Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency

Developmental Dynamics

Volumn 239, Issue 8, 2010, Pages 2161-2171

  Liu, Pu ^a,b   Johnson, Randy L ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Cornea; Lmx1b; Mouse; Neural crest; Trabecular meshwork

Indexed keywords

ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CORNEA OPACITY; EMBRYO; EMBRYO DEVELOPMENT; GENE DELETION; GENETIC TRANSCRIPTION; GENOTYPE; INTRAOCULAR PRESSURE; LETHALITY; LMX1B GENE; MOUSE; NONHUMAN; NULL ALLELE; PERINATAL CARE; PERINATAL PERIOD; PRIORITY JOURNAL; TRABECULAR MESHWORK;

ANIMALS; CORNEA; HOMEODOMAIN PROTEINS; INTRAOCULAR PRESSURE; LIM-HOMEODOMAIN PROTEINS; MESODERM; MICE; NEURAL CREST; TRABECULAR MESHWORK; TRANSCRIPTION FACTORS;

MURINAE;

EID: 77954998334     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22347     Document Type: Article

References (37)

1. Azar DT. 2006. Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc 104:264-302.
2. Beebe DC. 2008. Maintaining transparency: a review of the developmental physiology and pathophysiology of two avascular tissues. Semin Cell Dev Biol 19:125-133.
3. Beebe DC, Coats JM. 2000. The lens organizes the anterior segment: specification of neural crest cell differentiation in the avian eye. Dev Biol 220:424-431.
4. Breitman ML, Bryce DM, Giddens E, Clapoff S, Goring D, Tsui LC, Klintworth GK, Bernstein A. 1989. Analysis of lens cell fate and eye morphogenesis in transgenic mice ablated for cells of the lens lineage. Development 106:457-463. (Pubitemid 19195220)
5. Chang B, Smith RS, Peters M, Savinova OV, Hawes NL, Zabaleta A, Nusinowitz S, Martin JE, Davisson ML, Cepko CL, Hogan BL, John SW. 2001. Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. BMC Genet 2:18.
6. Chen H, Lun Y, Ovchinnikov D, Kokubo H, Oberg KC, Pepicelli CV, Gan L, Lee B, Johnson RL. 1998. Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat Genet 19:51-55.
7. Dai JX, Johnson RL, Ding YQ. 2009. Manifold functions of the Nail-Patella Syndrome gene Lmx1b in vertebrate development. Dev Growth Differ 51:241-250.
8. Danielian PS, Muccino D, Rowitch DH, Michael SK, McMahon AP. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 8:1323-1326. (Pubitemid 29006707)
9. Ding YQ, Marklund U, Yuan W, Yin J, Wegman L, Ericson J, Deneris E, Johnson RL, Chen ZF. 2003. Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci 6:933-938.
10. Dreyer SD, Zhou G, Baldini A, Winterpacht A, Zabel B, Cole W, Johnson RL, Lee B. 1998. Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome. Nat Genet 19:47-50.
11. Edelhauser HF. 2006. The balance between corneal transparency and edema: the Proctor Lecture. Invest Ophthalmol Vis Sci 47:1754-1767.
12. Evans DJ, Noden DM. 2006. Spatial relations between avian craniofacial neural crest and paraxial mesoderm cells. Dev Dyn 235:1310-1325.
13. Flugel-Koch C, Ohlmann A, Piatigorsky J, Tamm ER. 2002. Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice. Dev Dyn 225:111-125.
14. Gage PJ, Camper SA. 1997. Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation. HumMol Genet 6:457-464.
15. Gage PJ, Suh H, Camper SA. 1999. Dosage requirement of Pitx2 for development of multiple organs. Development 126:4643-4651.
16. Gage PJ, Rhoades W, Prucka SK, Hjalt T. 2005. Fate maps of neural crest and mesoderm in the mammalian eye. Invest Ophthalmol Vis Sci 46: 4200-4208.
17. Gould DB, Smith RS, John SW. 2004. Anterior segment development relevant to glaucoma. Int J Dev Biol 48:1015-1029.
18. Hay ED. 1979. Development of the vertebrate cornea. Int Rev Cytol 63:263-322.
19. Hayashi S, McMahon AP. 2002. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 244:305-318.
20. Idrees F, Vaideanu D, Fraser SG, Sowden JC, Khaw PT. 2006. A review of anterior segment dysgeneses. Surv Ophthalmol 51:213-231.
21. Ittner LM, Wurdak H, Schwerdtfeger K, Kunz T, Ille F, Leveen P, Hjalt TA, Suter U, Karlsson S, Hafezi F, Born W, Sommer L. 2005. Compound developmental eye disorders following inactivation of TGFbeta signaling in neuralcrest stem cells. J Biol 4:11.
22. Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM. 2000. Fate of the mammalian cardiac neural crest. Development 127:1607-1616. (Pubitemid 30234918)
23. Johnston MC, Noden DM, Hazelton RD, Coulombre JL, Coulombre AJ. 1979. Origins of avian ocular and periocular tissues. Exp Eye Res 29:27-43.
24. Kidson SH, Kume T, Deng K, Winfrey V, Hogan BL. 1999. The forkhead/wingedhelix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. Dev Biol 211:306-322.
25. Kim BS, Savinova OV, Reedy MV, Martin J, Lun Y, Gan L, Smith RS, Tomarev SI, John SW, Johnson RL. 2001. Targeted disruption of the myocilin gene (Myoc) suggests that human glaucomacausing mutations are gain of function. Mol Cell Biol 21:7707-7713.
26. Liu C, Liu W, Palie J, Lu MF, Brown NA, Martin JF. 2002. Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development 129:5081-5091. (Pubitemid 35355924)
27. Lu MF, Pressman C, Dyer R, Johnson RL, Martin JF. 1999. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Nature 401:276-278. (Pubitemid 129515540)
28. Matt N, Dupe V, Garnier JM, Dennefeld C, Chambon P, Mark M, Ghyselinck NB. 2005. Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development 132: 4789-4800.
29. Matt N, Ghyselinck NB, Pellerin I, Dupe V. 2008. Impairing retinoic acid ÿirregular in the neural crest cells is sufficient to alter entire eye morphogenesis. Dev Biol 320:140-148.
30. Mimiwati Z, Mackey DA, Craig JE, Mackinnon JR, Rait JL, Liebelt JE, Ayala-Lugo R, Vollrath D, Richards JE. 2006. Nail-patella syndrome and its association with glaucoma: a review of eight families. Br J Ophthalmol 90:1505-1509.
31. Pressman CL, Chen H, Johnson RL. 2000. LMX1B, a LIM homeodomain class transcription factor, is necessary for normal development of multiple tissues in the anterior segment of the murine eye. Genesis 26:15-25.
32. Qiu Q, Chen H, Johnson RL. 2009. Lmx1b-expressing cells in the mouse limb bud define a dorsal mesenchymal lineage compartment. Genesis 47:224-233.
33. Saika S, Liu CY, Azhar M, Sanford LP, Doetschman T, Gendron RL, Kao CW, Kao WW. 2001. TGFbeta2 in corneal morphogenesis during mouse embryonic development. Dev Biol 240:419-432.
34. Schweizer H, Johnson RL, Brand-Saberi B. 2004. Characterization of migration behavior of myogenic precursor cells in the limb bud with respect to Lmx1b expression. Anat Embryol (Berl) 208:7-18.
35. Smith RS, Zabaleta A, Savinova OV, John SW. 2001. The mouse anterior chamber angle and trabecular meshwork develop without cell death. BMC Dev Biol 1:3.
36. Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71. (Pubitemid 29036285)
37. Vollrath D, Jaramillo-Babb VL, Clough MV, McIntosh I, Scott KM, Lichter PR, Richards JE. 1998. Loss-of-function mutations in the LIM-homeodomain gene, LMX1B, in nail-patella syndrome. Hum Mol Genet 7:1091-1098.