Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-γ activation in mice with chronic cerebral hypoperfusion

Stroke

Volumn 41, Issue 8, 2010, Pages 1798-1806

  Washida, Kazuo ^a   Ihara, Masafumi ^a   Nishio, Keiko ^a   Fujita, Youshi ^a   Maki, Takakuni ^a   Yamada, Mahito ^a   Takahashi, Jun ^c   Wu, Xiaofeng ^a   Kihara, Takeshi ^a   Ito, Hidefumi ^a   Tomimoto, Hidekazu ^b   Takahashi, Ryosuke ^a  

^a KYOTO UNIVERSITY   (Japan)

^b MIE UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

chronic cerebral hypoperfusion; oligovascular niche; oxidative stress; PPAR ; telmisartan

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CYTOKINE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TELMISARTAN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN PERFUSION; CAROTID ARTERY OBSTRUCTION; CELL LOSS; COGNITIVE DEFECT; COMMON CAROTID ARTERY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG MEGADOSE; GLIA CELL; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MALE; MAZE TEST; MOUSE; MULTIINFARCT DEMENTIA; NONHUMAN; OLIGODENDROGLIA; OXIDATIVE STRESS; PRIORITY JOURNAL; SPATIAL MEMORY; SYSTOLIC BLOOD PRESSURE; VASCULAR ENDOTHELIUM; WORKING MEMORY;

ANALYSIS OF VARIANCE; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANILIDES; ANIMALS; BENZIMIDAZOLES; BENZOATES; CAROTID ARTERY, COMMON; CAROTID STENOSIS; CEREBRAL CORTEX; CHEMOKINE CCL2; COGNITION; COGNITION DISORDERS; IMMUNOHISTOCHEMISTRY; MALE; MEMORY, SHORT-TERM; MICE; MICE, INBRED C57BL; OLIGODENDROGLIA; OXIDATIVE STRESS; PPAR GAMMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPATIAL BEHAVIOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955171963     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.583948     Document Type: Article

References (16)

1. Tzourio C, Anderson C, Chapman N, Woodward M, Neal B, MacMahon S, Chalmers J; PROGRESS Collaborative Group. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med. 2003;163:1069-1075.
2. Saxby BK, Harrington F, Wesnes KA, McKeith IG, Ford GA. Cande-sartan and cognitive decline in older patients with hypertension: a substudy of the SCOPE trial. Neurology. 2008;70:1858-1866.
3. Li NC, Lee A, Whitmer RA, Kivipelto M, Lawler E, Kazis LE, Wolozin B. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ. 2010;340:b5465.
4. Diener HC, Sacco RL, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlof B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, VanderMaelen C, Voigt T, Weber M, Yoon BW; Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Stroke (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol. 2008;7:875-884.
5. Benson SC, Pershadsingh HA, Ho CI, Chittiboyina A, Desai P, Pravenec M, Qi N, Wang J, Avery MA, Kurtz TW. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARy-modulating activity. Hypertension. 2004;43:993-1002.
6. Tsukuda K, Mogi M, Iwanami J, Min LJ, Sakata A, Jing F, Iwai M, Horiuchi M. Cognitive deficit in amyloid-/3-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator- activated receptor-y activation. Hypertension. 2009; 54:782-787.
7. Shibata M, Ohtani R, Ihara M, Tomimoto H. White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion. Stroke. 2004;35:2598-2603.
8. Shibata M, Yamasaki N, Miyakawa T, Kalaria RN, Fujita Y, Ohtani R, Ihara M, Takahashi R, Tomimoto H. Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion. Stroke. 2007;38:2826-2832.
9. Nakano A, Hattori Y, Aoki C, Jojima T, Kasai K. Telmisartan inhibits cytokine-induced nuclear factor-KB activation independently of the peroxisome proliferator-activated receptor-y. Hypertens Res. 2009;32: 765-769.
10. Matsui T, Yamagishi S, Ueda S, Nakamura K, Imaizumi T, Takeuchi M, Inoue H. Telmisartan, an angiotensin II type 1 receptor blocker, inhibits advanced glycation end-product (AGE)-induced monocyte chemoat-tractant protein-1 expression in mesangial cells through downregulation of receptor for AGEs via peroxisome proliferator-activated receptor-7 activation. J Int Med Res. 2007;35:482-489.
11. Walther T, Olah L, Harms C, Maul B, Bader M, Hortnagl H, Schultheiss HP, Mies G. Ischemic injury in experimental stroke depends on angiotensin II. FASEB J. 2002;16:169-176.
12. Takizawa S, Dan T, Uesugi T, Nagata E, Takagi S, van Ypersele de Strihou C, Miyata T. A sartan derivative with a very low angiotensin II receptor affinity ameliorates ischemic cerebral damage. J Cereb Blood Flow Metab. 2009;29:1665-1672.
13. Schrader J, Lüders S, Kulschewski A, Berger J, Zidek W, Treib J, Einhaupl K, Diener HC, Dominiak P; Acute Candesartan Cilexetil Therapy in Stroke Survivors Study Group. The ACCESS Study: evaluation of acute candesartan cilexetil therapy in stroke survivors. Stroke. 2003;34:1699-1703.
14. Sarti C, Pantoni L, Bartolini L, Inzitari D. Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat. Behav Brain Res. 2002;136:13-20.
15. Nishio K, Ihara M, Yamasaki N, Kalaria RN, Maki T, Fujita Y, Ito H, Oishi N, Fukuyama H, Miyakawa T, Takahashi R, Tomimoto H. A mouse model characterizing features of vascular dementia with hippocampal atrophy. Stroke. 2010;41:1278-1284.
16. Arai K, Lo EH. An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci. 2009;29:4351-4355.