Usefulness of sweat testing for the detection of methylphenidate after fast-and extended-release drug administration: A pilot study

Therapeutic Drug Monitoring

Volumn 32, Issue 4, 2010, Pages 508-511

  Marchei, Emilia ^a   Farré, Magí ^b   Pardo, Ricardo ^b   Garcia Algar, Oscar ^c   Pellegrini, Manuela ^a   Pacifici, Roberta ^a   Pichini, Simona ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^c HOSPITAL DEL MAR   (Spain)

Author keywords

methylphenidate; ritalinic acid; sweat patch; sweat testing

Indexed keywords

METHYLPHENIDATE; RUBIFEN; UNCLASSIFIED DRUG; CENTRAL STIMULANT AGENT; DELAYED RELEASE FORMULATION; RITALINIC ACID;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG FORMULATION; DRUG MONITORING; HUMAN; HUMAN EXPERIMENT; MALE; NON INVASIVE PROCEDURE; PRIORITY JOURNAL; SINGLE DRUG DOSE; SWEAT TEST; ANALOGS AND DERIVATIVES; CHEMISTRY; DELAYED RELEASE FORMULATION; DOSE RESPONSE; PILOT STUDY; PROCEDURES; SUBSTANCE ABUSE; SWEAT; YOUNG ADULT;

CENTRAL NERVOUS SYSTEM STIMULANTS; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; METHYLPHENIDATE; PILOT PROJECTS; SUBSTANCE ABUSE DETECTION; SWEAT; YOUNG ADULT;

EID: 77955176003     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e3181e4e6f8     Document Type: Article

References (18)

1. DeVane CL, Markowitz JS, Carson SW, et al. Single-dose pharmacoki-netics of methylphenidate in CYP2D6 extensive and poor metabolizers. J Clin Psychopharmacol. 2000;20:347-349.
2. Dupont RL, Coleman. JJ, Bucher RH, et al. Characteristics and motives of college students who engage in no medical use of methylphenidate. Am J Addict. 2008;17:167-171.
3. Wilens TE, Adler LA, Adams J, et al. Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature. J Am Acad Child Adolesc Psychiatry. 2008;47:21-31.
4. Kidwell D, Holland J, Athanaselis S. Testing for drugs of abuse in saliva and sweat. J Chromatogr B. 1998;713:111-135.
5. de la Torre R, Farré M, Navarro M, et al. Clinical pharmacokinetics of amfetamine and related substances: monitoring in conventional and non-conventional matrices. Clin Pharmacokinet. 2004;43:157-185.
6. Bosker WM, Huestis MA. Oral fluid testing for drugs of abuse. Clin Chem. 2009;55:1910-1931.
7. Drummer OH. Drug testing in oral fluid. Clin Biochem Rev. 2006;27: 147-159.
8. Navarro M, Pichini S, Farré M, et al. Usefulness of saliva for measurement of 3,4-methylenedioxymethamphetamine and its metabolites: correlation with plasma drug concentrations and effect of salivary pH. Clin Chem. 2001;47:1788-1795.
9. Marchei E, Farrè M, Garcia-algar O, et al. Concentrations in oral fluid and plasma. Clin Chem. 2010;56:585-592.
10. De la Torre, Pichini S. Alternative specimens\sweat. In: Jamieson A, Moenssens A, eds. Wiley Encyclopaedia of Forensic Science. John Wiley and Sons; 2008.
11. Pichini S, Navarro M, Pacifici R, et al. Usefulness of sweat testing for the detection of MDMA after a single-dose administration. J Anal Toxicol. 2003;27:294-303.
12. Pacifici R, Farré M, Pichini S, et al. Sweat testing of MDMA with the Drugwipe analytical device: a controlled study with two volunteers. J Anal Toxicol. 2001;25:144-146.
13. Barnes AJ, De Martinis BS, Gorelick DA, et al. Disposition of MDMA and metabolites in human sweat following controlled MDMA administration. Clin Chem. 2009;55:454-462.
14. Barnes AJ, Smith ML, Kacinko SL, et al. Excretion of methamphetamine and amphetamine in human sweat following controlled oral metham-phetamine administration. Clin Chem. 2008;54:172-180.
15. Wang Y, Moss J, Thisted R. Predictors of body surface area. J Clin Anesth. 1992;4:4-10.
16. Marchei E, Farrè M, Pellegrini M, et al. Liquid chromatography-electrospray ionization mass spectrometry determination of methylphe-nidate and ritalinic acid in conventional and non-conventional biological matrices. J Pharm Biomed Anal. 2009;49:434-439.
17. Burns M, Baselt RC. Monitoring drug use with a sweat patch: an experiment with cocaine. J Anal Toxicol. 1995;19:41-48.
18. Kintz P, Tracqui A, Jamey C, et al. Detection of codeine and phenobarbital in sweat collected with a sweat patch. J Anal Toxicol. 1996;20:197-201.