Chronic partial bladder outlet obstruction does not impair erectile function in male rats

BJU International

Volumn 106, Issue 4, 2010, Pages 572-577

  Aldridge, Nicholas ^a   Kim, Hyun Woo ^b   Motamedi, Amir ^a   Rajasekaran, Mahadevan ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b The Catholic University of Korea   (South Korea)

Author keywords

bladder outlet obstruction; erectile function; rats; Rho A

Indexed keywords

1,1 DIETHYL 2 HYDROXY 2 NITROSO HYDRAZINE; 3,3 BIS(2 AMINOETHYL) 1 HYDROXY 2 OXOTRIAZENE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; HYDRAZINE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLADDER OBSTRUCTION; CHRONIC PARTIAL BLADDER OUTLET OBSTRUCTION; CONTROLLED STUDY; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; IMMUNOREACTIVITY; LIGATION; MALE; MICTURITION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; COMPLICATION; IMPOTENCE, VASCULOGENIC; METABOLISM; PATHOPHYSIOLOGY; PENIS ERECTION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; IMPOTENCE, VASCULOGENIC; MALE; PENILE ERECTION; RATS; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; URINARY BLADDER NECK OBSTRUCTION;

EID: 77955081452     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2009.09105.x     Document Type: Article

References (25)

1. Selvin E, Burnett AL, Platz EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med 2007 120 : 151 157
2. Rosen R, Altwein J, Boyle P et al. Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7). Eur Urol 2003 44 : 637 649
3. McVary KT. Erectile dysfunction and lower urinary tract symptoms secondary to BPH. Eur Urol 2005 47 : 838 845
4. Braun MH, Sommer F, Haupt G, Mathers MJ, Reifenrath B, Engelmann UH. Lower urinary tract symptoms and erectile dysfunction: co-morbidity or typical 'Aging Male' symptoms? Results of the 'Cologne Male Survey'. Eur Urol 2003 44 : 588 594
5. Rosen RC. Update on the relationship between sexual dysfunction and lower urinary tract symptoms/benign prostatic hyperplasia. Curr Opin Urol 2006 16 : 11 9
6. McVary KT, McKenna KE. The relationship between erectile dysfunction and lower urinary tract symptoms: epidemiological, clinical, and basic science evidence. Curr Urol Rep 2004 5 : 251 257
7. McVary KT, Rademaker A, Lloyd GL, Gann P. Autonomic nervous system overactivity in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol 2005 174 : 1327 1433
8. McVary K. Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology. BJU Int 2006 97 (Suppl. 2 23 8 (Pubitemid 43356992)
9. Rajasekaran M, Wilkes N, Kuntz S, MEA. Rho-kinase inhibition suppresses bladder hyperactivity in spontaneously hypertensive rats. Neurourol Urodyn 2005 24 : 295 300
10. Wilkes N, White S, Stein P, Bernie J, Rajasekaran M. Phosphodiesterase-5 inhibition synergizes rho-kinase antagonism and enhances erectile response in male hypertensive rats. Int J Impot Res 2004 16 : 187 194
11. Mehta N, Sikka S, Rajasekaran M. Rat as an animal model for male erectile function evaluation in sexual medicine research. J Sex Med 2008 5 : 1278 1283
12. Rajasekaran M, Kasyan A, Jain A, Kim SW, Monga M. Altered growth factor expression in the aging penis: the Brown-Norway rat model. J Androl 2002 23 : 393 399
13. Jin L, Liu T, Lagoda GA, Champion HC, Bivalacqua TJ, Burnett AL. Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction. FASEB J 2006 20 : 536 538
14. Kim JC, Kim DB, Seo SI, Park YH, Hwang TK. Nerve growth factor and vanilloid receptor expression, and detrusor instability, after relieving bladder outlet obstruction in rats. BJU Int 2004 94 : 915 918
15. Chang S, Hypolite JA, Zderic SA, Wein AJ, Chacko S, DiSanto ME. Enhanced force generation by corpus cavernosum smooth muscle in rabbits with partial bladder outlet obstruction. J Urol 2002 167 : 2636 2644
16. Giuliano F, Allard J, Rampin O et al. Pro-erectile effect of systemic apomorphine: existence of a spinal site of action. J Urol 2002 167 : 402 406
17. Kim JC, Yoo JS, Park EY, Hong SH, Seo SI, Hwang TK. Muscarinic and purinergic receptor expression in the urothelium of rats with detrusor overactivity induced by bladder outlet obstruction. BJU Int 2008 101 : 371 375
18. Kim HS, Kim JC, Choo MS. Effects of nitric oxide synthases on detrusor overactivity after removal of bladder outlet obstruction in rats. Urol Int 2008 81 : 107 112
19. Bing W, Chang S, Hypolite JA et al. Obstruction-induced changes in urinary bladder smooth muscle contractility: a role for Rho kinase. Am J Physiol Renal Physiol 2003 285 : F990 7
20. Champion HC, Bivalacqua TJ, Takimoto E, Kass DA, Burnett AL. Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism. Proc Natl Acad Sci USA 2005 102 : 1661 1666
21. Champion HC, Bivalacqua TJ, Wang R et al. Induction of penile erection by intracavernosal and transurethral administration of novel nitric oxide donors in the cat. J Urol 1999 161 : 2013 2019
22. Bivalacqua TJ, Usta MF, Kendirci M et al. Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy. J Sex Med 2005 2 : 187 197
23. Chitaley K, Webb RC, Mills TM. Rho-kinase as a potential target for the treatment of erectile dysfunction. Drug News Perspect 2001 14 : 601 606
24. Rahman NU, Phonsombat S, Bochinski D, Carrion RE, Nunes L, Lue TF. An animal model to study lower urinary tract symptoms and erectile dysfunction: the hyperlipidaemic rat. BJU Int 2007 100 : 658 663
25. Christ GJ, Hsieh Y, Zhao W et al. Effects of streptozotocin-induced diabetes on bladder and erectile (dys) function in the same rat in vivo. BJU Int 2006 97 : 1076 1082