Effects of dissolved oxygen on fungal morphology and process rheology during fed-batch processing of Ganoderma lucidum

Journal of Microbiology and Biotechnology

Volumn 20, Issue 4, 2010, Pages 844-851

  Fazenda, Mariana L ^a   Harvey, Linda M ^a   McNeil, Brian ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Clamp connection; Dissolved oxygen; EPS; Fed batch; Ganoderma lucidum; Rheology

Indexed keywords

DISSOLVED OXYGEN; POLYSACCHARIDE;

ARTICLE; BIOMASS PRODUCTION; BROTH DILUTION; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; FED BATCH CULTURE; FED BATCH FERMENTATION; FLOW KINETICS; FUNGAL BIOMASS; FUNGAL MORPHOLOGY; FUNGUS GROWTH; FUNGUS HYPHAE; GANODERMA LUCIDUM; GROWTH REGULATION; NONHUMAN; OXYGEN CONCENTRATION; OXYGEN TENSION; SHEAR STRESS; SUBMERGED FERMENTATION; VISCOSITY;

BIOMASS; BIOREACTORS; HISTOCYTOCHEMISTRY; INDUSTRIAL MICROBIOLOGY; KINETICS; MYCELIUM; OXYGEN; REISHI; RHEOLOGY;

BASIDIOMYCOTA; GANODERMA LUCIDUM;

EID: 77955007605     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.0911.11020     Document Type: Article

References (32)

1. Bao, X. F., X. S. Wang, Q. Dong, J. N. Fang, and X. Y. Li. 2002. Structural features of immunologically active polysaccharides from Ganoderma lucidum. Phytochemistry 59: 175-181.
2. Barnes, H. A., J. F. Hutton, and K. Walters. 1989. An Introduction to Rheology. Elsevier Science Publishing Company, New York.
3. Buchs, J. and B. Zoels. 2001. Evaluation of maximum to specific power consumption ratio in shaking bioreactors. J. Chem. Eng. Jpn 34: 647-653.
4. Carlile, M. J., S. C. Watkinson, and G. W. Gooday. 2001. The Fungi. Academic Press, London
5. Doran, P. M. 1995. Bioprocess Engineering Principles. Elsevier Science and Technology, U.S.A.
6. Fang, Q. H., Y. J. Tang, and J. J. Zhong. 2002. Significance of inoculation density control in production of polysaccharide and ganoderic acid by submerged culture of Ganoderma lucidum. Process Biochem. 37: 1375-1379.
7. Fazenda, M. L. 2009. Submerged culture fermentation of the basidiomycete fungus Ganoderma lucidum for biomass formation. PhD Thesis, Strathclyde University, Glasgow.
8. Fazenda, M. L., R. Seviour, B. McNeil, and L. M. Harvey. 2008. Submerged culture fermentation of higher fungi: The macrofungi. Adv. Appl. Microbiol. 63: 33-103.
9. Gehrig, I., H. J. Bart, T. Anke, and R. Germerdonk. 1998. Influence of morphology and rheology on the production characteristics of the basidiomycete Cyathus striatus. Biotechnol Bioeng 59: 525-533.
10. Hwang, H. J., S. W. Kim, C. P. Xu, J. W. Choi, and J. W. Yun. 2004. Morphological and rheological properties of the three different species of basidiomycetes Phellinus in submerged cultures. J. Appl. Microbiol. 96: 1296-1305.
11. Lee, B. C., J. T. Bae, H. B. Pyo, T. B. Choe, S. W. Kim, H. J. Hwang, and J. W. Yun. 2004. Submerged culture conditions for the production of mycelial biomass and exopolysaccharides by the edible Basidiomycete Grifola frondosa. Enzym. Microb. Technol. 35: 369-376.
12. Lee, K. M., S. Y. Lee, and H. Y. Lee. 1999. Bistage control of pH for improving exopolysaccharide production from mycelia of Ganoderma lucidum in an air-lift fermentor. J. Biosci. Bioeng. 88: 646-650.
13. Li, Z. J., V. Shukla, A. P. Fordyce, A. G. Pedersen, K. S. Wenger, and M. R. Marten. 2000. Fungal morphology and fragmentation behavior in a fed-batch Aspergillus oryzae fermentation at the production scale. Biotechnol. Bioeng. 70: 300-312.
14. Märkl, H., R. Bronnenmeier, and B. Wittek. 1991. The resistance of microorganisms to hydrodynamic stress. Int. Chem. Eng. 31: 185-197.
15. McNeil, B., D. R. Berry, L. R. Harvey, A. Grant, and S. White. 1998. Measurement of autolysis in submerged batch cultures of Penicillium chrysogenum. Biotechnol. Bioeng. 57: 297-305.
16. McNeil, B. and L. M. Harvey. 1993. Viscous fermentation products. Crit. Rev. Biotechnol. 13: 275-304.
17. Metzner, A. B. and R. E. Otto. 1957. Agitation of non-Newtonian fluids. Am. Inst. Chem. Eng. J. 3: 3-10.
18. Mishra, P., P. Srivastava, and S. Kundu. 2005. A comparative evaluation of oxygen mass transfer and broth viscosity using Cephalosporin-C production as a case strategy. World J. Microbiol. Biotechnol. 21: 525-530.
19. Olsvik, E. S. and B. Kristiansen. 1992. Influence of oxygen-tension, biomass concentration, and specific growth-rate on the rheological properties of a filamentous fermentation broth. Biotechnol. Bioeng. 40: 1293-1299.
20. Packer, H. L. and C. R. Thomas. 1990. Morphological measurements on filamentous microorganisms by fully automatic image analysis. Biotechnol. Bioeng. 35: 870-881.
21. Park, E. Y., Y. Koike, K. Higashiyama, S. Fujikawa, and M. Okabe. 1999. Effect of nitrogen source on mycelial morphology and arachidonic acid production in cultures of Mortierella alpina. J. Biosci. Bioeng. 88: 61-67.
22. Paterson, R. R. M. 2006. Ganoderma - A therapeutic fungal biofactory. Phytochemistry 67: 1985-2001.
23. Pollard, D. J., G. Hunt, T. K. Kirschner, and P. M. Salmon. 2002. Rheological characterization of a fungal fermentation for the production of pneumocandins. Bioprocess Biosyst. Eng. 24: 373-383.
24. Reyes, C., C. Pena, and E. Galindo. 2003. Reproducing shake flasks performance in stirred fermentors: Production of alginates by Azotobacter vinelandii. J. Biotechnol. 105: 189-198.
25. Sinha, J., J. T. Bae, J. P. Park, C. H. Song, and J. W. Yun. 2001. Effect of substrate concentration on broth rheology and fungal morphology during exo-biopolymer production by Paecilomyces japonica in a batch bioreactor. Enzym. Microb. Technol. 29: 392-399.
26. Stanbury, P. F. 1995. Principles of Fermentation Technology, 2nd Ed. Butterworth-Heinemann Publications, Oxford.
27. Tang, Y. J., L. W. Zhu, H. M. Li, and D. S. Li. 2007. Submerged culture of mushrooms in bioreactors - Challenges, current state-of-the-art, and future prospects. Food Technol. Biotechnol. 45: 221-229.
28. Wagner, R., D. A. Mitchell, G. L. Sassaki, and M.A.L.D. Amazonas. 2004. Links between morphology and physiology of Ganoderma lucidum in submerged culture for the production of exopolysaccharide. J. Biotechnol. 114: 153-164.
29. Wang, S. Y., M. L. Hsu, H. C. Hsu, C. H. Tzeng, S. S. Lee, M. S. Shiao, and C. K. Ho. 1997. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int. J. Cancer 70: 699-705.
30. Wongwicharn, A., B. McNeil, and L. M. Harvey. 1999. Effect of oxygen enrichment on morphology, growth, and heterologous protein production in chemostat cultures of Aspergillus niger B1-D. Biotechnol. Bioeng. 65: 416-424.
31. Yang, F. C. and C. B. Liau. 1998. The influence of environmental conditions on polysaccharide formation by Ganoderma lucidum in submerged cultures. Process Biochem. 33: 547-553.
32. Znidarsic, P. and A. Pavko. 2001. The morphology of filamentous fungi in submerged cultivations as a bioprocess parameter. Food Technol. Biotechnol. 39: 237-252.