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Volumn 59, Issue SUPPL. 2, 2010, Pages
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Lead identification and optimization of diaminopyrimidines as histamine H4 receptor ligands
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Author keywords
Aminopyrimidine; Histamine H4 receptor; Inflammation; Purine; Structure affinity efficacyrelationships
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Indexed keywords
1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE;
AMINOPYRIMIDINE;
DIAMINOPYRIMIDINE DERIVATIVE;
GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT;
HISTAMINE AGONIST;
HISTAMINE H4 RECEPTOR;
HISTAMINE H4 RECEPTOR AGONIST;
HISTAMINE H4 RECEPTOR ANTAGONIST;
INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN;
PYRIMIDINE DERIVATIVE;
PYRIMIDINES AND PYRIMIDINE DERIVATIVES;
THIENOPYRIMIDINE;
TRIAZOLE;
TRIAZOLOPYRIMIDINE;
UNCLASSIFIED DRUG;
ANTIHISTAMINIC AGENT;
G PROTEIN COUPLED RECEPTOR;
GUANINE NUCLEOTIDE BINDING PROTEIN;
GUANOSINE 5' O (3 THIOTRIPHOSPHATE);
HISTAMINE RECEPTOR;
HRH4 PROTEIN, HUMAN;
LIGAND;
ARTICLE;
BINDING ASSAY;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG DETERMINATION;
DRUG EFFICACY;
DRUG MECHANISM;
DRUG POTENCY;
DRUG RECEPTOR BINDING;
DRUG RESEARCH;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
LIGAND BINDING;
PHARMACOLOGICAL STIMULATION;
PROTEIN EXPRESSION;
PROTEIN MODIFICATION;
REACTION OPTIMIZATION;
RECEPTOR AFFINITY;
RECEPTOR BLOCKING;
STRUCTURE ACTIVITY RELATION;
VIRTUAL REALITY;
CELL LINE;
CHEMISTRY;
COMPUTER SIMULATION;
DRUG EFFECT;
FACTUAL DATABASE;
HUMAN;
METABOLISM;
SYNTHESIS;
CELL LINE;
COMPUTER SIMULATION;
DATABASES, FACTUAL;
DRUG DESIGN;
DRUG EVALUATION, PRECLINICAL;
GTP-BINDING PROTEINS;
GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE);
HISTAMINE ANTAGONISTS;
HUMANS;
LIGANDS;
PYRIMIDINES;
RECEPTORS, G-PROTEIN-COUPLED;
RECEPTORS, HISTAMINE;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 77955069757
PISSN: 10233830
EISSN: 1420908X
Source Type: Journal
DOI: 10.1007/s00011-009-0143-2 Document Type: Article |
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Times cited : (12)
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References (7)
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