Fluoxetine-induced decrements in sexual responses of female rats and hamsters are reversed by 3α,5α-THP

Journal of Sexual Medicine

Volumn 7, Issue 8, 2010, Pages 2670-2680

  Frye, Cheryl A ^a   Rhodes, Madeline E ^b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b MCDANIEL COLLEGE   (United States)

Author keywords

Anti depressant; Fluoxetine Associated Sexual Dysfunction; Lordosis; Neurosteroids; Sexual Function; SSRI

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; FLUOXETINE;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; FEMALE; HAMSTER; LORDOSIS; MALE; MATING; NONHUMAN; PRIORITY JOURNAL; RAT; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; SYSTEMIC THERAPY; VENTRAL TEGMENTUM;

EID: 77955235003     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.01814.x     Document Type: Article

References (67)

1. Goddard AW, Shekhar A, Whiteman AF, McDougle CJ. Serotoninergic mechanisms in the treatment of obsessive-compulsive disorder. Drug Discov Today 2008, 13:325-32.
2. Pelissolo A. Efficacy and tolerability of escitalopram in anxiety disorders: A review. Encephale 2008, 34:400-8.
3. Shah NR, Jones JB, Aperi J, Shemtov R, Karne A, Borenstein J. Selective serotonin reuptake inhibitors for premenstrual syndrome and premenstrual dysphoric disorder: A meta-analysis. Obstet Gynecol 2008, 111:1175-82.
4. Ayd FJ. Pertinent medical intelligence: Fluoxetine's impact on sexual function. Md Med J 1995, 44:526-7.
5. Kennedy SH, Rizvi S. Sexual dysfunction, depression, and the impact of antidepressants. J Clin Psychopharmacol 2009, 29:157-64.
6. Corona G, Ricca V, Bandini E, Mannucci E, Lotti F, Boddi V, Rastrelli G, Sforza A, Faravelli C, Forti G, Maggi M. Selective serotonin reuptake inhibitor-induced sexual dysfunction. J Sex Med 2009, 6:1259-69.
7. Csoka AB, Bahrick A, Mehtonen OP. Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors. J Sex Med 2008, 5:227-33.
8. Madeo B, Bettica P, Milleri S, Balestrieri A, Granata AR, Carani C, Rochira V. The effects of citalopram and fluoxetine on sexual behavior in healthy men: Evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double-dummy, parallel group study. J Sex Med 2008, 5:2431-41.
9. Safarinejad MR. Reversal of SSRI-induced female sexual dysfunction by adjunctive bupropion in menstruating women: A double-blind, placebo-controlled and randomized study. J Psychopharmacol 2010, Jan 15 [Epub ahead of print] doi:10.1177/0269881109351966
10. Bancroft J, Loftus J, Long JS. Distress about sex: A national survey of women in heterosexual relationships. Arch Sex Behav 2003, 32:193-211.
11. Leiblum SR, Koochaki PE, Rodenberg CA, Barton IP, Rosen RC. Hypoactive sexual desire disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHeS). Menopause 2006, 13:46-56.
12. Rosen RC, Lane RM, Menza M. Effects of SSRIs on sexual function: A critical review. J Clinical Psychopharmacol 1999, 19:67-85.
13. Kessler RC, McGonagle KA, Nelson CB, Hughes M, Swartz M, Blazer DG. Sex and depression in the National Comorbidity Survey. II: Cohort effects. J Affect Disord 1994, 30:15-26.
14. Shen WW, Hsu JH. Female sexual side effects associated with selective serotonin reuptake inhibitors: A descriptive clinical study of 33 patients. Int J Psychiatry Med 1995, 25:239-48.
15. Balon R. SSRI-associated sexual dysfunction. Am J Psychiatry 2006, 163:1504-9.
16. Hu XH, Bull SA, Hunkeler EM, Ming E, Lee JY, Fireman B, Markson LE. Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: Patient report versus physician estimate. J Clin Psychiatry 2004, 65:959-65.
17. Frohlich P, Meston CM. Fluoxetine-induced changes in tactile sensation and sexual functioning among clinically depressed women. J Sex Marital Ther 2005, 31:113-28.
18. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: Prevalence and predictors. JAMA 1999, 281:537-44.
19. Nelson JC, Portera L, Leon AC. Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine. J Clin Psychiatry 2005, 66:1409-14.
20. Terao T. Female sexual dysfunction and antidepressant use. Am J Psychiatry 2001, 158:326-7.
21. Uphouse L, Hensler JG, Sarkar J, Grossie B. Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats. Brain Res 2006, 1072:79-90.
22. Frye CA, Rhodes ME. Zaprinast, a phosphodiesterase 5 inhibitor, overcomes sexual dysfunction produced by fluoxetine, a selective serotonin reuptake inhibitor in hamsters. Neuropsychopharmacol 2003, 28:310-6.
23. Sarkar J, Hiegel C, Ginis GE, Hilbun E, Uphouse L. Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behavior. Brain Res 2008, 1190:56-64.
24. Lavoie HA, King SR. Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1, and HSD3B. Exp Biol Med 2009, 234:880-907. Maywood
25. Blaustein JD, Tetel MJ, Ricciardi KH, Delville Y, Turcotte JC. Hypothalamic ovarian steroid hormone-sensitive neurons involved in female sexual behavior. Psychoneuroendocrinol 1994, 19:505-16.
26. Rubin BS, Barfield RJ. Induction of estrous behavior in ovariectomized rats by sequential replacement of estrogen and progesterone to the ventromedial hypothalamus. Neuroendocrinology 1983, 89:32-8.
27. Rubin BS, Barfield RJ. Priming of estrous responsiveness by implants of 17β-estradiol in the ventromedial hypothalamic nucleus of the female rat. Endocrinology 1980, 106:504-9.
28. Rubin BS, Barfield RJ. Progesterone in the ventromedial hypothalamus facilitates estrous behavior in ovariectomized, estrogen primed rats. Endocrinology 1983, 113:797-804.
29. Frye CA, Rhodes ME, Petralia SM, Walf AA, Sumida K, Edinger KL. 3α-hydroxy-5α-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Neuroscience 2006, 138:1007-14.
30. King SR. Emerging roles for neurosteroids in sexual behavior and function. J Androl 2008, 29:524-33.
31. King SR, Lamb DJ. Why we lose interest in sex: Do neurosteroids play a role? Sex Reprod Menopause 2006, 4:20-3.
32. Frye CA, Walf AA. Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways. Steroids 2008, 73:906-13.
33. McCarthy MM, Felzenberg E, Robbins A, Pfaff DW, Schwartz-Giblin S. Infusions of diazepam and allopregnanolone into the midbrain central gray facilitate open-field behavior and sexual receptivity in female rats. Horm Behav 1995, 29:279-95.
34. King SR, Manna PR, Ishii T, Syapin PJ, Ginsberg SD, Wilson K, Walsh LP, Parker KL, Stocco DM, Smith RG, Lamb DJ. An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J Neurosci 2002, 22:10613-20.
35. King SR, Ginsberg SD, Ishii T, Smith RG, Parker KL, Lamb DJ. The steroidogenic acute regulatory protein is expressed in steroidogenic cells of the day-old brain. Endocrinology 2004, 145:4775-80.
36. Mellon SH, Deschepper CF. Neurosteroid biosynthesis: Genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res 1993, 629:283-92.
37. Frye CA, Walf AA, Rhodes ME, Harney JP. Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5α-reductase. Brain Res 2004, 1004:116-24.
38. Petralia SM, Jahagirdar V, Frye CA. Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus. J Neuroendocrinol 2005, 17:545-52.
39. Frye CA. The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents. Brain Res Brain Res Rev 2001, 37:201-22.
40. Frye CA, Petralia SM. Mitochondrial benzodiazepine receptors in the ventral tegmental area modulate sexual behaviour of cycling or hormone-primed hamsters. J Neuroendocrinol 2003, 15:677-86.
41. Mellon SH, Griffin LD. Synthesis, regulation, and function of neurosteroids. Endocr Res 2002, 28:463.
42. Petralia SM, Frye CA. In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters. Psychopharmacology (Berl) 2005, 178:174-82.
43. Paxinos G, Watson C. The rat brain 1986, New York, Academic Press
44. Morin LP, Wood RI. A stereotaxic atlas of the golden hamster brain 2001, San Diego, CA, Academic Press
45. Frye CA, Petralia SM, Rhodes ME, Stein B. Fluoxetine may influence lordosis of rats through effects on midbrain 3α,5α-THP concentrations. Ann N Y Acad Sci 2003, 1007:37-41.
46. Hardy DF, Debold JF. Effects of mounts without intromission upon the behavior of female rats during the onset of estrogen-induced heat. Physiol Behav 1971, 7:643-5.
47. Grant EC. An analysis of the social behaviour of the male laboratory rat. Behaviour 1963, 21:260-81.
48. Taylor G, Bardgett M, Csernansky J, Early T, Haller J, Scherrer J, Womack S. Male reproductive systems under chronic fluoxetine or trimipramine treatment. Physiol Behav 1996, 59:479-85.
49. Yells DP, Prendergast MA, Hendricks SE, Miller ME. Monoaminergic influences on temporal patterning of sexual behavior in male rats. Physiol Behav 1995, 58:847-52.
50. Taylor GT, Farr S, Klinga K, Weiss J. Chronic fluoxetine suppresses circulating estrogen and the enhanced spatial learning of estrogen-treated ovariectomized rats. Psychoneuroendocrinol 2004, 29:1241-9.
51. Matuszczyk JV, Larsson K, Eriksson E. Subchronic administration of fluoxetine impairs estrous behavior in intact female rats. Neuropsychopharmacol 1998, 19:492-8.
52. Thrall KD, Vucelick ME, Gies RA, Benson JM. Comparative metabolism of carbon tetrachloride in rats, mice, and hamsters using gas uptake and PBPK modeling. J Toxicol Environ Health 2000, 60:531-48.
53. Engel SR, Grant KA. Neurosteroids and behavior. Int Rev Neurobiol 2001, 46:321-48.
54. Griffin LD, Mellon SH. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Proc Natl Acad Sci U S A 1999, 96:13512-7.
55. Chappell PE, Levine JE. Stimulation of gonadotropin-releasing hormone surges by estrogen. I. Role of hypothalamic progesterone receptors. Endocrinology 2000, 141:1477-85.
56. El-Etr M, Akwa Y, Fiddes RJ, Robel P, Baulieu EE. A progesterone metabolite stimulates the release of gonadotropin-releasing hormone from GT1-1 hypothalamic neurons via the gamma-aminobutyric acid type A receptor. Proc Natl Acad Sci U S A 1995, 92:3769-73.
57. Sullivan SD, Moenter SM. Neurosteroids alter gamma-aminobutyric acid postsynaptic currents in gonadotropin-releasing hormone neurons: A possible mechanism for direct steroidal control. Endocrinology 2003, 144:4366-75.
58. Micevych P, Sinchak K, Mills RH, Tao L, LaPolt P, Lu JK. The luteinizing hormone surge is preceded by an estrogen-induced increase of hypothalamic progesterone in ovariectomized and adrenalectomized rats. Neuroendocrinology 2003, 78:29-35.
59. Soma KK, Sinchak K, Lakhter A, Schlinger BA, Micevych PE. Neurosteroids and female reproduction: Estrogen increases 3β-HSD mRNA and activity in rat hypothalamus. Endocrinology 2005, 146:4386-90.
60. Genazzani AR, Palumbo MA, de Micheroux AA, Artini PG, Criscuolo M, Ficarra G, Guo AL, Benelli A, Bertolini A, Petraglia F, Purdy RH. Evidence for a role for the neurosteroid allopregnanolone in the modulation of reproductive function in female rats. Eur J Endocrinol 1995, 133:375-80.
61. Genazzani AR, Stomati M, Bernardi F, Luisi S, Casarosa E, Puccetti S, Genazzani AD, Palumbo M, Luisi M. Conjugated equine estrogens reverse the effects of aging on central and peripheral allopregnanolone and β-endorphin levels in female rats. Fertil Steril 2004, 81:757-66.
62. Beck CA, Wolfe M, Murphy LD, Wiebe JP. Acute, nongenomic actions of the neuroactive gonadal steroid, 3α-hydroxy-4-pregnen-20-one (3αHP), on FSH release in perifused rat anterior pituitary cells. Endocrine 1997, 6:221-9.
63. Wiebe JP, Boushy D, Wolfe M. Synthesis, metabolism and levels of the neuroactive steroid, 3α-hydroxy-4-pregnen-20-one (3αHP), in rat pituitaries. Brain Res 1997, 764:158-66.
64. Liu T, Wimalasena J, Bowen RL, Atwood CS. Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expression. J Neurochem 2007, 100:1329-39.
65. More L. Mouse major urinary proteins trigger ovulation via the vomeronasal organ. Chem Senses 2006, 31:393-401.
66. Giraldi A, Marson L, Nappi R, Pfaus J, Traish AM, Vardi Y, Goldstein I. Physiology of female sexual function: Animal models. J Sex Med 2004, 1:237-53.
67. Pfaus JG. Pathways of sexual desire. J Sex Med 2009, 6:1506-33.