Study of film forming properties of hydroxy propyl guar and its use in preparation of medicated transdermal patches

Indian Journal of Pharmaceutical Education and Research

Volumn 42, Issue 2, 2008, Pages 147-153

  Swamy, N G N ^a   Dharmarajan, T S ^a   Paranjothi, K L K ^a  

^a Government College of Pharmacy   (India)

Author keywords

Breaking force; Folding endurance; Hydroxypropyl guar; Moisture loss uptake; Permeation co efficient; Piercing load; Salbutamol sulphate medicated patches; Tensile strength

Indexed keywords

CARBOXYMETHYLCELLULOSE; EXCIPIENT; HYDROXYPROPYL GUAR; METHYL PARABEN; PLASTICIZER; PROPYLENE GLYCOL; SALBUTAMOL SULFATE; UNCLASSIFIED DRUG; WATER;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG DETERMINATION; DRUG DOSAGE FORM COMPARISON; DRUG RELEASE; DRY WEIGHT; FILM; FILM BREAKING FORCE; FILM FOLDING ENDURANCE; FILM PIERCING LOAD; FILM WEIGHT; GUAR; HAIRLESS RAT; HARDNESS; HUMIDITY; IN VITRO STUDY; MOISTURE; NONHUMAN; RAT; SKIN IRRITATION; SKIN PERMEABILITY; TEMPERATURE; TENSILE STRENGTH; THICKNESS; TRANSDERMAL PATCH; VISCOSITY; WATER LOSS; WATER PERMEABILITY;

EID: 77955153230     PISSN: 00195464     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Paranjothi KLK and Thampi P. Development of transdermal patches of Verapamil Hydrochloride using sodium carboxymethyl guar as a monolithic polymer matrix and their invitro release studies. Ind J Pharm Sci 1997; 59(2): 49-54.
2. Robert L Davidson. Handbook of water-soluble gums and resins. New York: Mc Graw Hill Book Company; 1980
3. Swamy NGN, Dharmarajan TS, Paranjothi KLK. Study of hydroxypropyl guar derivative for its gelling property and its use in the formulation of Tenoxicam gels. Pak J Pharm Sci 2007; 20(1): 61-66.
4. Swamy NGN, Dharmarajan TS, Paranjothi KLK. Study of thickening properties of hydroxypropyl guar and its utilization in the formulation and evaluation of Ibuprofen suppositories. Indian Drugs 2007; 44(12): 925-29
5. Goodman and Gilman. The Pharmacological basis of Therapeutics. 9th Edition. New York: Pergmon Press; 1990.
6. Swamy NGN, Dharmarajan TS, Paranjothi KLK. Derivatization of guar to various hydroxyalkyl derivatives; their purification and characterization. Indian Drugs 2006; 43(9): 756-59.
7. Lawrence R Jones, John A Riddick. Colorimetric estimation of Propane 1,2 - diol and related compounds. Anal Chem 1957; 29(8): 1214-16.
8. Ramarao P, Prakash VD. Comparative in vivo evaluation of diltiazem hydrochloride following oral and transdermal administration in rabbits. Ind J Pharmacol 1999; 31: 294-98.
9. Ubaidulla U, Molugu VSR, Ruckmani K, Ahmad FJ, Khar RK. Transdermal Therapeutic System of Carvedilol: Effect of Hydrophilic and Hydrophobic Matrix on In Vitro and In Vivo Characteristics. AAPS Pharm Sci Tech 2007; 8(1): E1 - E8.
10. Lalla JK, Seethalaxmi KR, Dattani KK. Nitroglycerin controlled release transdermal patch. Indian Drugs 1989; 26(6): 284-94.
11. Seth AK, Agarwal GP, Saini TR. Evaluation of free films. Indian Drugs 1985; 22(1): 45-47.
12. Swamy NGN. Synthesis, purification and characterization of hydroxyalkyl derivatives of guar and study of pharmaceutical applications of select guar derivative [PhD dissertation]. Bangalore Univ.; 2002.
13. Singbal DM, Joshi SV. Spectrocolorimetric estimation of salbutamol sulphate and its pharmaceutical formulations. Indian Drugs 1984; 21(6): 398-91.
14. Malathi RB, Deshpande SG, Singh PK et al. Studies on polymeric films for transdermal use. Ind J Pharm Sci 1988; 50(3): 153-56.
15. Bhalla HL, Gadkari SJ. Transdermal films of Isosorbide dinitrate. Indian Drugs 1987; 24(6): 313-15.