Clozapine is cytotoxic to primary cultures of human bone marrow mesenchymal stromal cells

Journal of Clinical Psychopharmacology

Volumn 30, Issue 4, 2010, Pages 461-463

  Lahdelma, Liisa ^a   Oja, Sofia ^b   Korhonen, Matti ^c   Andersson, Leif C ^a,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; NEUROLEPTIC AGENT;

AGRANULOCYTOSIS; BLOOD CELL; BONE MARROW; CELL CULTURE; CELL DEATH; CELL DIFFERENTIATION; HEMATOPOIESIS; HEMATOPOIETIC CELL; HUMAN; LETTER; MESENCHYME CELL; OXIDATION; PRIORITY JOURNAL; STEM CELL; STROMA CELL; ADULT; AGED; BONE MARROW CELL; CHEMICALLY INDUCED; DRUG EFFECTS; FIBROBLAST; MALE; MESENCHYMAL STROMA CELL; METABOLISM; TOXICITY; YOUNG ADULT;

ADULT; AGED; AGRANULOCYTOSIS; ANTIPSYCHOTIC AGENTS; BONE MARROW CELLS; CELLS, CULTURED; CLOZAPINE; FIBROBLASTS; HUMANS; MALE; MESENCHYMAL STROMAL CELLS; YOUNG ADULT;

EID: 77955144515     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3181e6a082     Document Type: Letter

References (10)

1. Williams DP, Pirmohamed M, Naisbitt DJ, et al. Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis. J Pharmacol Exp Ther. 1997;283: 1375-1382.
2. Williams DP, Pirmohamed M, Naisbitt DJ, et al. Induction of metabolism-dependent and-independent neutrophil apoptosis by clozapine. Mol Pharmacol. 2000;58: 207-216.
3. Gardner I, Popovic M, Zahid N, et al. A comparison of the covalent binding of clozapine, procainamide, and vesnarinone to human neutrophils in vitro and rat tissues in vitro and in vivo. Chem Res Toxicol. 2005;18:1384-1394.
4. Pereira A, Dean B. Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: a potential in vitro system for the study of agranulocytosis. Biochem Pharmacol. 2006;72:783-793.
5. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143-147.
6. Guest I, Uetrecht J. Drugs that induce neutropenia/agranulocytosis may target specific components of the stromal cell extracellular matrix. Med Hypotheses. 1999;53:145-151.
7. Mandelin J, Hukkanen M, Li TF, et al. Human osteoblasts produce cathepsin K. Bone. 2006;38:769-777.
8. Flanagan RJ, Dunk L. Haematological toxicity of drugs used in psychiatry. Hum Psychopharmacol. 2008;23(suppl 1):27-41.
9. Uetrecht JP. Reactive metabolites and agranulocytosis. Eur J Haematol Suppl. 1996;60:83-88.
10. Bergemann N, Abu-Tair F, Aderjan R, et al. High clozapine concentrations in leukocytes in a patient who developed leukocytopenia. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:1068-1071.