Diagnostic modalities in sarcoidosis: BAL, EBUS, and PET

Seminars in Respiratory and Critical Care Medicine

Volumn 31, Issue 4, 2010, Pages 404-408

  Costabel, Ulrich ^a   Bonella, Francesco ^a   Ohshimo, Shinichiro ^a   Guzman, Josune ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Bronchoalveolar lavage (BAL); diagnosis; endobronchial ultrasound guided transbronchial needle aspiration (EBUS TBNA); positron emission tomography (PET); sarcoidosis

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CONTRAST MEDIUM; FLUORODEOXYGLUCOSE F 18; LEVO 3 FLUORO ALPHA METHYLTYROSINE F 18; UNCLASSIFIED DRUG;

ENDOBRONCHIAL ULTRASONOGRAPHY; ENDOBRONCHIAL ULTRASONOGRAPHY GUIDED TRANSBRONCHIAL NEEDLE ASPIRATION; HUMAN; LUNG LAVAGE; LUNG SARCOIDOSIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; TRANSBRONCHIAL ASPIRATION; CD4 CD8 RATIO; ENDOSCOPIC ECHOGRAPHY; NEEDLE BIOPSY; PATHOLOGY; PREDICTIVE VALUE; PROCEDURES; SARCOIDOSIS;

BIOPSY, NEEDLE; BRONCHOALVEOLAR LAVAGE; CD4-CD8 RATIO; HUMANS; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; SARCOIDOSIS; SENSITIVITY AND SPECIFICITY; ULTRASONOGRAPHY, INTERVENTIONAL;

EID: 77955020754     PISSN: 10693424     EISSN: 10989048     Source Type: Journal    
DOI: 10.1055/s-0030-1262207     Document Type: Review

References (52)

1. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 1999 160 736-755
2. Costabel U, Ohshimo S, Guzman J. Diagnosis of sarcoidosis. Curr Opin Pulm Med 2008 14 455-461
3. Costabel U, Guzman J. Bronchoalveolar lavage in interstitial lung disease. Curr Opin Pulm Med 2001 7 255-261
4. Reynolds H Y. Bronchoalveolar lavageobtaining biologic specimens from the respiratory tract surface. Sarcoidosis Vasc Diffuse Lung Dis 2008 25 5-9
5. Costabel U, Guzman J, Drent M. Diagnostic approach to sarcoidosis. Eur Respir Mon 2005 32 259-264
6. Drent M, Mansour K, Linssen C. Bronchoalveolar lavage in sarcoidosis. Semin Respir Crit Care Med 2007 28 486-495
7. Bjermer L, Rosenhall L, Angstrm T, Hllgren R. Predictive value of bronchoalveolar lavage cell analysis in sarcoidosis. Thorax 1988 43 284-288
8. Drent M, Jacobs J A., de Vries J, Lamers R J., Liem I H., Wouters E F. Does the cellular bronchoalveolar lavage fluid profile reflect the severity of sarcoidosis? Eur Respir J 1999 13 1338-1344
9. Ziegenhagen M W., Rothe M E., Schlaak M, Mller-Quernheim J. Bronchoalveolar and serological parameters reflecting the severity of sarcoidosis. Eur Respir J 2003 21 407-413
10. Takahashi T, Azuma A, Abe S, Kawanami O, Ohara K, Kudoh S. Significance of lymphocytosis in bronchoalveolar lavage in suspected ocular sarcoidosis. Eur Respir J 2001 18 515-521
11. Drent M, van Nierop M A., Gerritsen F A., Wouters E F., Mulder P G. A computer program using BALF-analysis results as a diagnostic tool in interstitial lung diseases. Am J Respir Crit Care Med 1996 153 736-741
12. Drent M, Jacobs J A., Cobben N A., Costabel U, Wouters E F., Mulder P G. Computer program supporting the diagnostic accuracy of cellular BALF analysis: a new release. Respir Med 2001 95 781-786
13. Kantrow S P., Meyer K C., Kidd P, Raghu G. The CD4/CD8 ratio in BAL fluid is highly variable in sarcoidosis. Eur Respir J 1997 10 2716-2721
14. Costabel U, Zaiss A, Wagner D J. et al. Value of bronchoalveolar lavage lymphocyte subpopulations for the diagnosis of sarcoidosis In: Grassi C, Rizzato G, Pozzi E Sarcoidosis and Other Granulomatous Disorders. Amsterdam Elsevier 1988 429-432
15. Winterbauer R H., Lammert J, Selland M, Wu R, Corley D, Springmeyer S C. Bronchoalveolar lavage cell populations in the diagnosis of sarcoidosis. Chest 1993 104 352-361
16. Thomeer M, Demedts M. Predicitive value of CD4/CD8 ratio in bronchoalveolar lavage in the diagnosis of sarcoidosis [abstract]. Sarcoidosis Vasc Diffuse Lung Dis 1997 14 (Suppl 1) 36
17. Korosec P, Rijavec M, Silar M, Kern I, Kosnik M, Osolnik K. Deficiency of pulmonary Valpha24 Vbeta11 natural killer T cells in corticosteroid-nave sarcoidosis patients. Respir Med 2010 104 571-577
18. Heron M, Slieker W A., Zanen P et al. Evaluation of CD103 as a cellular marker for the diagnosis of pulmonary sarcoidosis. Clin Immunol 2008 126 338-344
19. Welker L, Jrres R A., Costabel U, Magnussen H. Predictive value of BAL cell differentials in the diagnosis of interstitial lung diseases. Eur Respir J 2004 24 1000-1006
20. Barrera L, Mendoza F, Zuiga J et al. Functional diversity of T-cell subpopulations in subacute and chronic hypersensitivity pneumonitis. Am J Respir Crit Care Med 2008 177 44-55
21. Ye Q, Nakamura S, Sarria R, Costabel U, Guzman J. Interleukin 12, interleukin 18, and tumor necrosis factor alpha release by alveolar macrophages: acute and chronic hypersensitivity pneumonitis. Ann Allergy Asthma Immunol 2009 102 149-154
22. Meyer K C., Soergel P. Variation of bronchoalveolar lymphocyte phenotypes with age in the physiologically normal human lung. Thorax 1999 54 697-700
23. Gilman M J., Wang K P. Transbronchial lung biopsy in sarcoidosis: an approach to determine the optimal number of biopsies. Am Rev Respir Dis 1980 122 721-724
24. Koonitz C H., Joyner L R., Nelson R A. Transbronchial lung biopsy via the fiberoptic bronchoscope in sarcoidosis. Ann Intern Med 1976 85 64-66
25. Garwood S, Judson M A., Silvestri G, Hoda R, Fraig M, Doelken P. Endobronchial ultrasound for the diagnosis of pulmonary sarcoidosis. Chest 2007 132 1298-1304
26. Wong M, Yasufuku K, Nakajima T et al. Endobronchial ultrasound: new insight for the diagnosis of sarcoidosis. Eur Respir J 2007 29 1182-1186
27. Morales C F., Patefield A J., Strollo P J. Jr, Schenk D A. Flexible transbronchial needle aspiration in the diagnosis of sarcoidosis. Chest 1994 106 709-711
28. Trisolini R, Lazzari Agli L, Cancellieri A et al. Transbronchial needle aspiration improves the diagnostic yield of bronchoscopy in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2004 21 147-151
29. Annema J T., Rabe K F. State of the art lecture: EUS and EBUS in pulmonary medicine. Endoscopy 2006 38 (Suppl 1) S118-S122
30. Michael H, Ho S, Pollack B, Gupta M, Gress F. Diagnosis of intra-abdominal and mediastinal sarcoidosis with EUS-guided FNA. Gastrointest Endosc 2008 67 28-34
31. Annema J T., Veseli M, Rabe K F. Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of sarcoidosis. Eur Respir J 2005 25 405-409
32. Wildi S M., Judson M A., Fraig M et al. Is endosonography guided fine needle aspiration (EUS-FNA) for sarcoidosis as good as we think? Thorax 2004 59 794-799
33. Fritscher-Ravens A, Sriram P V., Topalidis T et al. Diagnosing sarcoidosis using endosonography-guided fine-needle aspiration. Chest 2000 118 928-935
34. Oki M, Saka H, Kitagawa C et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration is useful for diagnosing sarcoidosis. Respirology 2007 12 863-868 (Pubitemid 350045713)
35. Tremblay A, Stather D R., Maceachern P, Khalil M, Field S K. A randomized controlled trial of standard vs endobronchial ultrasonography-guided transbronchial needle aspiration in patients with suspected sarcoidosis. Chest 2009 136 340-346
36. Nakajima T, Yasufuku K, Kurosu K et al. The role of EBUS-TBNA for the diagnosis of sarcoidosiscomparisons with other bronchoscopic diagnostic modalities. Respir Med 2009 103 1796-1800
37. Varela-Lema L, Fernndez-Villar A, Ruano-Ravina A. Effectiveness and safety of endobronchial ultrasound-transbronchial needle aspiration: a systematic review. Eur Respir J 2009 33 1156-1164
38. Tournoy K G., Bolly A, Aerts J G. et al. The value of endoscopic ultrasound after bronchoscopy to diagnose thoracic sarcoidosis. Eur Respir J 2010 35 1329-1335
39. Nguyen B D. F-18 FDG PET imaging of disseminated sarcoidosis. Clin Nucl Med 2007 32 53-54
40. Nishiyama Y, Yamamoto Y, Fukunaga K et al. Comparative evaluation of 18F-FDG PET and 67Ga scintigraphy in patients with sarcoidosis. J Nucl Med 2006 47 1571-1576
41. Futamatsu H, Suzuki J, Adachi S et al. Utility of gallium-67 scintigraphy for evaluation of cardiac sarcoidosis with ventricular tachycardia. Int J Cardiovasc Imaging 2006 22 443-448
42. Braun J J., Kessler R, Constantinesco A, Imperiale A. 18F-FDG PET/CT in sarcoidosis management: review and report of 20 cases. Eur J Nucl Med Mol Imaging 2008 35 1537-1543
43. Teirstein A S., Machac J, Almeida O, Lu P, Padilla M L., Iannuzzi M C. Results of 188 whole-body fluorodeoxyglucose positron emission tomography scans in 137 patients with sarcoidosis. Chest 2007 132 1949-1953
44. Kaira K, Oriuchi N, Otani Y et al. Diagnostic usefulness of fluorine-18-alpha-methyltyrosine positron emission tomography in combination with 18F-fluorodeoxyglucose in sarcoidosis patients. Chest 2007 131 1019-1027
45. Ohira H, Tsujino I, Ishimaru S et al. Myocardial imaging with 18F-fluoro-2-deoxyglucose positron emission tomography and magnetic resonance imaging in sarcoidosis. Eur J Nucl Med Mol Imaging 2008 35 933-941
46. Dubey N, Miletich R S., Wasay M, Mechtler L L., Bakshi R. Role of fluorodeoxyglucose positron emission tomography in the diagnosis of neurosarcoidosis. J Neurol Sci 2002 205 77-81
47. Aide N, Benayoun M, Kerrou K, Khalil A, Cadranel J, Talbot J N. Impact of [18F]-fluorodeoxyglucose ([18F]-FDG) imaging in sarcoidosis: unsuspected neurosarcoidosis discovered by [18F]-FDG PET and early metabolic response to corticosteroid therapy. Br J Radiol 2007 80 e67-e71
48. Bolat S, Berding G, Dengler R, Stangel M, Trebst C. Fluorodeoxyglucose positron emission tomography (FDG-PET) is useful in the diagnosis of neurosarcoidosis. J Neurol Sci 2009 287 257-259
49. Kim S K., Im H J., Kim W, Kim T S., Hwangbo B, Kim H J. F-18 fluorodeoxyglucose and F-18 fluorothymidine positron emission tomography/computed tomography imaging in a case of neurosarcoidosis. Clin Nucl Med 2010 35 67-70
50. Shulman J P., Latkany P, Chin K J., Finger P T. Whole-body 18FDG PET-CT imaging of systemic sarcoidosis: ophthalmic oncology and uveitis. Ocul Immunol Inflamm 2009 17 95-100
51. Keijsers R GM, Verzijlbergen J F., van Diepen D M., van den Bosch J M., Grutters J C. 18F-FDG PET in sarcoidosis: an observational study in 12 patients treated with infliximab. Sarcoidosis Vasc Diffuse Lung Dis 2008 25 143-149
52. Keijsers R G., Grutters J C., van Velzen-Blad H et al. 18F-FDG PET patterns and BAL cell profiles in pulmonary sarcoidosis. Eur J Nucl Med Mol Imaging 2010 February 16 (Epub ahead of print)