Experimental techniques for studying poroelasticity in brain phantom gels under high flow microinfusion

Journal of Biomechanical Engineering

Volumn 132, Issue 5, 2010, Pages

  Ivanchenko, O ^a   Sindhwani, N ^a   Linninger, A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Fluid structure interaction; Invasive drug delivery; Microinfusion; Porosity change; Porous tissue deformation

Indexed keywords

INVASIVE DRUG DELIVERY; MICROINFUSION; POROSITY CHANGES; POROUS TISSUE; POROUS TISSUE DEFORMATION;

CATHETERS; DEFORMATION; DRUG DELIVERY; DRUG INTERACTIONS; FLUID STRUCTURE INTERACTION; FLUIDS; GELS; HYDRAULIC CONDUCTIVITY; LEAKAGE (FLUID); MATRIX ALGEBRA; POROSITY; POROUS MATERIALS; WATER WAVE EFFECTS;

FLOW OF FLUIDS;

NANOBEAD;

ARTICLE; CATHETER; COMPUTER MODEL; ELASTICITY; FLUID FLOW; GEL; HYDRAULIC CONDUCTIVITY; INFUSION; MECHANICAL STRESS; PHANTOM; POROSITY; VELOCITY; ALZHEIMER DISEASE; BODY FLUID; BRAIN; IMAGE QUALITY; PHYSICAL PHENOMENA; PHYSIOLOGY; RESEARCH;

ALZHEIMER DISEASE; BODY FLUIDS; BRAIN; GELS; PHANTOMS, IMAGING; PHYSICAL PROCESSES; POROSITY; RESEARCH;

EID: 77955099101     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4001164     Document Type: Article

References (23)

1. Hall, W. A., Rustamzadeh, E., and Asher, A. L., 2003, "Convection-Enhanced Delivery in Clinical Trials," Neurosurg. Focus, 14(2), pp. 1-4.
2. Kunwar, S., 2003, "Convection Enhanced Delivery of Il13-Pe38 qqr for Treatment of Recurrent Malignant Glioma: Presentation of Interim Findings From Ongoing Phase 1 Studies," Acta Neurochir. Suppl. (Wien), 88, pp. 105-111.
3. Bobo, R. H., Laske, D. W., Akbasak, A., Morrison, P. F., Dedrick, R. L., and Oldfield, E. H., 1994, "Convection-Enhanced Delivery of Macromolecules in the Brain," Proc. Natl. Acad. Sci. U.S.A., 91(6), pp. 2076-2080.
4. Gliadel Wafers, www.gliadel.com
5. Fleming, A. B., and Saltzman, W. M., 2002, "Pharmacokinetics of the Carmustine Implant," Clin. Pharmacokinet, 41, pp. 403-419.
6. Sampson, J. H., Brady, M. L., Petry, N. A., Croteau, D., Friedman, A. H., Friedman, H. S., Wong, T., Bigner, D. D., Pastan, I., Puri, R. K., and Pedain, C., 2007, "Intracerebral Infusate Distribution by Convection-Enhanced Delivery in Humans With Malignant Gliomas: Descriptive Effects of Target Anatomy and Catheter Positioning," Neurosurgery, 60(2), pp. 89-99.
7. Raghavan, R., Brady, M. L., Rodriguez-Ponce, M. I., Hartlep, A., Pedain, C., and Sampson, J. H., 2006, "Convection-Enhanced Delivery of Therapeutics for Brain Disease, and Its Optimization," Neurosurg. Focus, 20(4), pp. 1-13.
8. Morrison, P. F., Chen, M. Y., Chadwick, R. S., Lonser, R. R., and Oldfield, E. H., 1999, "Focal Delivery During Direct Infusion to Brain: Role of Flow Rate, Catheter Diameter, and Tissue Mechanics," Am. J. Physiol. Regulatory Integrative Comp. Physiol., 277(4), pp. R1218-1229.
9. Chen, Z.-J., Broaddus, W. C., Viswanathan, R. R., Raghavan, R., and Gillies, G. T., 2002, "Intraparenchymal Drug Delivery Via Positive-Pressure Infusion: Experimental and Modeling Studies of Poroelasticity in Brain Phantom Gels," IEEE Trans. Biomed. Eng., 49(2), pp. 85-96.
10. Chen, Z.-J., Gillies, G. T., Broaddus, W. C., Prabhu, S. S., Fillmore, H., Mitchell, R. M., Corwin, F. D., and Fatouros, P. P., 2004, "A Realistic Brain Tissue Phantom for Intraparenchymal Infusion Studies," J. Neurosurg., 101(2), pp. 314-322. (Pubitemid 38971010)
11. Linninger, A. A., Somayaji, M. R., Zhang, L., Hariharan, M. S., and Penn, R. D., 2008, "Rigorous Mathematical Modeling Techniques for Optimal Delivery of Macromolecules to the Brain," IEEE Trans. Biomed. Eng., 55(9), pp. 2303-2313.
12. Lynch, T. M., and Lintilhac, P. M., 1997, "Mechanical Signals in Plant Development: A New Method for Single Cell Studies," Dev. Biol., 181(2), pp. 246-256.
13. Dally, J. W., and Riley, W. F., 1991, Experimental Stress Analysis, McGraw-Hill, New York.
14. Gillies, G. T., Wilhelm, T. D., Humphrey, J. A. C., Fillmore, H. L., Holloway, K. L., and Broaddus, W. C., 2002, "A Spinal Cord Surrogate With Nanoscale Porosity for In Vitro Simulations of Restorative Neurosurgical Techniques," Nanotechnology, 13(5), pp. 587-591.
15. Raffel, M., Willert, C. E., Wereley, S. T., and Kompenhans, J., 1998, Particle Image Velocimetry: A Practical Guide, Springer, New York.
16. Innovative Scientific Solutions Inc., http://www.innssi.com/
17. MATLAB, R2008b, www.mathworks.com
18. Netti, P. A., Baxter, L. T., Boucher, Y., Skalak, R., and Jain, R. K., 1997, "Macro- and Microscopic Fluid Transport in Living Tissues: Application to Solid Tumors," AIChE J., 43(3), pp. 818-834. (Pubitemid 27205682)
19. Bowen, R. M., 1980, "Incompressible Porous Media Models by Use of the Theory of Mixtures," Eng. Sci., 18, pp. 1129-1148.
20. Schmid Scholbein, G. W., Woo, S. L.-Y., and Zweifach, B. W., 1986, Frontiers in Biomechanics, Springer-Verlag, New York.
21. Smith, J. H., and García, J. J., 2009, "A Nonlinear Biphasic Model of Flow-Controlled Infusion in Brain: Fluid Transport and Tissue Deformation Analyses," J. Biomech., 42(13), pp. 2017-2025.
22. Bauman, M. A., Gillies, G. T., Raghavan, R., Brady, M. L., and Pedain, C., 2004, "Physical Characterization of Neurocatheter Performance in a Brain Phantom Gelatin With Nanoscale Porosity: Steady-State and Oscillatory Flows," Nanotechnology, 15(1), pp. 92-97.
23. Gu, W., Yao, H., Vega, A., and Flagler, D., 2004, "Diffusivity of Ions in Agarose Gels and Intervertebral Disc: Effect of Porosity," Ann. Biomed. Eng., 32(12), pp. 1710-1717.