Artesunate-clindamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products

Journal of Controlled Release

Volumn 146, Issue 1, 2010, Pages 54-60

  Strusi, Orazio Luca ^a   Barata, Pedro ^b   Traini, Daniela ^c   Young, Paul M ^c   Mercuri, Salvatore ^a   Colombo, Gaia ^d   Sonvico, Fabio ^a   Bettini, Ruggero ^a   Colombo, Paolo ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF FERRARA   (Italy)

Author keywords

Artesunate; Clindamycin; Floating dosage form; Malaria combination therapy; Release module assemblage

Indexed keywords

ARTESUNATE; CLINDAMYCIN; COMBINATION THERAPY; DOSAGE FORMS; RELEASE MODULE;

BIOCHEMISTRY; DRUG DELIVERY;

DRUG PRODUCTS;

ANTIMALARIAL AGENT; ARTESUNATE; CALCIUM PHOSPHATE DIBASIC; CARBOXYMETHYLSTARCH SODIUM; CLINDAMYCIN PHOSPHATE; DODECYL SULFATE SODIUM; HYDROXYPROPYLMETHYLCELLULOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; POVIDONE; STARCH; TALC;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED RELEASE FORMULATION; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; FEMALE; KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; TABLET; TECHNOLOGY;

ADMINISTRATION, ORAL; ANIMALS; ANTIMALARIALS; ARTEMISININS; BIOLOGICAL AVAILABILITY; CLINDAMYCIN; DELAYED-ACTION PREPARATIONS; DOGS; DRUG COMBINATIONS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; SOLUBILITY; STOMACH;

EID: 77955269646     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.05.001     Document Type: Article

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