What staging surgery should be performed on patients with uterine papillary serous carcinoma? Gynecol Oncol 74:465-467 (Pubitemid 29439891)
20. Gehrig PA, Van Le L, Fowler WC (2003) The role of omentectomy during the surgical staging of uterine serous carcinoma. Int J Gynecol Cancer 13:212-215 (Pubitemid 37055480)
21. Maggino T, Romagnolo C, Landoni F et al (1998) An analysis of approaches to the management of endometrial cancer in North America: A CTF study. Gynecol Oncol 68:274-279 (Pubitemid 28183499)
22. Maggino T, Romagnolo C, Zola P et al (1995) An analysis of approaches to the treatment of endometrial cancer in Western Europe: A CTF study. Eur J Cancer 31A:1993-1997 (Pubitemid 26023089)
23. Chan JK, Cheung MK, Huh WK et al (2006) Therapeutic role of lymph node resection in endometrioid corpus cancer - A study of 12,333 patients. Cancer 107:1823-1830 (Pubitemid 44582951)
24. Kilgore LC, Partridge EE, Alvarez RD et al (1995) Adenocarcinoma of the endometrium - survival comparisons of patients with and without pelvic node sampling. Gynecol Oncol 56:29-33
25. Mohan DS, Samuels MA, Selim MA et al (1998) Long-term outcomes of therapeutic pelvic lymphadenectomy for stage I endometrial adenocarcinoma. Gynecol Oncol 70:165-171 (Pubitemid 28430923)
26. Endometrial cancer Study Group COZA-NZ-UK G (1996) Pelvic lymphadenectomy in high risk endometrial cancer. Intern J Gynecol Cancer 6:102-107
27. Kitchener HC RC, Swart AMC, Amos CL (2005) ASTEC (surgery component): a study in the treatment of endometrial cancer. A randomized trial of lymphadenectomy in the treatment of endometrial cancer. ESGO 2005. Int J Gynecol Cancer 15[Suppl 2]:77 [Abstract 00094].
28. Boothby RA, Carlson JA, Neiman Wet al (1989) Treatment of stage-II endometrial carcinoma. Gynecol Oncol 33:204-208
29. Cornelison TL, Trimble EL, Kosary CL (1999) SEER data, corpus uteri cancer: Treatment trends versus survival for FIGO stage II, 1988-1994 Gynecol Oncol 74:350-355 (Pubitemid 29439872)
30. Mannel RS, Berman ML, Walker JL et al (1990) Management of endometrial cancer with suspected cervical involvement. Obstet Gynecol 75:1016-1022 (Pubitemid 20176776)
31. Eltabbakh GH, Shamonki MI, Moody JM et al (2000) Hysterectomy for obese women with endometrial cancer: Laparoscopy or laparotomy? Gynecol Oncol 78:329-335
32. Fram KM (2002) Laparoscopically assisted vaginal hysterectomy versus abdominal hysterectomy in stage I endometrial cancer. Int J Gynecol Cancer 12:57-61 (Pubitemid 34202950)
33. Gemignani ML, Curtin JP, Zelmanovich J et al (1999) Laparoscopic-assisted vaginal hysterectomy for endometrial cancer: Clinical outcomes and hospital charges. Gynecol Oncol 73:5-11 (Pubitemid 29177591)
34. Holub Z, Bartos P, Eim J (1999) Laparoscopic surgery of endometrial cancer. Preliminary results of a multicentric study. Gynaecol Endoscopy 8:271-276
35. Obermair A, Manolitsas TP, Leung Y et al (2005) Total laparoscopic hysterectomy versus total abdominal hysterectomy for obese women with endometrial cancer. Int J Gynecol Cancer 15:319-324 (Pubitemid 40396972)
36. O'Hanlan KA, Dibble SL, Fisher DT (2006) Total laparoscopic hysterectomy for uterine pathology: Impact of body mass index on outcomes. Gynecol Oncol 103:938-941 (Pubitemid 44821318)
37. Yu CK, Cutner A, Mould T et al (2005) Total laparoscopic hysterectomy as a primary surgical treatment for endometrial cancer in morbidly obese women. BJOG 112:115-117 (Pubitemid 40095093)
38. Lim BK, Lavie O, Bolger B et al (2000) The role of laparoscopic surgery in the management of endometrial cancer. BJOG 107:24-27 (Pubitemid 30042721)
39. Malur S, Possover M, Michels Wet al (2001) Laparoscopic-assisted vaginal versus abdominal surgery in patients with endometrial cancer - A prospective randomized trial. Gynecol Oncol 80:239-244 (Pubitemid 32158465)
40. Possover M, Krause N, Plaul K et al (1998) Laparoscopic para-aortic and pelvic lymphadenectomy: Experience with 150 patients and review of the literature. Gynecol Oncol 71:19-28 (Pubitemid 28492388)
41. Kohler C, Klemm P, Schau A et al (2004) Introduction of transperitoneal lymphadenectomy in a gynecologic oncology center: analysis of 650 laparoscopic pelvic and/or paraaortic transperitoneal lymphadenectornies. Gynecol Oncol 95:52-61 (Pubitemid 39286277)
42. Holub Z, Jabor A, Bartos P et al (2003) Laparoscopic surgery in women with endometrial cancer: the learning curve. Eur J Obstetr Gynecol Reprod Biol 107:195-200 (Pubitemid 36332060)
43. Eltabbakh GH, Shamonki MI, Moody JM et al (2001) Laparoscopy as the primary modality for the treatment of women with endometrial carcinoma. Cancer 91:378-387 (Pubitemid 32099240)
44. Holub Z, Jabor A, Bartos P et al (2002) Laparoscopic surgery for endometrial cancer: long-term results of a multicentric study. Eur J Gynaecol Oncol 23:305-310 (Pubitemid 34948045)
45. Sonoda Y, Zerbe M, Smith A et al (2001) High incidence of positive peritoneal cytology in low-risk endometrial cancer treated by laparoscopically assisted vaginal hysterectomy. Gynecol Oncol 80:378-382 (Pubitemid 32207539)
46. Lelle RJ, Morley GW, Peters WA (1994) The role of vaginal hysterectomy in the treatment of endometrial carcinoma CINOMA. Int J Gynecol Cancer 4:342-347
47. Chan KJ, Lin YG, Monk BJ et al (2001) Vaginal hysterectomy as primary treatment of endometrial cancer in medically compromised women. Obstet Gynecol 97:707-711
48. Creutzberg CL, van Putten WLJ, Koper PC et al (2001) The morbidity of treatment for patients with stage I endometrial cancer: Results from a randomized trial. Intern J Radiation Oncol Biol Physics 51:1246-1255 (Pubitemid 33116318)
49. Creutzberg CL, van Putten WLJ, Koper PCM et al (2000) Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. Lancet 355:1404-1411 (Pubitemid 30215963)
50. Kong A, Simera I, Collingwood M et al (2007) On behalf of Cochrane Gynaecological Cancer Group. Adjuvant radiotherapy for stage I endometrial cancer: systematic review and meta-analysis. Ann Oncol. #March 19([Epub ahead of print]).
51. Orton J, Blake P, on behalf of ASTEC/EN.5 collaborators. Adjuvant external beam radiotherapy (EBRT) in the treatment of endometrial cancer: Results of the randomised MRC ASTEC and NCIC CTG EN.5 trial. ASCO Meeting Abstracts 25 [Suppl 185]:5504
52. Jolly S, Vargas C, Kumar T et al (2005) Vaginal brachytherapy alone: An alternative to adjuvant whole pelvis radiation for early stage endometrial cancer. Gynecol Oncol 97:887-892 (Pubitemid 40824661)
53. Horowitz NS, Peters WA, Smith MR et al (2002) Adjuvant high dose rate vaginal brachytherapy as treatment of stage I and II endometrial carcinoma. Obstet Gynecol 99:235-240 (Pubitemid 34113995)
54. Solhjem MC, Petersen IA, Haddock MG (2005) Vaginal brachytherapy alone is sufficient adjuvant treatment of surgical stage I endometrial cancer. Int J Radiat Oncol Biol Phys 62:1379-1384 (Pubitemid 40982058)
55. Lin LL, Mutch DG, Rader JS et al (2007) External radiotherapy versus vaginal; brachytherapy for patients with intermediate risk endometrial cancer. Gynecol Oncol; doi:10.1016/j.ygyno.2007.03.024 (Pubitemid 46898597)
56. Creutzberg CL, van Putten WLJ, Warlam-Rodenhuis CC et al (2004) Outcome of high-risk stage IC, grade 3, compared with stage I endometrial carcinoma patients: The postoperative radiation therapy in endometrial carcinoma trial. J Clin Oncol 22:1234-1241 (Pubitemid 41079837)
57. Keys HM, Roberts JA, Brunetto VL et al (2004) A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 92:744-751 (Pubitemid 38251372)
58. Mundt AJ, McBride R, Rotmensch J et al (2001) Significant pelvic recurrence in high-risk pathologic stage I-IV endometrial carcinoma patients after adjuvant chemotherapy alone: Implications for adjuvant radiation therapy. Int J Radiat Oncol Biol Phys 50:1145-1153 (Pubitemid 32727790)
59. Kodama J, Seki N, Hiramatsu Y (2007) Chemotherapy for high-risk early-stage endometrial cancer. Curr Opin Obstet Gynecol 19:42-47 (Pubitemid 46095872)
60. Kodama J, Seki N, Ojima Y et al (2007) Efficacy and prognostic implications of administering adjuvant chemotherapy to patients with endometrial cancer that is confined to the uterus. Eur J Obstet Gynecol Reprod Biol 131:76-80 (Pubitemid 46283185)
61. Hirai M, Hirono M, Oosaki T et al (2002) Adjuvant chemotherapy in stage I uterine endometrial carcinoma. Int J Gynaecol Obstet 78:37-44 (Pubitemid 34756768)
62. Aoki Y, Watanabe M, Amikura T et al (2004) Adjuvant chemotherapy as treatment of high-risk stage I and II endometrial. Gynecol Oncol 94:333-339 (Pubitemid 39024535)
63. Maggi R, Lissoni A, Spina F et al (2006) Adjuvant chemotherapy vs radiotherapy in high-risk endometrial carcinoma: results of a randomised trial. Br J Cancer 95:266-271 (Pubitemid 44187586)
64. Sagae S, Udagawa Y, Susumu N et al (2005) JGOG2033: Randomized phase III trial of whole pelvic radiotherapy vs. cisplatin-based chemotherapy in patients with intermediate risk endometrial carcinoma. J Clin Oncol 23[Suppl 16]:5002
65. Morrow CP, Bundy BN, Homesley HD et al (1990) Doxorubicin as an adjuvant following surgery and radiation-therapy in patients with high-risk endometrial carcinoma, stage-I and occult stage-II -a Gynecologic Oncology Group-Study. Gynecol Oncol 36:166-171 (Pubitemid 20061279)
66. Hogberg T, Rosenberg P, Kristensen G et al (2007) A randomized phase-III study on adjuvant treatment with radiation (RT) +/- chemotherapy (CT) in early-stage high-risk endometrial cancer (NSGO-EC-9501/EORTC 55991). J Clin Oncol 25:5503
67. Sutton G, Axelrod JH, Bundy BN et al (2006) Adjuvant whole abdominal irradiation in clinical stages I and II papillary serous or clear cell carcinoma of the endometrium: A phase II study of the Gynecologic Oncology Group. Gynecol Oncol 100:349-354 (Pubitemid 43075268)
68. Kelly MG, O'Malley DM, Hui P et al (2005) Improved survival in surgical stage I patients with uterine papillary serous carcinoma (UPSC) treated with adjuvant platinum-based chemotherapy. Gynecol Oncol 98:353-359 (Pubitemid 41169144)
69. Martin-Hirsch PL, Jarvis G, Kitchener H et al Progestagens for endometrial cancer. Cochrane Database Syst Rev 2000(2):CD001040.
70. Lee RB, Burke TW, Park RC (1990) Estrogen replacement therapy following treatment for stage 1 endometrial carcinoma. Gynecol Oncol 36:189-191 (Pubitemid 20061284)
71. Chapman JA, DiSaia PJ, Osann K et al (1996) Estrogen replacement in surgical stage I and II endometrial cancer survivors. Am J Obstet Gynecol 175:1195-1200 (Pubitemid 26398977)
72. Creasman WT, Henderson D, Hinshaw Wet al (1986) Estrogen replacement therapy in the patient treated for endometrial cancer. Obstet Gynecol 67:326-330 (Pubitemid 16129969)
73. Fishman DA, Roberts KB, Chambers JT et al (1996) Radiation therapy as exclusive treatment for medically inoperable patients with stage I and II endometrioid carcinoma of the endometrium. Gynecologic Oncology 61:189-196 (Pubitemid 26145722)
74. Nguyen TV, Petereit DG (1998) Highdose-rate brachytherapy for medically inoperable stage I endometrial cancer. Gynecol Oncol 71:196-203 (Pubitemid 28550801)
75. Lehoczky O, Bosze P, Ungar L et al (1991) Stage 1 endometrial carcinoma -treatment of non-operable patients with intracavitary radiation therapy alone. Gynecol Oncol 43:211-216
76. Rouanet P, Dubois JB, Gely S et al (1993) Exclusive radiation therapy in endometrial carcinoma. Int J Radiat Oncol Biol Phys 26:223-228 (Pubitemid 23156968)
77. Kucera H, Knocke TH, Kucera E et al (1998) Treatment of endometrial carcinoma with high-dose-rate brachytherapy alone in medically inoperable stage I patients. Acta Obstet Gynecol Scand 77:1008-1012 (Pubitemid 29043928)
78. Bokhman JV, Chepick OF, Volkova AT et al (1985) Can primary endometrial carcinoma stage 1 be cured without surgery and radiation therapy. Gynecol Oncol 20:139-155 (Pubitemid 15133008)
79. Farthing A (2006) Conserving fertility in the management of gynaecological cancers. BJOG: An International Journal of Obstetrics and Gynaecology 113:129-134
80. Chi DS, Welshinger M, Venkatraman ES et al (1997) The role of surgical cytoreduction in Stage IV endometrial carcinoma. Gynecol Oncol 67:56-60 (Pubitemid 27433329)
81. Goff BA, Goodman A, Muntz HG et al (1994) Surgical stage IV endometrial carcinoma - a study of 47 cases. Gynecol Oncol 52:237-240 (Pubitemid 24064377)
82. Memarzadeh S, Holschneider CH, Bristow RE et al (2002) FIGO stage III and IV uterine papillary serous carcinoma: Impact of residual disease on survival. Intern J Gynecol Cancer 12:454-458
83. Aapro MS, van Wijk FH, Bolis G et al (2003) Doxorubicin versus doxorubicin and cisplatin in endometrial carcinoma: definitive results of a randomised study (55872) by the EORTC Gynaecological Cancer Group. Ann Oncol 14:441-448 (Pubitemid 36367423)
84. Woo HL, Swenerton KD, Hoskins PJ (1996) Taxol is active in platinum-resistant endometrial adenocarcinoma. Am J Clin Oncol-Cancer Clin Trials 19:290-291 (Pubitemid 26160559)
85. Lissoni A, Zanetta G, Losa G et al (1996) Phase II study of paclitaxel as salvage treatment in advanced endometrial cancer. Ann Oncol 7:861-863 (Pubitemid 26345880)
86. Lincoln S, Blessing JA, Lee RB et al (2003) #Activity of paclitaxel as second-line chemotherapy in endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 88:277-281 (Pubitemid 36335809)
87. Zanotti KM, Belinson JL, Kennedy AW et al (1999) The use of paclitaxel and platinum-based chemotherapy in uterine papillary serous carcinoma. Gynecol Oncol 74:272-277 (Pubitemid 29377225)
88. Wylie J, Irwin C, Pintilie M et al (2000) Results of radical radiotherapy for recurrent endometrial cancer. Gynecol Oncol 77:66-72 (Pubitemid 30217306)
89. Sears JD, Greven KM, Hoen HM et al (1994) Prognostic factors and treatment outcome for patients with locally recurrent endometrial cancer. Cancer 74:1303-1308 (Pubitemid 24301784)
90. Hoekstra CJM, Koper PCM, Vanputten WLJ (1993) Recurrent endometrial adenocarcinoma after surgery alone - prognostic factors and treatment. Radiother Oncol 7:164-166
91. Creutzberg CL, van Putten WLJ, Koper PC et al (2003) Survival after relapse in patients with endometrial cancer: results from a randomized trial. Gynecol Oncol 89:201-209 (Pubitemid 36457866)
92. Campagnutta E, Giorda G, De Piero G et al (2004) Surgical treatment of recurrent endometrial carcinoma. Cancer 100:89-96 (Pubitemid 37553543)
93. Morris M, Alvarez RD, Kinney WK et al (1996) Treatment of recurrent adenocarcinoma of the endometrium with pelvic exenteration. Gynecol Oncol 60:288-291 (Pubitemid 26058775)
94. Barakat RR, Goldman NA, Patel DA et al (1999) Pelvic exenteration for recurrent endometrial cancer. Gynecol Oncol 75:99-102 (Pubitemid 29477809)
95. Thigpen JT, Brady MF, Alvarez RD et al (1999) Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: A dose-response study by the Gynecologic Oncology Group. J Clin Oncol 17:1736-1744 (Pubitemid 29269242)
96. Whitney CW, Brunetto VL, Zaino RJ et al (2004) Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 92:4-9 (Pubitemid 38147364)
97. Humber CE, Tierney JF, Symonds RP et al (2007) Chemotherapy for advanced, recurrent or metastatic endometrial cancer: a systematic review of Cochrane collaboration. Ann Oncol 18:409-420 (Pubitemid 46359618)
98. Agboola OO, Grunfeld E, Coyle Det al (1997) Costs and benefits of routine follow-up after curative treatment for endometrial cancer. CMAJ 157:879-886 (Pubitemid 27460103)
99. Berchuck A, Anspach C, Evans AC et al (1995) Postsurgical surveillance of patients with FIGO stage I/II endometrial adenocarcinoma CARCINOMA. Gynecol Oncol 59:20-24
100. Morice P, Levy-Piedbois C, Ajaj S et al (2001) Value and cost evaluation of routine follow-up for patients with clinical stage I/II endometrial cancer. Eur J Cancer 37:985-990 (Pubitemid 32397683)
101. Shumsky AG, Stuart GCE, Brasher PM et al (1994) An evaluation of routine follow-up of patients treated for endometrial carcinoma. Gynecol Oncol 55:229-233