A gene-delivery system specific for hepatoma cells and an intracellular kinase signal based on human liver-specific bionanocapsules and signal-responsive artificial polymer

International Journal of Pharmaceutics

Volumn 396, Issue 1-2, 2010, Pages 174-178

  Oishi, Jun ^a,b   Jung, Joohee ^b,c   Tsuchiya, Akira ^a   Toita, Riki ^a   Kang, Jeong Hun ^a,b   Mori, Takeshi ^a   Niidome, Takuro ^a   Tanizawa, Katsuyuki ^b,c   Kuroda, Shun'ichi ^b,c   Katayama, Yoshiki ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Gene therapy; Hepatocellular carcinoma; Intracellular signal; Protein kinase; Tumor targeted gene delivery

Indexed keywords

BIONANOCAPSULE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; KEMPTIDE; LUCIFERASE; MACROGOL; NANOCAPSULE; POLY(N ISOPROPYLACRYLAMIDE); UNCLASSIFIED DRUG; ACRYLAMIDE DERIVATIVE; L PROTEIN, HEPATITIS B VIRUS; MACROGOL DERIVATIVE; N-ISOPROPYLACRYLAMIDE; OLIGOPEPTIDE; POLYMER; VIRUS ENVELOPE PROTEIN;

ARTICLE; CELL STRAIN HEPG2; COMPLEX FORMATION; DNA BINDING; ENZYME ACTIVITY; GEL ELECTROPHORESIS; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL; WESTERN BLOTTING; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYMOLOGY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE THERAPY; GENETICS; HEPG2 CELL LINE; LIVER NEOPLASMS; METABOLISM; PARTICLE SIZE; PROCEDURES; REPORTER GENE; SACCHAROMYCES CEREVISIAE;

ACRYLAMIDES; CARCINOMA, HEPATOCELLULAR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; GENES, REPORTER; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; NANOCAPSULES; OLIGOPEPTIDES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TRANSFECTION; VIRAL ENVELOPE PROTEINS; GENETIC THERAPY;

EID: 77955054321     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.06.012     Document Type: Article

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