Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: A microarray study

BMC Medical Genomics

Volumn 3, Issue , 2010, Pages

  Wolfs, Marcel Gm ^a   Rensen, Sander S ^b   Bruin Van Dijk, Elinda J ^a   Verdam, Froukje J ^b   Greve, Jan Willem ^b   Sanjabi, Bahram ^a   Bruinenberg, Marcel ^a   Wijmenga, Cisca ^a   Van Haeften, Timon W ^a,c   Buurman, Wim A ^b   Franke, Lude ^a,d   Hofker, Marten H ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; FATTY ACID ESTER; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRANSCRIPTOME; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BODY MASS; COMORBIDITY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENE FUNCTION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; INTRAABDOMINAL FAT; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; OBESITY; PRIORITY JOURNAL; SUBCUTANEOUS FAT; ADOLESCENT; BLOOD; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORK; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED;

ADOLESCENT; ADULT; AGED; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL, HDL; FEMALE; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; HUMANS; INSULIN; INTRA-ABDOMINAL FAT; LIPID METABOLISM; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; OBESITY; SUBCUTANEOUS FAT; TRIGLYCERIDES;

EID: 77955204062     PISSN: None     EISSN: 17558794     Source Type: Journal    
DOI: 10.1186/1755-8794-3-34     Document Type: Article

References (42)

1. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. GR Hajer TW van Haeften FL Visseren, Eur Heart J 2008 29 2959 2971 10.1093/eurheartj/ehn387 18775919
2. Neutrophil activation in morbid obesity, chronic activation of acute inflammation. J Nijhuis SS Rensen Y Slaats FM van Dielen WA Buurman JW Greve, Obesity (Silver Spring) 2009 17 2014 2018 10.1038/oby.2009.113 19390527
3. Obesity and low-grade inflammation: a paediatric perspective. CS Tam K Clement LA Baur J Tordjman, Obes Rev 2010 11 118 126 10.1111/j.1467-789X.2009. 00674.x 19845868
4. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. GS Hotamisligil NS Shargill BM Spiegelman, Science 1993 259 87 91 10.1126/science.7678183 7678183
5. From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. CA Curat A Miranville C Sengenes M Diehl C Tonus R Busse A Bouloumie, Diabetes 2004 53 1285 1292 10.2337/diabetes.53.5. 1285 15111498
6. Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. I Harman-Boehm M Bluher H Redel N Sion-Vardy S Ovadia E Avinoach I Shai N Kloting M Stumvoll N Bashan A Rudich, J Clin Endocrinol Metab 2007 92 2240 2247 10.1210/jc.2006-1811 17374712
7. Obesity is associated with macrophage accumulation in adipose tissue. SP Weisberg D McCann M Desai M Rosenbaum RL Leibel AW Ferrante Jr, J Clin Invest 2003 112 1796 1808 14679176
8. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. H Xu GT Barnes Q Yang G Tan D Yang CJ Chou J Sole A Nichols JS Ross LA Tartaglia H Chen, J Clin Invest 2003 112 1821 1830 14679177
9. The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. M Bluher, Curr Opin Lipidol 2010 21 38 43 10.1097/MOL. 0b013e3283346ccc 19915462
10. Evidence for a regional component of body fatness in the association with serum lipids in men and women. JP Despres C Allard A Tremblay J Talbot C Bouchard, Metabolism 1985 34 967 973 10.1016/0026-0495(85)90147-7 4046840
11. Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. F Capel E Klimcakova N Viguerie B Roussel M Vitkova M Kovacikova J Polak Z Kovacova J Galitzky JJ Maoret, et al. Diabetes 2009 58 1558 1567 10.2337/db09-0033 19401422
12. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. C Henegar J Tordjman V Achard D Lacasa I Cremer M Guerre-Millo C Poitou A Basdevant V Stich N Viguerie, et al. Genome Biol 2008 9 14 10.1186/gb-2008-9-1-r14 18208606
13. Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians. S Nair YH Lee E Rousseau M Cam PA Tataranni LJ Baier C Bogardus PA Permana, Diabetologia 2005 48 1784 1788 10.1007/s00125-005-1868-2 16034612
14. Expansion and contraction: treating diabetes with bariatric surgery. AB Goldfine SE Shoelson V Aguirre, Nat Med 2009 15 616 617 10.1038/nm0609-616 19498374
15. Macrophage inhibitory factor, plasminogen activator inhibitor-1, other acute phase proteins, and inflammatory mediators normalize as a result of weight loss in morbidly obese subjects treated with gastric restrictive surgery. FM van Dielen WA Buurman M Hadfoune J Nijhuis JW Greve, J Clin Endocrinol Metab 2004 89 4062 4068 10.1210/jc.2003-032125 15292349
16. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. EM Brunt CG Janney AM Di Bisceglie BA Neuschwander-Tetri BR Bacon, Am J Gastroenterol 1999 94 2467 2474 10.1111/j.1572-0241.1999.01377.x 10484010
17. Cluster analysis and display of genome-wide expression patterns. MB Eisen PT Spellman PO Brown D Botstein, Proc Natl Acad Sci USA 1998 95 14863 14868 10.1073/pnas.95.25.14863 9843981
18. PANTHER: a library of protein families and subfamilies indexed by function. PD Thomas MJ Campbell A Kejariwal H Mi B Karlak R Daverman K Diemer A Muruganujan A Narechania, Genome Res 2003 13 2129 2141 10.1101/gr.772403 12952881
19. Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools. PD Thomas A Kejariwal N Guo H Mi MJ Campbell A Muruganujan B Lazareva-Ulitsky, Nucleic Acids Res 2006 34 645 650 10.1093/nar/gkl229 16912992
20. KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa S Goto, Nucleic Acids Res 2000 28 27 30 10.1093/nar/28.1.27 10592173
21. A methodology for global validation of microarray experiments. M Miron OZ Woody A Marcil C Murie R Sladek R Nadon, BMC Bioinformatics 2006 7 333 10.1186/1471-2105-7-333 16822306
22. AutoPrime: selecting primers for expressed sequences. G Wrobel F Kokocinski P Lichter, Genome biology 2004 5 11 p19 10.1186/gb-2004-5-5-p11
23. The Fc gamma RI receptor signals through the activation of hck and MAP kinase. DL Durden HM Kim B Calore Y Liu, J Immunol 1995 154 4039 4047 7535819
24. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. AV Wang PR Scholl RS Geha, J Exp Med 1994 180 1165 1170 10.1084/jem.180.3.1165 8064233
25. Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling. DL Durden YB Liu, Blood 1994 84 2102 2108 7522622
26. Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase. PA Kiener BM Rankin AL Burkhardt GL Schieven LK Gilliland RB Rowley JB Bolen JA Ledbetter, J Biol Chem 1993 268 24442 24448 8226994
27. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. JF Charles MB Humphrey X Zhao E Quarles MC Nakamura A Aderem WE Seaman KD Smith, Infect Immun 2008 76 2439 2447 10.1128/IAI.00115-08 18391000
28. TREMs in the immune system and beyond. M Colonna, Nat Rev Immunol 2003 3 445 453 10.1038/nri1106 12776204
29. Signalling adaptors used by Toll-like receptors: an update. EF Kenny LA O'Neill, Cytokine 2008 43 342 349 10.1016/j.cyto.2008.07.010 18706831
30. Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in diabetic and healthy subjects. G Derosa A D'Angelo C Tinelli E Devangelio A Consoli R Miccoli G Penno S Del Prato S Paniga AF Cicero, Diabetes Metab 2007 33 129 134 10.1016/j.diabet.2006.11.008 17320450
31. Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages. S Hongo T Watanabe S Arita T Kanome H Kageyama S Shioda A Miyazaki, Am J Physiol Endocrinol Metab 2009 297 474 482 10.1152/ajpendo.90369.2008 19625677
32. Cellular cholesterol trafficking and compartmentalization. E Ikonen, Nat Rev Mol Cell Biol 2008 9 125 138 10.1038/nrm2336 18216769
33. Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol. M Kolz J Baumert M Muller N Khuseyinova N Klopp B Thorand C Meisinger C Herder W Koenig T Illig, BMC Med Genet 2008 9 9 10.1186/1471-2350-9-9 18298826
34. Cholesterol efflux via HDL resecretion occurs when cholesterol transport out of the lysosome is impaired. TA Pagler A Neuhofer H Laggner W Strobl H Stangl, J Lipid Res 2007 48 2141 2150 10.1194/jlr.M700056-JLR200 17620658
35. Lipoproteins, macrophage function, and atherosclerosis: beyond the foam cell? DJ Rader E Pure, Cell Metab 2005 1 223 230 10.1016/j.cmet.2005.03.005 16054067
36. TLR4 links innate immunity and fatty acid-induced insulin resistance. H Shi MV Kokoeva K Inouye I Tzameli H Yin JS Flier, J Clin Invest 2006 116 3015 3025 10.1172/JCI28898 17053832
37. Abnormal circulating levels of metalloprotease 9 and its tissue inhibitor 1 in angiographically proven peripheral arterial disease: relationship to disease severity. MH Tayebjee KT Tan RJ MacFadyen GY Lip, J Intern Med 2005 257 110 116 10.1111/j.1365-2796.2004.01431.x 15606382
38. Upregulation of macrophage endothelial lipase by toll-like receptors 4 and 3 modulates macrophage interleukin-10 and -12 production. X Wang W Jin DJ Rader, Circ Res 2007 100 1008 1015 10.1161/01.RES.0000263011.34709.c5 17347473
39. Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice. M Westerterp JF Berbee NM Pires GJ van Mierlo R Kleemann JA Romijn LM Havekes PC Rensen, Circulation 2007 116 2173 2181 10.1161/CIRCULATIONAHA.107.693382 17967778
40. Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. L Yvan-Charvet N Wang AR Tall, Arterioscler Thromb Vasc Biol 2010 30 139 143 10.1161/ATVBAHA.108.179283 19797709
41. Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. T Tchkonia M Lenburg T Thomou N Giorgadze G Frampton T Pirtskhalava A Cartwright M Cartwright J Flanagan I Karagiannides, et al. Am J Physiol Endocrinol Metab 2007 292 298 307 10.1152/ajpendo.00202.2006 16985259
42. A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men. MC Vohl R Sladek J Robitaille S Gurd P Marceau D Richard TJ Hudson A Tchernof, Obes Res 2004 12 1217 1222 10.1038/oby.2004.153 15340102