Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer

Familial Cancer

Volumn 9, Issue 2, 2010, Pages 125-129

  Ekstrand, Anna Isinger ^a   Jönsson, Mats ^a   Lindblom, Annika ^b   Borg, Åke ^a   Nilbert, Mef ^c  

^a LUND UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Hereditary nonpolyposis colorectal cancer (HNPCC); KRAS; Microsatellite instability; PI3K AKT mTOR; PTEN

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ADULT; AGED; ARTICLE; CANCER PATIENT; CHROMOSOME ABERRATION; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE SEQUENCE; HEREDITARY COLORECTAL CANCER; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADULT; AGED; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; FEMALE; GENE FREQUENCY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; METABOLIC NETWORKS AND PATHWAYS; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE;

MAMMALIA;

EID: 77955046859     PISSN: 13899600     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10689-009-9293-1     Document Type: Article

References (28)

1. Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2(7):489-501
2. Cantley LC, Neel BG (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96(8):4240-4245
3. Cantrell DA (2001) Phosphoinositide 3-kinase signalling pathways. J Cell Sci 114(Pt 8):1439-1445
4. Miyaki M, Iijima T, Yamaguchi T et al (2007) Mutations of the PIK3CA gene in hereditary colorectal cancers. Int J Cancer 121(7):1627-1630
5. Ollikainen M, Gylling A, Puputti M et al (2007) Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma. Int J Cancer 121(4):915-920
6. Samuels Y, Wang Z, Bardelli A et al (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304(5670):554 (Pubitemid 38541907)
7. Velho S, Oliveira C, Ferreira A et al (2005) The prevalence of PIK3CA mutations in gastric and colon cancer. Eur J Cancer 41(11):1649-1654
8. Sartore-Bianchi A, Martini M, Molinari F et al (2009) PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res 69(5):1851-1857
9. Jass JR (2007) Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 50(1):113-130
10. Allen BA, Terdiman JP (2003) Hereditary polyposis syndromes and hereditary non-polyposis colorectal cancer. Best Pract Res Clin Gastroenterol 17(2):237-258
11. Peltomaki P, Lothe RA, Aaltonen LA et al (1993) Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res 53(24):5853-5855
12. Peltomaki P, Vasen H (2004) Mutations associated with HNPCC predisposition-update of ICG-HNPCC/INSiGHT mutation database. Dis Markers 20(4-5):269-276
13. Vasen HF, Watson P, Mecklin JP et al (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC. Gastroenterology 116(6):1453-1456
14. Ogino S, Goel A (2008) Molecular classification and correlates in colorectal cancer. J Mol Diagn 10(1):13-27
15. Isinger A, Bhat M, Borg A et al (2006) CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum. BMC Cancer 6:64
16. Saal LH, Holm K, Maurer M et al (2005) PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 65(7):2554-2559
17. Kato S, Iida S, Higuchi T et al (2007) PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. Int J Cancer 121(8):1771-1778
18. Parsons DW, Wang TL, Samuels Y et al (2005) Colorectal cancer: mutations in a signalling pathway. Nature 436(7052):792
19. Oda K, Stokoe D, Taketani Y et al (2005) High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res 65(23):10669-10673
20. Yuan TL, Cantley LC (2008) PI3K pathway alterations in cancer: variations on a theme. Oncogene 27(41):5497-5510
21. Ikenoue T, Kanai F, Hikiba Y et al (2005) Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res 65(11):4562-4567
22. Samuels Y, Diaz LA Jr, Schmidt-Kittler O et al (2005) Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 7(6):561-573
23. Fenic I, Steger K, Gruber C et al (2007) Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell carcinoma. Oncol Rep 18(1):253-259
24. Wang Y, Kristensen GB, Helland A et al (2005) Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas. Am J Clin Pathol 124(3):392-401
25. Bader AG, Kang S, Vogt PK (2006) Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci USA 103(5):1475-1479
26. Isakoff SJ, Engelman JA, Irie HY et al (2005) Breast cancerassociated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 65(23):10992-11000
27. Zhao JJ, Liu Z, Wang L et al (2005) The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci USA 102(51):18443-18448
28. Nosho K, Kawasaki T, Ohnishi M et al (2008) PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. Neoplasia 10(6):534-541