NDRG2 suppresses the proliferation of clear cell renal cell carcinoma cell A-498

Journal of Experimental and Clinical Cancer Research

Volumn 29, Issue 1, 2010, Pages

  Ma, Jian Jun ^a   Liao, Cheng Gong ^b   Jiang, Xue ^a   Zhao, Hua Dong ^a   Yao, Li Bo ^b   Bao, Ting Yi ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN DEPENDENT KINASE 2; CYCLIN E; N MYC DOWNSTREAM REGULATED GENE 2 PROTEIN; NITROBLUE TETRAZOLIUM; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; MESSENGER RNA; NDRG2 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER CELL A 498; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL LINE; CELL PROLIFERATION; CELL SORTER; CELL SURVIVAL; CLEAR CELL RENAL CELL CARCINOMA; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; KIDNEY CARCINOMA; PRIORITY JOURNAL; RECOMBINANT ADENOVIRUS PLASMID; RECOMBINANT PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; UPREGULATION; VIRUS RECOMBINANT; WESTERN BLOTTING; ADENOVIRUS; DRUG EFFECT; GENETICS; KIDNEY TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL CULTURE;

ADENOVIRIDAE; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, RENAL CELL; CELL PROLIFERATION; FLOW CYTOMETRY; G1 PHASE; HUMANS; KIDNEY NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 77955064120     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-29-103     Document Type: Article

References (18)

1. Cancer statistics, 2007. A Jemal R Siegel E Ward T Murray J Xu MJ Thun, CA Cancer J Clin 2007 57 43 66 10.3322/canjclin.57.1.43 17237035
2. Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene. S Boulkroun M Fay MC Zennaro B Escoubet F Jaisser M Blot-Chabaud N Farman N Courtois-Coutry, J Biol Chem 2002 277 31506 31515 10.1074/jbc.M200272200 12072429
3. N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. Y Deng L Yao L Chau SS Ng Y Peng X Liu WS Au J Wang F Li S Ji, et al. Int J Cancer 2003 106 342 347 10.1002/ijc.11228 12845671 (Pubitemid 36870394)
4. Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. X Qu Y Zhai H Wei C Zhang G Xing Y Yu F He, Mol Cell Biochem 2002 229 35 44 10.1023/A:1017934810825 11936845
5. NDRG2: a novel Alzheimer's disease associated protein. C Mitchelmore S Buchmann-Moller L Rask MJ West JC Troncoso NA Jensen, Neurobiol Dis 2004 16 48 58 10.1016/j.nbd.2004.01.003 15207261
6. Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. SC Choi KD Kim JT Kim JW Kim DY Yoon YK Choe YS Chang SG Paik JS Lim, FEBS Lett 2003 553 413 418 10.1016/S0014-5793(03)01030-5 14572661
7. Identification of novel tumour-associated genes differentially expressed in the process of squamous cell cancer development. L Hummerich R Muller J Hess F Kokocinski M Hahn G Furstenberger C Mauch P Lichter P Angel, Oncogene 2006 25 111 121 16247483
8. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. EA Lusis MA Watson MR Chicoine M Lyman P Roerig G Reifenberger DH Gutmann A Perry, Cancer Res 2005 65 7121 7126 10.1158/0008-5472.CAN-05-0043 16103061
9. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. HS Phillips S Kharbanda R Chen WF Forrest RH Soriano TD Wu A Misra JM Nigro H Colman L Soroceanu, et al. Cancer Cell 2006 9 157 173 10.1016/j.ccr.2006.02.019 16530701
10. Expression of NDRG2 in clear cell renal cell carcinoma. J Ma H Jin H Wang J Yuan T Bao X Jiang W Zhang H Zhao L Yao, Biol Pharm Bull 2008 31 1316 1320 10.1248/bpb.31.1316 18591767
11. Transcriptional targeted gene therapy for hepatocellular carcinoma by adenovirus vector. F Kanai, Mol Biotechnol 2001 18 243 250 10.1385/MB:18:3:243 11503518
12. Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues. XL Hu XP Liu YC Deng SX Lin L Wu J Zhang LF Wang XB Wang X Li L Shen, et al. Cell Tissue Res 2006 325 67 76 10.1007/s00441-005-0137-5 16520977
13. N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis. N Liu L Wang X Li Q Yang X Liu J Zhang Y Wu S Ji Y Zhang A Yang, et al. Nucleic Acids Res 2008 36 5335 5349 10.1093/nar/gkn504 18689861
14. NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. H Furuta Y Kondo S Nakahata M Hamasaki S Sakoda K Morishita, Biochem Biophys Res Commun 391 1785 1791 10.1016/j.bbrc.2009.12.156 20045673
15. NDRG2 suppresses cell proliferation through down-regulation of AP-1 activity in human colon carcinoma cells. YJ Kim SY Yoon JT Kim SC Choi JS Lim JH Kim EY Song HG Lee I Choi JW Kim, Int J Cancer 2009 124 7 15 10.1002/ijc.23945 18844221
16. Expression of NDRG2 is related to tumor progression and survival of gastric cancer patients through Fas-mediated cell death. SC Choi SR Yoon YP Park EY Song JW Kim WH Kim Y Yang JS Lim HG Lee, Exp Mol Med 2007 39 705 714 18160841
17. NDRG2 is a new HIF-1 target gene necessary for hypoxia-induced apoptosis in A549 cells. L Wang N Liu L Yao F Li J Zhang Y Deng J Liu S Ji A Yang H Han, et al. Cell Physiol Biochem 2008 21 239 250 10.1159/000113765 18209490
18. N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis. N Liu L Wang X Li Q Yang X Liu J Zhang J Zhang Y Wu S Ji Y Zhang, et al. Nucleic Acids Res 2008 36 5335 5349 10.1093/nar/gkn504 18689861