Lower mRNA BDNF expression in lymphocytes: endophenotype or epiphenomenon for major depression?

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 34, Issue 6, 2010, Pages 1160-

  Brunoni, Andre Russowsky ^a   Cysneiros, Roberta Monterazzo ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b MACKENZIE PRESBYTERIAN UNIVERSITY   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOTROPIN RELEASING FACTOR; CORTISONE; HYDROCORTISONE; MESSENGER RNA;

GENE EXPRESSION; HORMONE BLOOD LEVEL; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; IMMUNE SYSTEM; LETTER; LYMPHOCYTE; MAJOR DEPRESSION; NERVOUS SYSTEM DEVELOPMENT; TRANSCRANIAL MAGNETIC STIMULATION; METABOLISM;

BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSIVE DISORDER, MAJOR; HUMANS; LYMPHOCYTES; RNA, MESSENGER;

EID: 77955050541     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2010.04.027     Document Type: Letter

References (10)

1. Bilbo S.D., Schwarz J.M. Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci 2009, 3:14.
2. Brunoni A.R., Lopes M., Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 2008, 11:1169-1180.
3. Ekdahl C.T., Claasen J.H., Bonde S., Kokaia Z., Lindvall O. Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci U S A 2003, 100:13632-13637.
4. Grippo A.J., Johnson A.K. Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models. Stress 2009, 12:1-21.
5. Hasler G., Drevets W.C., Manji H.K., Charney D.S. Discovering endophenotypes for major depression. Neuropsychopharmacology 2004, 29:1765-1781.
6. Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 2009, 71:171-186.
7. Lee B.H., Kim Y.K. BDNF mRNA expression of peripheral blood mononuclear cells was ecreased in depressive patients who had or had not recently attempted suicide. J Affect Disord 2010, [Epub ahead of print].
8. Pandey G.N., Dwivedi Y., Rizavi H.S., Ren X., Zhang H., Pavuluri M.N. Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects. Prog Neuropsychopharmacol Biol Psychiatry 2010, [Epub ahead of print].
9. Roman A., Rogoz Z., Kubera M., Nawrat D., Nalepa I. Concomitant administration of fluoxetine and amantadine modulates the activity of peritoneal macrophages of rats subjected to a forced swimming test. Pharmacol Rep 2009, 61:1069-1077.
10. Yulug B., Ozan E., Gonul A.S., Kilic E. Brain-derived neurotrophic factor, stress and depression: a minireview. Brain Res Bull 2009, 78:267-269.