Changes in collagen with aging maintain molecular stability after overload: Evidence from an in vitro tendon model

Journal of Biomechanical Engineering

Volumn 132, Issue 3, 2010, Pages

  Willett, Thomas L ^a   Labow, Rosalind S ^b   Aldous, Ian G ^c   Avery, Nick C ^d   Lee, J Michael ^c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^c DALHOUSIE UNIVERSITY   (Canada)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Age; Collagen; Crosslinking; Injury; Mechanical damage; Molecular stability

Indexed keywords

BASELINE DATA; COLLAGEN CROSSLINKING; COLLAGEN STABILITY; COLLAGENOUS FIBERS; COMPOSITIONAL CHANGES; COMPOSITIONAL DIFFERENCE; CONCENTRATION OF; COVALENT CROSS-LINKS; COVALENT CROSSLINKING; CROSSLINKS; IN-VITRO; ION EXCHANGE CHROMATOGRAPHY; ISOMETRIC TENSION; LOSS OF STABILITY; MECHANICAL DAMAGES; MOLECULAR LEVELS; MOLECULAR STABILITY; SOFT-TISSUE INJURY; THERMAL DENATURATIONS; THERMAL STABILITY; THERMALLY STABLE; THERMO-MECHANICAL; TISSUE STRENGTH;

CHEMICAL DETECTION; CHROMATOGRAPHIC ANALYSIS; DAMAGE DETECTION; DIFFERENTIAL SCANNING CALORIMETRY; ION CHROMATOGRAPHY; ION EXCHANGE; MECHANICS; PYROLYSIS; TENDONS; THERMODYNAMIC STABILITY;

COLLAGEN;

COLLAGEN;

AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DENATURATION; DIFFERENTIAL SCANNING CALORIMETRY; IN VITRO STUDY; ION EXCHANGE CHROMATOGRAPHY; ISOMETRICS; MOLECULAR STABILITY; MUSCLE TONE; NONHUMAN; TAIL; TENDON; THERMOSTABILITY; ANIMAL; BIOLOGICAL MODEL; CATTLE; CHEMISTRY; COMPUTER SIMULATION; HUMAN; MECHANICAL STRESS; MECHANOTRANSDUCTION; PHYSIOLOGY; ULTRASTRUCTURE; WEIGHT BEARING;

ANIMALIA; BOS; BOVINAE;

AGING; ANIMALS; CATTLE; COLLAGEN; COMPUTER SIMULATION; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MODELS, BIOLOGICAL; STRESS, MECHANICAL; TENDONS; WEIGHT-BEARING;

EID: 77955110336     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4000933     Document Type: Article

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