Therapeutic approaches to pregnancy loss of non-infectious cause during the late embryonic/early foetal period in dairy cattle. A review

Reproduction in Domestic Animals

Volumn 45, Issue 6, 2010, Pages

  Bech Sabat G ^a   Garcia Ispierto I ^a   Yaniz J ^b   Lopez Gatius F ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

^b UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CATTLE; CATTLE DISEASE; DAIRYING; FEMALE; GESTATIONAL AGE; PREGNANCY; REVIEW; VETERINARY ABORTION;

ABORTION, VETERINARY; ANIMALS; CATTLE; CATTLE DISEASES; DAIRYING; FEMALE; GESTATIONAL AGE; PREGNANCY;

BOS;

EID: 77955260218     PISSN: 09366768     EISSN: 14390531     Source Type: Journal    
DOI: 10.1111/j.1439-0531.2009.01562.x     Document Type: Review

References (105)

1. 4) intravaginal device (CIDR) to reduce embryonic loss and to synchronize return to oestrus of previously timed inseminated lactating dairy cows. Anim Reprod Sci 107, 36-47.
2. Arck P, Hansen PJ, Jericevic BM, Piccinni MP, Szekeres-Bartho J, 2007: Progesterone during pregnancy: endocrine-immune crosstalk in mammalian species and the role of stress. Am J Reprod Immunol 58, 268-279.
3. Ayad A, Sousa NM, Sulon J, Hornick JL, Watts J, López-Gatius F, Iguer-Ouada M, Beckers JF, 2007: Influence of progesterone concentrations on secretory functions of trophoblast and pituitary during the first trimester of pregnancy in dairy cattle. Theriogenology 67, 1503-1511.
4. Ball PJH, 1997: Later embryo and early fetal mortality in the cow. Anim Breed Abs 65, 167-175.
5. Bartolomé JA, Silvestre FT, Kamimura S, Arteche ACM, Melendez P, Kelbert D, McHale J, Swift K, Archbald LF, Thatcher WW, 2005a: Resynchronization of ovulation and timed insemination in lactating dairy cows I: use of the Ovsynch and Heatsynch protocols after non-pregnancy diagnosis by ultrasonography. Theriogenology 63, 1617-1627.
6. Bartolomé JA, Sozzi A, McHale J, Melendez P, Arteche ACM, Silvestre FT, Kelbert D, Swift K, Archbald LF, Thatcher WW, 2005b: Resynchronization of ovulation and timed insemination in lactating dairy cows, II: assigning protocols according to stages of the estrous cycle, or presence of ovarian cysts or anestrus. Theriogenology 63, 1628-1642.
7. Bartolomé JA, Sozzi A, McHale J, Swift K, Kelbert D, Archbald LF, Thatcher WW, 2005c: Resynchronization of ovulation and timed insemination in lactating dairy cows III. Administration of GnRH 23 days post AI and ultrasonography for nonpregnancy diagnosis on day 30. Theriogenology 63, 1643-1658.
8. Bartolomé JA, Melendez P, Kelbert D, Swift K, McHale J, Hernandez J, Silvestre F, Risco CA, Arteche ACM, Thatcher WW, Archbald LF, 2005d: Strategic use of gonadotrophin-releasing hormone (GnRH) to increase pregnancy rate and reduce pregnancy loss in lactating dairy cows subjected to synchronization of ovulation and timed insemination. Theriogenology 63, 1026-1037.
9. Bartolomé JA, Kamimura S, Silvestre F, Arteche ACM, Trigg T, Thatcher WW, 2006: The use of a deslorelin implant (GnRH agonist) during the late embryonic period to reduce pregnancy loss. Theriogenology 65, 1443-1453.
10. Bazer FW, 1975: Uterine protein secretions: relationship to development of the conceptus. J Anim Sci 41, 1376-1382.
11. Bech-Sàbat G, García-Ispierto I, Yániz JL, López-Gatius F, 2007: High milk production increases the risk of early fetal loss in dairy cows. Reprod Domest Anim 42(S2), 122.
12. Bech-Sàbat G, López-Gatius F, Yániz JL, García-Ispierto I, Santolaria P, Serrano B, Sulon J, De Sousa NM, Beckers JF, 2008: Factors affecting plasma progesterone in the early fetal period in high producing dairy cows. Theriogenology 69, 426-432.
13. Bech-Sàbat G, López-Gatius F, García-Ispierto I, Santolaria P, Serrano B, Nogareda C, De Sousa NM, Beckers JF, Yániz J, 2009: Pregnancy patterns during the early fetal period in high producing dairy cows treated with GnRH or progesterone. Theriogenology 71, 920-929.
14. Bishop CV, Stormshak F, 2008: Non-genomic actions of progesterone and estrogens in regulating reproductive events in domestic animals. Vet. J. 176, 270-280.
15. Bridges PJ, Wright DJ, Buford WI, Ahmad N, Hernandez-Fonseca H, McCormick ML, Schrick FN, Dailey RA, Lewis PE, Inskeep EK, 2000: Ability of induced corpora lutea to maintain pregnancy in beef cows. J Anim Sci 78, 2942-2949.
16. Cartmill JA, El-Zarkouny SZ, Hensley BA, Lamb GC, Stevenson JS, 2001a: Stage of cycle, incidence and timing of ovulation, and pregnancy rates in dairy cattle after three timed breeding protocols. J Dairy Sci 80, 3386-3398.
17. Cartmill JA, El-Zarkouny SZ, Hensley BA, Rozell TG, Smith JF, Stevenson JS, 2001b: An alternative AI breeding protocol for dairy cows exposed to elevated ambient temperatures before of after calving or both. J Dairy Sci 84, 799-806.
18. Cerri RLA, Rutigliano HM, Bruno RGS, Santos JEP, 2009: Progesterone concentration, follicular development and induction of cyclicity in dairy cows receiving intravaginal progesterone inserts. Anim Reprod Sci 110, 56-70.
19. Chebel RC, Santos JEP, Cerri RLA, Galvao KN, Juchem SO, Thatcher WW, 2003: Effect of resynchronization with GnRH on day 21 after artificial insemination on pregnancy rate and pregnancy loss in lactating dairy cows. Theriogenology 60, 1389-1399.
20. Chebel RC, Santos JEP, Reynolds JP, Cerri RLA, Juchem SO, Overton M, 2004: Factors affecting conception rate after artificial insemination and pregnancy loss in lactating dairy cows. Anim. Reprod. Sci 84, 239-255.
21. Chebel RC, Santos JEP, Cerri RLA, Rutigliano HM, Bruno RGS, 2006: Reproduction in dairy cows following progesterone insert presynchronization and resynchronization protocols. J Dairy Sci 89, 4205-4219.
22. Chenault JR, Kratzer DD, Rzepkowski RA, Goodwin MC, 1990: LH and FSH response of Holstein heifers to fertirelin acetate, gonadorelin and buserelin. Theriogenology 34, 81-98.
23. Committee on Bovine Reproductive Nomenclature, 1972: Recommendations for standardizing bovine reproductive terms. Cornell Vet. 62, 216-237.
24. Curran S, Pierson RA, Ginther OJ, 1986: Ultrasonographic appearance of the bovine conceptus from days 20 through 60. JAVMA 189, 1295-1302.
25. Dijkhuizen TJ, Van Eerdenburg FJCM, 1997: Behavioural signs of oestrus during pregnancy in lactating dairy cows. Vet. Quart. 119, 194-196.
26. Druckmann R, Druckmann MA, 2005: Progesterone and the immunology of pregnancy. J Steroid Biochem Mol Biol 97, 389-396.
27. Edwards DP, 2005: Regulation of signal transduction pathways by estrogen and progesterone. Annu Rev Physiol 67, 335-376.
28. El-Zarkouny SZ, Stevenson JS, 2004: Resynchronizing estrus with progesterone or progesterone plus estrogen in cows of unknown pregnancy status. J Dairy Sci 87, 3306-3321.
29. El-Zarkouny SZ, Cartmill JA, Hensley BA, Stevenson JS, 2004: Pregnancy in dairy cows after synchronized ovulation regimens with or without presynchronization and progesterone. J Dairy Sci 87, 1024-1037.
30. Falkenstein E, Tillmann HC, Christ M, Feuring M, Wehling M, 2000: Multiple actions of steroid hormones - a focus on rapid, nongenomic effects. Pharmacol Rev 52, 513-555.
31. Fischer-Tenhagen C, Thiele G, Heuwieser W, Tenhagen BA, 2008: Efficacy of a treatment with hCG 4 days after AI to reduce pregnancy losses in lactating dairy cows after synchronized ovulation. Reprod Domest Anim. doi:
32. Forar AL, Gay JM, Hancock DD, 1995: The frequency of endemic fetal loss in dairy cattle: a review. Theriogenology 43, 989-1000.
33. Fricke PM, Wiltbank MC, 1999: Effect of milk production on the incidence of double ovulation in dairy cows. Theriogenology 52, 1133-1143.
34. Gábor G, Tóth F, Ózsvári L, Abonyi-Tóth Zs, Sasser RG, 2008: Factors influencing pregnancy rate and late embryonic loss in dairy cattle. Reprod Domest Anim 43, 53-58.
35. Galvao KN, Santos JEP, Juchem SO, Cerri RLA, Coscioni AC, Villasen M, 2004: Effect of addition of a progesterone intravaginal insert to a timed insemination protocol using estradiol cypionate on ovulation rate, pregnancy rate, and late embryonic loss in lactating dairy cows. J Anim Sci 82, 3508-3517.
36. García-Ispierto I, López-Gatius F, Santolaria P, Yániz JL, Nogareda C, López-Béjar M, De Rensis F, 2006: Relationship between heat stress during the peri-implantation period and early fetal loss in dairy cattle. Theriogenology 65, 799-807.
37. Garrett JE, Geisert RD, Zavy MT, Morgan GL, 1988: Evidence for maternal regulation of early conceptus growth and development in beef cattle. J Reprod Fertil 84, 437-446.
38. Geisert RD, Zavy MT, Biggers BG, Garrett JE, Wetterman RP, 1992: Characterization of the uterine environment during early conceptus expansion in the bovine. Anim Reprod Sci 16, 11-25.
39. Gellersen B, Fernandes MS, Brosens JJ, 2009: Non-genomic progesterone actions in female reproduction. Hum Reprod Update 15, 119-138.
40. Gootwine E, 2004: Placental hormones and fetal-placental development. Anim Reprod Sci 82-83, 551-566.
41. Grimard B, Freret S, Chevallier A, Pinto A, Ponsart C, Humblot P, 2006: Genetic and environmental factors influencing first service conception rate and late embryonic/foetal mortality in low fertility dairy herds. Anim Reprod Sci 91, 31-44.
42. Hansen PJ, 1998: Regulation of uterine immune function by progesterone - lessons from the sheep. J Reprod Immunol 40, 63-79.
43. Hanzen CH, Drion PV, Loutrie O, Depierreux C, Christians E, 1999: Embryonic mortality. Part 1. Clinical aspects and etiological factors in the bovine species. Ann Med Vet 143, 91-118.
44. Inskeep EK, 2004: Preovulatory, postovulatory, and postmaternal recognition effects of concentrations of progesterone on embryonic survival in the cow. J Anim Sci 82, E24-E39.
45. Inskeep EK, Dailey RA, 2005: Embryonic death in cattle. Vet Clin Food Anim 21, 437-461.
46. Johanson JM, Berger PJ, Kirkpatrick BW, Dentines MR, 2001: Twinning rates for North American Holstein sires. J Dairy Sci 84, 2081-2088.
47. Jousan FD, Drost M, Hansen PJ, 2005: Factors associated with early and mid-to-late fetal loss in lactating and non-lactating Holstein cattle in a hot climate. J Anim Sci 83, 1017-1022.
48. Kinsel ML, Marsh WE, Ruegg PL, Etherington WG, 1998: Risk factors for twinning in dairy cows. J Dairy Sci 81, 989-993.
49. Labèrnia J, López-Gatius F, Santolaria P, López-Béjar M, Rutllant J, 1996: Influence of management factors on pregnancy attrition in dairy cattle. Theriogenology 45, 1247-1253.
50. Lemley CO, Butler ST, Butler WR, Wilson ME, 2008: Insulin alters hepatic progesterone catabolic enzymes cytochrome P450 2C and 3A in dairy cows. J Dairy Sci 91, 641-645.
51. López-Gatius F, 2000: Site of semen deposition in cattle: a review. Theriogenology 53, 1407-1414.
52. López-Gatius F, 2005: The effect on pregnancy rate of progesterone administration after manual reduction of twin embryos in dairy cattle. J Vet Med A Physiol Pathol Clin Med 52, 199-201.
53. López-Gatius F, Camón-Urgel J, 1991: Confirmation of estrus rates by palpation per rectum of genital organs in normal repeat dairy cows. Zentralbl Veterinarmed A 38, 553-556.
54. López-Gatius F, Hunter RHF, 2005: Spontaneous reduction of advanced twin embryos: its occurrence and clinical relevance in dairy cattle. Theriogenology 63, 118-125.
55. López-Gatius F, Labèrnia J, Santolaria P, López-Bejar M, Rutllant J, 1996: Effect of reproductive disorders previous to conception on pregnancy attrition in dairy cows. Theriogenology 46, 643-648.
56. López-Gatius F, Santolaria P, Yaniz J, Rutllant J, López-Béjar M, 2002: Factors affecting pregnancy loss from gestation day 38 to 90 in lactating dairy cows from a single herd. Theriogenology 57, 1251-1261.
57. López-Gatius F, Santolaria P, Yániz JL, Garbayo JM, Hunter RHF, 2004a: Timing of early foetal loss for single and twin pregnancies in dairy cattle. Reprod Domest Anim 39, 429-433.
58. López-Gatius F, Pabon M, Almería S, 2004b: Neospora caninum infection does not affect early pregnancy in dairy cattle. Theriogenology 62, 606-613.
59. López-Gatius F, Santolaria P, Yániz JL, Hunter RHF, 2004c: Progesterone supplementation during the early fetal period reduces pregnancy loss in high-yielding dairy cattle. Theriogenology 62, 1529-1535.
60. López-Gatius F, López-Béjar M, Fenech M, Hunter RHF, 2005: Ovulation failure and double ovulation in dairy cattle: risk factors and effects. Theriogenology 63, 1298-1307.
61. López-Gatius F, Santolaria P, Martino A, Delétang F, De Rensis F, 2006: The effects of GnRH treatment at the time of AI and 12 days later on reproductive performance of high producing dairy cows during the warm season in northeastern Spain. Theriogenology 65, 820-830.
62. López-Gatius F, Szenci O, Bech-Sàbat G, García-Ispierto I, Serrano B, Santolaria P, Yániz J, 2009: Factors of non-infectious nature affecting late embryonic and early foetal loss in high producing dairy herís in north-eastern Spain. Magy Allatorvosok Lapja 131, 515-531.
63. Mahesh VB, Brann DW, Hendry LB, 1996: Diverse modes of action of progesterone and its metabolites. J Steroid Biochem Mol Biol 56, 209-219.
64. Mann GE, Lamming GE, 1999: The influence of progesterone during early pregnancy in cattle. Reprod Domest Anim. 34, 269-274.
65. McDougall S, Rhodes FM, Verkerk GA, 2005: Pregnancy loss in dairy cattle in the Waikato region of New Zealand. N Z Vet J 53, 279-287.
66. McEvoy TG, Robinson JJ, Ashworth CJ, Rooke JA, Sinclair KD, 2001: Feed and forage toxicants affecting embryo survival and fetal development. Theriogenology 55, 113-129.
67. Morris D, Diskin M, 2008: Effect of progesterone on embryo survival. Animal 2, 1112-1119.
68. Nielen M, Schukken YH, Scholl DT, Wilbrink HJ, Brand A, 1989: Twinning in dairy cattle: a study of risk factors and effects. Theriogenology 32, 845-862.
69. Niswender GD, Juengel JL, Silva PJ, Rollyson MK, McIntush EW, 2000: Mechanisms controlling the function and life span of the corpus luteum. Physiol Rev 80, 1-29.
70. Pegorer MF, Vasconcelos JLM, Trinca LA, Hansen PJ, Barros CM, 2007: Influence of sire and sire breed (Gyr versus Holstein) on establishment of pregnancy and embryonic loss in lactating Holstein cows during summer heat stress. Theriogenology 67, 692-697.
71. Peters AR, 1996: Embryo mortality in the cow. Anim Breed Abs 64, 587-598.
72. Rabiee AR, Macmillan KL, Schwarzenberger F, 2001: The effect of level of feed intake on progesterone clearance rate by measuring faecal progesterone metabolites in grazing dairy cows. Anim Reprod Sci 67, 205-214.
73. Rabiee AR, Macmillan KL, Schwarzenberger F, Wright PJ, 2002: Effects of level of feeding and progesterone dose on plasma and faecal progesterone in ovariectomised cows. Anim Reprod Sci 73, 185-195.
74. Rajamahedran R, Sianangama PC, 1992: Effect of human chorionic gonadotropin on dominant follicles in cows: formation of accessory corpora lutea, progesterone production and pregnancy rates. J Reprod Fertil 95, 577-584.
75. Rhinehart JD, Starbuck-Clemmer MJ, Flores JA, Milvae RA, Yao J, Poole DH, Inskeep EK, 2009: Low peripheral progesterone and late embryonic/early fetal loss in suckled beef and lactating dairy cows. Theriogenology 71, 480-490.
76. Riding GA, Lehnert SA, French AJ, Hill JR, 2008: Conceptus-related measurements during the first trimester of bovine pregnancy. Vet J 175, 266-272.
77. Rivera H, Lopez H, Fricke PM, 2005: Use of intravaginal progesterone-releasing inserts in a synchronization protocol before timed AI and for synchronizing return to estrus in Holstein heifers. J Dairy Sci 88, 957-968.
78. Sangsritavong S, Combs DK, Sartori R, Armentano LE, Wiltbank MC, 2002: High feed intake increases liver blood flow and metabolism of progesterone and estradiol-17β in dairy cattle. J Dairy Sci 85, 2831-2842.
79. Santolaria P, López-Gatius F, García-Ispierto I, Bech-Sàbat G, Angulo E, Carretero T, Sánchez-Nadal JA, Yániz J, 2009: Effects of cumulative stressful and acute variation episodes of farm climate conditions on late embryo/early fetal loss in high producing dairy cows. Int J Biometeorol, doi.
80. Santos JEP, Thatcher WW, Chebel RC, Cerri RLA, Galvão KN, 2004a: The effect of embryonic death rates in cattle on the efficacy of estrus synchronization programs. Anim Reprod Sci 82, 513-535.
81. Santos JEP, Bartolome JA, Cerri RLA, Juchem SO, Hernandez O, Trigg T, Thatcher WW, 2004b: Effect of a deslorelin implant in a timed artificial insemination protocol on follicle development, luteal function and reproductive performance of lactating dairy cows. Theriogenology 61, 421-435.
82. Santos JEP, Rutigliano HM, Sa MF, 2009: Risk factors for resumption of postpartum estrous cycles and embryonic survival in lactating dairy cows. Anim Reprod Sci 110, 207-221.
83. Sawyer HR, 1995: Structural and functional properties of the corpus luteum of pregnancy. In: Scaramuzzi RJ, Nancarrow CD, Doberska C (eds), Reproduction in Domestic Ruminants III. I. J Reprod Fertil Ltd, Cambridge, pp. 97-110.
84. Schmidt BMW, Gerdes D, Feuring M, Falkenstein E, Christ M, Wehling M, 2000: Rapid, nongenomic steroid actions: a new age? Front Neuroendocrinol 21, 57-94.
85. Shore LS, Rios C, Marcus S, Bernstein M, Shemesh M, 1998: Relationship between peripheral estrogen concentrations at insemination and subsequent fetal loss in cattle. Theriogenology 50, 101-107.
86. Silke V, Diskin MG, Kenny DA, Boland MP, Dillon P, Mee JF, Sreenan JM, 2002: Extent, pattern and factors associated with late embryonic loss in dairy cows. Anim Reprod Sci 71, 1-12.
87. Silva-del-Río N, Colloton JD, Fricke PM, 2009: Factors affecting pregnancy loss for single and twin pregnancies in a high-producing dairy herd. Theriogenology 71, 1462-1471.
88. Silvestre FT, Kamimura S, Arteche AC, Bartolome J, Pancarci SM, Thatcher WW, 2009: Reproductive responses following postpartum suppression of ovarian follicular development with a deslorelin implant during summer heat stress in lactating dairy cows. Anim Reprod Sci 111, 320-337.
89. Smith DL, Stinefelt BM, Blemings KP, Wilson ME, 2006: Diet-induced alterations in progesterone clearance appear to be mediated by insulin signaling in hepatocytes. J Anim Sci 84, 1102-1109.
90. Spencer TE, Bazer FW, 2002: Biology of progesterone action during pregnancy recognition and maintenance of pregnancy. Front Biosci 7, 1879-1898.
91. Spencer TE, Johnson GA, Burghart RC, Bazer FW, 2004: Progesterone and placental hormone actions on the uterus: insights from domestic animals. Biol Reprod 71, 2-10.
92. Spencer TE, Johnson GA, Bazer FW, Burghart RC, Palmarini M, 2007: Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses. Reprod Fertil Dev 19, 65-78.
93. Starbuck MJ, Dailey RA, Inskeep EK, 2004: Factors affecting retention of early pregnancy in dairy cattle. Anim Reprod Sci 84, 27-39.
94. Sterry RA, Welle ML, Fricke PM, 2006: Treatment with gonadotropin-releasing hormone after first timed artificial insemination improves fertility in noncycling lactating dairy cows. J Dairy Sci 89, 4237-4245.
95. Stevenson JS, Pursley JR, Garverick HA, Fricke PM, Kesler DJ, Ottobre JS, Wiltbank MC, 2006: Treatment of cycling and noncycling lactating dairy cows with progesterone during ovsynch. J Dairy Sci 89, 2567-2578.
96. Stevenson JS, Portaluppi MA, Tenhouse DE, Lloyd A, Eborn DR, Kacuba S, DeJarnette JM, 2007: Interventions after artificial insemination: conception rates, pregnancy survival, and ovarian responses to gonadotropin-releasing hormone, human chorionic gonadotropin, and progesterone. J Dairy Sci 90, 331-340.
97. Stevenson JS, Tiffany SM, Inskeep EK, 2008: Maintenance of pregnancy in dairy cattle after treatment with human chorionic gonadotropin or gonadotropin-releasing hormone. J Dairy Sci 91, 3092-3101.
98. Stormshak F, Bishop CV, 2008: Board-invited review: estrogen and progesterone signaling: genomic and nongenomic actions in domestic ruminants. J Anim Sci 86, 299-315.
99. Szekeres-Bartho J, Barakonyi A, Par G, Polgar B, Palkovics T, Szereday L, 2001: Progesterone as an immunomodulatory molecule. Int Immunopharmacol 1, 1037-1048.
100. Thatcher WW, Macmillan KL, Hansen PJ, Drost M, 1989: Concepts for regulation of corpus luteum function by the conceptus and ovarian follicles to improve fertility. Theriogenology 31, 149-164.
101. Vanroose G, De Kruif A, Van Soom A, 2000: Embryonic mortality and embryo-pathogen interactions. Anim Reprod Sci 60-61, 131-143.
102. Vasconcelos JLM, Sangsritavong S, Tsai SJ, Wiltbank MC, 2003: Acute reduction in serum progesterone concentrations after feed intake in dairy cows. Theriogenology 60, 795-807.
103. Villarroel A, Martino A, BonDurant RH, Déletang F, Sischo WM, 2004: Effect of post-insemination supplementation with PRID on pregnancy in repeat-breeder Holstein cows. Theriogenology 61, 1513-1520.
104. Wiltbank M, Lopez H, Sartori R, Sangsritavong S, Gümen A, 2006: Changes in reproductive physiology of lactating dairy cows due to elevated steroid metabolism. Theriogenology 65, 17-29.
105. Wolf E, Arnold GJ, Bauersachs S, Beier HM, Blum HM, Einspanier R, Frölich T, Herrler A, Hiendleder S, Kölle S, Prelle K, Reichenbach H-D, Stojkovic M, Wenigerkind H, Sinowatz F, 2003: Embryo-maternal communication in bovine - Strategies for deciphering a complex cross-talk. Reprod Domest Anim 38, 276-289.