Measurements of respirable dust and nanoparticle concentrations in a titanium dioxide pigment production factory

Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering

Volumn 45, Issue 10, 2010, Pages 1227-1233

  Huang, Cheng Hsiung ^a   Tai, Chih Yuan ^a   Huang, Cheng Y U ^b   Tsai, Chuen Jinn ^b   Chen, Chun Wan ^c   Chang, Cheng Ping ^c   Shih, Tung Sheng ^c  

^a YUANPEI UNIVERSITY   (Taiwan)

^b NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^c INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH   (Taiwan)

Author keywords

Nanoparticles; Particle concentration; Respirable dust; Titanium dioxide

Indexed keywords

CHEMICAL PLANTS; DUST; METAL ANALYSIS; NANOPARTICLES; OCCUPATIONAL RISKS; OXIDES; PARTICLE SIZE; SIZE DISTRIBUTION; TITANIUM; TITANIUM DIOXIDE;

IMPACTORS; METALLIC CONTENT; NANOPARTICLE CONCENTRATIONS; NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTHS; NUMBER CONCENTRATION; PARTICLE CONCENTRATIONS; RESPIRABLE DUST; RESPIRABLE PARTICLES; SAMPLING DEVICES; SAMPLING LOCATION; SAMPLING RESULTS; TITANIUM DIOXIDE PIGMENTS;

CONCENTRATION (PROCESS);

NANOPARTICLE; PIGMENT; TITANIUM DIOXIDE; AIR POLLUTANT; COLORING AGENT; DUST; TITANIUM;

AIR MONITORING; AIR QUALITY; ARTICLE; CHEMICAL INDUSTRY; OCCUPATIONAL SAFETY; PARTICLE SIZE; SUSPENDED PARTICULATE MATTER; WORKROOM AIR; AIR POLLUTANT; ANALYSIS; DUST; EXPOSURE; HUMAN; INDUSTRY; MATERIALS; SYNTHESIS; TIME;

AIR POLLUTANTS, OCCUPATIONAL; COLORING AGENTS; DUST; HUMANS; INDUSTRY; INHALATION EXPOSURE; MANUFACTURED MATERIALS; NANOPARTICLES; PARTICLE SIZE; TIME FACTORS; TITANIUM;

EID: 77955213209     PISSN: 10934529     EISSN: 15324117     Source Type: Journal    
DOI: 10.1080/10934529.2010.493792     Document Type: Article

References (32)

1. Wang, J.J.; Sanderson, B.J.S.; Wang, H. Cyto- and genotoxicity of ultrafine TÍO2 particles in cultured human lymphoblastoid cells. Mutat. Res. 2007, 628, 99-06.
2. Nordman, H.; Berlin, M. Titanium. In Handbook on the Toxicology of Metals; L. Friberg, G.F.; Nordberg; Vouk, V.B., Eds., Elsevier, Amsterdam, 1986.
3. Lomer, M.C.; Thompson, R.P.; Powell, J.J. Fine and ultrafine particles of the diet: influence on the mucosal immune response and association with Crohn's disease. Proc. Nutr. Soc. 2002, 61, 123130.
4. Gelis, C.; Girard, S.; Mavon, A.; Delverdier, M.; Paillous, N.; Vicendo, P. Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models. Photodermatol. Photoimmunol. Photomed. 2003,19, 242-253.
5. Liao, C.-M.; Chiang, Y.-H.; Chio, C.-P. Assessing the airborne titanium dioxide nanoparticle-related exposure hazard at workplace. J. Hazard. Mater. 2009,162, 57-65.
6. Liao, C.-M.; Chiang, Y.-H.; Chio, C.-P. Model-based assessment for human inhalation exposure risk to airborne nano/fine titanium dioxide particles. Sci. Total Environ. 2008, 407, 165-177.
7. Garabrant, D.H.; Fine, L.J.; Oliver, C.; Bernstein, L.; Peters, J.M. Abnormalities of pulmonary function and pleural disease among titanium metal production workers. Scand. J. Work Environ. Health 1987,13, 47-51.
8. Fayerweather, W.E.; Karns, M.E.; Gilby, PG; Chen, J.L. Epidemiologic study of lung cancer mortality in workers exposed to titanium tetrachloride. J. Occup. Environ. Med. 1992, 34, 164-169.
9. Boffetta, P; Gaborieau, V.; Nadon, L.; Parent, M.E.; Weiderpass, E.; Siemiatycki, J. Exposure to titanium dioxide and risk of lung cancer in a population-based study from Montreal Scand. J. Work Environ. Health 2001, 27, 227-232.
10. Dharshana, K.G.T.; Coowanitwong, N. Ambient PM 10 and respiratory illnesses in Colombo city, Sri Lanka. Journal of Environmental Science and Health Part A.2008, 43, 1064-1070.
11. Baggs, R.B.; Ferin, J.; Oberdorster, G Regression of pulmonary lesions produced by inhaled titanium dioxide in rats. Vet. Pathol. 1997, 34, 592-597.
12. Rahman, Q.; Lohani, M.; Dopp, E.; Pemsel, H.; Jonas, L.; Weiss, D. G.; Schiffmann, D. Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. Environ. Health Perspect. 2002,110, 797-800.
13. Kreilgaard, M. Influence of microemulsions on cutaneous drug delivery. Adv. Drug Deliv. Rev. 2002, 54, S77-S98.
14. Lademann, J.; Weigmann, H.; Rickmeyer, C.; Barthelmes, H.; Schaefer, H.; Mueller, G.; Sterry, W Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol. Appl. Skin Physiol. 1999,12, 247-256.
15. Tinkle, S.S.; Antonini, J.M.; Rich, B.A.; Roberts, J.R.; Salinen, R.; DePree, K.; Adkins, E.J. Skin as a route of exposure and sensitization in chronic beryllium disease. Environ. Health Perspect. 2003, 111,1202-1208.
16. Peters, K.; Unger, R.E.; Kirkpatrick, C.J.; Gatti, A.M.; Monad, E. Effects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation and inflammation. J. Mater. Sci. Mater. Med. 2004,15, 321-325.
17. Nel, A. Air pollution-related illness: effects of particles. Science 2005, 306, 804-806.
18. Peters, A.; Wichmann, H.E.; Tuch, T.; Heinrich, J.; Heyder, J. Respiratory effects are associated with the number of ultrafine particles. Am. J. Respir. Crit. Care Med. 1997,155, 1376-1383.
19. Jaques, P.A.; Chong, S.K. Measurement of total lung deposition of inhaled ultrafine particles in healthy men and women. Inhal. Toxicol. 2000,12, 715-731.
20. Brown, J.S.; Zeman, K.L.; Bennett, WD. Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am. J. Resp. Crit. Care Med. 2002,166, 1240-1247.
21. 2) by inhalation for two years. Toxicol. Appl. Pharmacol. 1985, 79, 179-192.
22. Cullen, R.T.; Tran, C.L.; Buchanan,D.; Davis, J.M.; Searl,A.;Jones, A.D.; Donaldson, K. Inhalation of poorly soluble particles. I. Differences in inflammatory response and clearance during exposure. Inhal. Toxicol. 2000,12, 1089-1111.
23. Bermudez, E.; Mangum, J.B.; Asgharian, B.; Wong, B.A.; Reverdy, E.E.; Janszen, D.B.; Hext, P.M.; Warheit, D.B.; Everitt, J.I. Longterm pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. Toxicol. Sci. 2002, 70, 86-97.
24. Ferin, J., Oberdorster, G.; Penney, D.P Pulmonary retention of ultrafine and fine particles in rats. Am. J. Respir. Cell Mol. Biol. 1992, 6, 535-542.
25. Hext, P.M. Current perspectives on particulate induced pulmonary tumours. Human Exp. Toxicol. 1994,13, 700-715.
26. National Institute for Occupational Safety and Health (NIOSH). NIOSH current intelligence bulletin: evaluation of health hazard and recommendations for occupational exposure to titanium dioxide, DHHS (NIOSH) publication. Cincinnati, Ohio, 2005.
27. Fryzek, J.P; Chadda, B.; Marano, D.; White, K.; Schweitzer, S.; McLaughlin, J.K. A cohort mortality study among titanium dioxide manufacturing workers in the United States. J. Occup. Environ. Med. 2003, 45, 400-409.
28. Boffetta, P; Soutar, A.; Cherrie, J.W.; Granath, F; Andersen, A.; Anttila, A. Mortality among workers employed in the titanium dioxide production industry in Europe. Cancer Causes Control. 2004,15, 697-706.
29. Tsai, C.-J.; Shiau, H.-G; Shih, T-S. Field study of the accuracy of two respirable sampling cyclones. Aerosol Sci. Technol. 1999, 31, 463-472.
30. National Institute for Occupational Safety and Health (NIOSH). Elements by ICP: Method 7300, Issue 2, NIOSH Manual of Analytical Methods (NMAM), Fourth Edition,1994.
31. Hinds, W.C. Aerosol technology; John Wiley and Sons, New York, 1999.
32. 1, PM2.5, and PM10 in bag filling areas of carbon black production. J. Occup. Environ. Hyg. 2004, 1, 660-671.