Stiff-person syndrome: Persistent elevation of glutamic acid decarboxylase antibodies despite successful treatment with rituximab

Journal of Clinical Rheumatology

Volumn 16, Issue 5, 2010, Pages 237-239

  Bacorro, Eugene A ^a   Tehrani, Rodney ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

case report; rituximab; stiff person syndrome

Indexed keywords

ACETYLSALICYLIC ACID; BACLOFEN; CANDESARTAN; CARVEDILOL; DIAZEPAM; FELODIPINE; GLUTAMATE DECARBOXYLASE ANTIBODY; HYDROCHLOROTHIAZIDE; INSULIN GLARGINE; LEVOTHYROXINE; PREDNISONE; RITUXIMAB;

ADD ON THERAPY; ADULT; AFRICAN AMERICAN; ANTIBODY TITER; ARTICLE; CASE REPORT; DIABETES MELLITUS; DISEASE COURSE; DRUG WITHDRAWAL; HIP; HUMAN; HYPERTENSION; LEG; MALE; PRIORITY JOURNAL; SIDE EFFECT; SOMNOLENCE; STENOSIS; STIFF MAN SYNDROME; TREATMENT RESPONSE;

ANTIBODIES; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIRHEUMATIC AGENTS; GLUTAMATE DECARBOXYLASE; HUMANS; MALE; MIDDLE AGED; STIFF-PERSON SYNDROME; TREATMENT OUTCOME;

EID: 77955229461     PISSN: 10761608     EISSN: None     Source Type: Journal    
DOI: 10.1097/RHU.0b013e3181e931fa     Document Type: Article

References (15)

1. McEvoy KM. Stiff-Man Syndrome. Semin Neuro. 1991;11:197-205.
2. Lockman J, Burns T. Stiff-person syndrome. Pract Neurol. 2007;7:106-108. (Pubitemid 46578849)
3. Espay AJ, Chen R. Rigidity and spasms from autoimmune encephalomy- elopathies: stiff-person syndrome. Muscle Nerve. 2006;34:677-690.
4. Sechi GP, Barrocu M, Piluzza MG, et al. Levetiracetam in stiff-person syndrome. J Neurol. 2008;255:1721-1725.
5. Brashear HR, Phillips LH. Autoantibodies to GABAergic neurons and response to plasmapheresis in stiff-man syndrome. Neurology. 1991;41:1588-1592.
6. Dalakas MC, Fujii M, Li M, et al. High-dose intravenous immune globulin for stiff-person syndrome. N Engl J Med. 2001;345:1870-1876.
7. Baker MR, Das M, Isaacs J, et al. Treatment of stiff-person syndrome with rituximab. J Neurol Neurosurg Psychiatry. 2005;76:999-1001.
8. Wilt T, Scherbaum WA, Gleichmann H, et al. Comparison of a new anti- glutamic acid decarboxylase (GAD) enzyme-linked immunosorbent assay (ELISA) with radioimmunoassay methods: a multicenter study. Horm Metab Res. 1997;29:403-406.
9. Murinson BB. Stiff-person syndrome. Neurologist. 2004;10:131-137.
10. Levy LM, Levy-Reis I, Fujii M, et al. Brain y-aminobutyric acid changes in stiff-person syndrome. Arch Neurol. 2005;62:970-974.
11. Murinson BB, Guarnaccia JB. Stiff-person syndrome with amphiphysin antibodies: distinctive features of a rare disease. Neurology. 2008;71:1955-1958.
12. Yanaba K, Bouaziz JD, Matsushita T, et al. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008;223:284-299.
13. Pescovitz MD. Rituximab, an anti-CD20 monoclonal antibody: history and mechanism of action. Am J Transplant. 2006;6:859-866.
14. Bouaziz JD, Yanaba K, Venturi GM, et al. Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice. Proc Natl Acad Sci USA. 2007;104:20878-20883.
15. Vigna-Perez V, Hernandez-Castro B, Paredes-Saharopulos O, et al. Clinical and immunological effects of rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study. Arthritis Res Ther. 2006;8:R83.