A third allele of the HPA-5 (Br) platelet alloantigen system identified in investigating a case of neonatal thrombocytopenia

Transfusion

Volumn 50, Issue 8, 2010, Pages 1855-1856

  Peterson, Julie A ^a   Gitter, Maria L ^a   Pietz, Bradley ^a   Bellissimo, Daniel ^a   Curtis, Brian ^a   Aster, Richard ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; MATERNAL ANTIBODY; THROMBOCYTE ANTIGEN; THROMBOCYTE ANTIGEN HPA 5; UNCLASSIFIED DRUG; 5A ALLOANTIGEN, HUMAN; 5B ALLOANTIGEN, HUMAN;

ALLELE; AMINO ACID SUBSTITUTION; CASE REPORT; DNA FINGERPRINTING; DOWN SYNDROME; GENE MUTATION; GENOTYPE; HUMAN; INFANT; LETTER; MALE; NEONATAL THROMBOCYTOPENIA; NUCLEOTIDE SEQUENCE; THROMBOCYTE COUNT; TRISOMY 21; GENETICS; NEONATAL ALLOIMMUNE THROMBOCYTOPENIA; NEWBORN;

ALLELES; ANTIGENS, HUMAN PLATELET; HUMANS; INFANT, NEWBORN; MALE; THROMBOCYTOPENIA, NEONATAL ALLOIMMUNE;

EID: 77955169211     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2010.02660.x     Document Type: Letter

References (5)

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2. Santoso S, Kalb R, Walka M, Kiefel V, Mueller-Eckhardt C, Newman PJ. The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2). J Clin Invest 1993 92 : 2427 32.
3. Kaplan C, Morel-Kopp MC, Kroll H, Kiefel V, Schlegel N, Chesnel N, Mueller-Eckhardt C. HPA-5b (Br(a)) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases. Br J Haematol 1991 78 : 425 9.
4. Curtis BR. Genotyping for human platelet alloantigen polymorphisms: applications in the diagnosis of alloimmune platelet disorders. Semin Thromb Hemost 2008 34 : 539 48.
5. Thuring W, Tonz O. [Neonatal thrombocyte values in children with Down's syndrome and other autosome trisomies]. Helv Paediatr Acta 1979 34 : 545 55.