Inactivation of formyltransferase (wbkC) gene generates a Brucella abortus rough strain that is attenuated in macrophages and in mice

Vaccine

Volumn 28, Issue 34, 2010, Pages 5627-5634

  Lacerda, Thaís Lourdes Santos ^a   Cardoso, Patrícia Gomes ^b   Augusto de Almeida, Leonardo ^a   Camargo, Ilana Lopes Baratella da Cunha ^c   Afonso, Daniela Almeida Freitas ^a   Trant, Cyntia Cardoso ^a   Macedo, Gilson Costa ^a   Campos, Eleonora ^d   Cravero, Silvio L ^d   Salcedo, Suzana P ^e,f,g   Gorvel, Jean Pierre ^e,f,g   Oliveira, Sérgio Costa ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF LAVRAS   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA INTA   (Argentina)

^e CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^f INSERM   (France)

^g CNRS   (France)

Author keywords

Brucella abortus; Live vaccine; Rough strain

Indexed keywords

BRUCELLA VACCINE; FORMYLTRANSFERASE; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; TRANSFERASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; LIVE VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BONE MARROW; BRUCELLA ABORTUS; BRUCELLOSIS; C57BL 6 MOUSE; CONTROLLED STUDY; DNA SEQUENCE; GENE DISRUPTION; IMMUNITY; IMMUNIZATION; IMMUNOFLUORESCENCE MICROSCOPY; KNOCKOUT MOUSE; LIPOGENESIS; MACROPHAGE; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; ANIMAL; BONE MARROW CELL; C57BL MOUSE; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MUTATION; PATHOGENICITY; VIRULENCE;

ANIMALS; BONE MARROW CELLS; BRUCELLA ABORTUS; BRUCELLA VACCINE; BRUCELLOSIS; HYDROXYMETHYL AND FORMYL TRANSFERASES; INTERLEUKIN-12; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, ATTENUATED; VIRULENCE;

EID: 77955049280     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.06.023     Document Type: Article

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