메뉴 건너뛰기




Volumn 28, Issue SUPPL. 1, 2010, Pages 28-34

Controversies in design and interpretation of adjuvant clinical trials

Author keywords

anastrozole; aromatase inhibitors; endocrine therapy; exemestane; letrozole; tamoxifen

Indexed keywords

ANASTROZOLE; ESTROGEN RECEPTOR; EXEMESTANE; LETROZOLE; PROGESTERONE RECEPTOR; TAMOXIFEN; TAMOXIFEN CITRATE;

EID: 77954978444     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357907.2010.501633     Document Type: Review
Times cited : (4)

References (32)
  • 1
    • 0037157603 scopus 로고    scopus 로고
    • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomised trial
    • ATAC Trialists' Group Erratum in: Lancet 2002;360(9344): 1520
    • Baum, M.; Budzar, A.U.; Cuzick, J.; Forbes, J.; Houghton, J.H.; Klijn, J.G.; Sahmoud, T. ATAC Trialists' Group. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet 2002, 359(9324), 2131-2139. Erratum in: Lancet 2002;360(9344):1520.
    • (2002) Lancet , vol.359 , Issue.9324 , pp. 2131-2139
    • Baum, M.1    Budzar, A.U.2    Cuzick, J.3    Forbes, J.4    Houghton, J.H.5    Klijn, J.G.6    Sahmoud, T.7
  • 2
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer
    • ATAC Trialists' Group
    • Howell, A.; Cuzick, J.; Baum, M.; Buzdar, A.; Dowsett, M.; Forbes, J.F.; Hoctin-Boes, G.; Houghton, J.; Locker, G.Y.; Tobias, J.S. ATAC Trialists' Group. Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 2005, 365(9453), 60-62.
    • (2005) Lancet , vol.365 , Issue.9453 , pp. 60-62
    • Howell, A.1    Cuzick, J.2    Baum, M.3    Buzdar, A.4    Dowsett, M.5    Forbes, J.F.6    Hoctin-Boes, G.7    Houghton, J.8    Locker, G.Y.9    Tobias, J.S.10
  • 3
    • 37449028688 scopus 로고    scopus 로고
    • Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial
    • Arimidex Tamoxifen Alone or in Combination (ATAC) Trialists' Group
    • Forbes, J.F.; Cuzick, J.; Buzdar, A.; Howell, A.; Tobias, J.S.; Baum, M. Arimidex, Tamoxifen, Alone or in Combination (ATAC) Trialists' Group. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol 2008, 9(1), 45-53.
    • (2008) Lancet Oncol , vol.9 , Issue.1 , pp. 45-53
    • Forbes, J.F.1    Cuzick, J.2    Buzdar, A.3    Howell, A.4    Tobias, J.S.5    Baum, M.6
  • 6
    • 77954996615 scopus 로고    scopus 로고
    • Letrozole vs. tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor positive breast cancer. Update of the BIG 1-98 primary core analysis
    • BIG 1-98 Collaborative Group March11-14, St. Gallen, Switzerland
    • Thürlimann, B.; BIG 1-98 Collaborative Group. Letrozole vs. tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor positive breast cancer. Update of the BIG 1-98 primary core analysis. 11th International St. Gallen Oncology Conferences: Primary Therapy of Early Breast Cancer; March 11-14, 2009; St. Gallen, Switzerland. Abstract 0161.
    • (2009) 11th International St. Gallen Oncology Conferences: Primary Therapy of Early Breast Cancer
    • Thürlimann, B.1
  • 9
    • 34447574894 scopus 로고    scopus 로고
    • Improved overall survival in postmenopausal women with early breast cancer after anastrozole initiated after treatment with tamoxifen compared with continued tamoxifen: The ARNO 95 Study
    • Kaufmann, M.; Jonat, W.; Hilfrich, J.; Eidtmann, H.; Gademann, G.; Zuna, I.; von Minckwitz, G. Improved overall survival in postmenopausal women with early breast cancer after anastrozole initiated after treatment with tamoxifen compared with continued tamoxifen: the ARNO 95 Study. J Clin Oncol 2007, 25(19), 2664-2670.
    • (2007) J Clin Oncol , vol.25 , Issue.19 , pp. 2664-2670
    • Kaufmann, M.1    Jonat, W.2    Hilfrich, J.3    Eidtmann, H.4    Gademann, G.5    Zuna, I.6    Von Minckwitz, G.7
  • 10
    • 33845283976 scopus 로고    scopus 로고
    • The benefits of sequencing adjuvant tamoxifen and anastrozole in postmenopausal women with hormone-responsive early breast cancer: 5 year-analysis of ABCSG Trial 8
    • Abstract 13
    • Jakesz, R.; Gnant, M.; Greil, R.; Tausch, C.; Samonigg, H.; Kwasny, W.; Kubista, E.; Stierer, M.; Luschin, G.; Mittlboeck, M. The benefits of sequencing adjuvant tamoxifen and anastrozole in postmenopausal women with hormone-responsive early breast cancer: 5 year-analysis of ABCSG Trial 8. Breast Cancer Res Treat 2005, 94(Suppl 1), S10. Abstract 13.
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.SUPPL. .1
    • Jakesz, R.1    Gnant, M.2    Greil, R.3    Tausch, C.4    Samonigg, H.5    Kwasny, W.6    Kubista, E.7    Stierer, M.8    Luschin, G.9    Mittlboeck, M.10
  • 13
    • 23444435619 scopus 로고    scopus 로고
    • The ABCSG Extended adjuvant treatment with anastrozole: Results from the Austrian Breast and Colorectal Cancer Study Group Trial 6a (ABCSG-6a)
    • on behalf of Abstract 527
    • Jakesz, R.; Samonigg, H.; Greil, R.; Gnant, M.; Schmid, M.; Kwasny, W.; Kubista, E.; Mlineritsch, B.; Tausch, C.; Stierer, M.; on behalf of the ABCSG Extended adjuvant treatment with anastrozole: results from the Austrian Breast and Colorectal Cancer Study Group Trial 6a (ABCSG-6a). J Clin Oncol 2005, 23(16S), 10s. Abstract 527.
    • (2005) J Clin Oncol , vol.23 , Issue.16 S
    • Jakesz, R.1    Samonigg, H.2    Greil, R.3    Gnant, M.4    Schmid, M.5    Kwasny, W.6    Kubista, E.7    Mlineritsch, B.8    Tausch, C.9    Stierer, M.10
  • 14
    • 42949104549 scopus 로고    scopus 로고
    • Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: Intention-to-treat analysis of the National Surgical Adjuvant Breast and Bowel Project B-33 trial
    • Mamounas, E.P.; Jeong, J.H.; Wickerham, D.L.; Smith, R.; Geyer, C.; Ganz, P.; Land, S.; Hutchins, L.; Eisen, A.; Ingle, J.; Costantino, J.; Wolmark, N. Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: intention-to-treat analysis of the National Surgical Adjuvant Breast And Bowel Project B-33 trial. J Clin Oncol 2008, 26(12), 1965-1971.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 1965-1971
    • Mamounas, E.P.1    Jeong, J.H.2    Wickerham, D.L.3    Smith, R.4    Geyer, C.5    Ganz, P.6    Land, S.7    Hutchins, L.8    Eisen, A.9    Ingle, J.10    Costantino, J.11    Wolmark, N.12
  • 15
    • 34547852275 scopus 로고    scopus 로고
    • Progress and promise: Highlights of the international expert consensus on the primary therapy of early breast cancer 2007
    • 10th St. Gallen conference. Erratum in: Ann Oncol 2007;18(11): 1917
    • Goldhirsch, A.; Wood, W.C.; Gelber, R.D.; Coates, A.S.; Thürlimann, B.; Senn, H.J. 10th St. Gallen conference. Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Ann Oncol 2007, 18(7), 1133-1144. Erratum in: Ann Oncol 2007;18(11): 1917.
    • (2007) Ann Oncol , vol.18 , Issue.7 , pp. 1133-1144
    • Goldhirsch, A.1    Wood, W.C.2    Gelber, R.D.3    Coates, A.S.4    Thürlimann, B.5    Senn, H.J.6
  • 17
    • 69449090120 scopus 로고    scopus 로고
    • Panel members. Thresholds for therapies: Highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009
    • Goldhirsch, A.; Ingle, J.N.; Gelber, R.D.; Coates, A.S.; Thürlimann, B.; Senn, H.J.; Panel members. Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009. Ann Oncol 2009, 20(8), 1319-1329.
    • (2009) Ann Oncol , vol.20 , Issue.8 , pp. 1319-1329
    • Goldhirsch, A.1    Ingle, J.N.2    Gelber, R.D.3    Coates, A.S.4    Thürlimann, B.5    Senn, H.J.6
  • 18
    • 24644503672 scopus 로고    scopus 로고
    • Aromatase inhibitors in adjuvant therapy of breast cancer: Before, instead of, or beyond tamoxifen
    • Pritchard, K.I. Aromatase inhibitors in adjuvant therapy of breast cancer: before, instead of, or beyond tamoxifen. J Clin Oncol 2005, 23(22), 4850-4852.
    • (2005) J Clin Oncol , vol.23 , Issue.22 , pp. 4850-4852
    • Pritchard, K.I.1
  • 19
    • 65749106867 scopus 로고    scopus 로고
    • Tamoxifen and anastrozole as a sequencing strategy in postmenopausal women with hormone-responsive early breast cancer: Updated data from the Austrian breast and colorectal cancer study group trial 8
    • Abstract 14
    • Jakesz, R.; Gnant, M.; Griel, R.; Tausch, C.; Samonigg, H.; Kwansy, W.; Kubista, E.; Stierer, M.; Luschin, G.; Rucklinger, E.; Mittibock, M. Tamoxifen and anastrozole as a sequencing strategy in postmenopausal women with hormone-responsive early breast cancer: updated data from the Austrian breast and colorectal cancer study group trial 8. Cancer Res 2009, 69(Suppl 2), 67s. Abstract 14.
    • (2009) Cancer Res , vol.69 , Issue.SUPPL. 2
    • Jakesz, R.1    Gnant, M.2    Griel, R.3    Tausch, C.4    Samonigg, H.5    Kwansy, W.6    Kubista, E.7    Stierer, M.8    Luschin, G.9    Rucklinger, E.10    Mittibock, M.11
  • 20
    • 23444446523 scopus 로고    scopus 로고
    • ABCSG and the GABG Switching of postmenopausal women with endocrineresponsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: Combined results of ABCSG trial 8 and ARNO 95 trial
    • Jakesz, R.; Jonat, W.; Gnant, M.; Mittlboeck, M.; Greil, R.; Tausch, C.; Hilfrich, J.; Kwasny, W.; Menzel, C.; Samonigg, H.; Seifert, M.; Gademann, G.; Kaufmann, M.; Wolfgang, J.; ABCSG and the GABG Switching of postmenopausal women with endocrineresponsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and ARNO 95 trial. Lancet 2005, 366(9484), 455-462.
    • (2005) Lancet , vol.366 , Issue.9484 , pp. 455-462
    • Jakesz, R.1    Jonat, W.2    Gnant, M.3    Mittlboeck, M.4    Greil, R.5    Tausch, C.6    Hilfrich, J.7    Kwasny, W.8    Menzel, C.9    Samonigg, H.10    Seifert, M.11    Gademann, G.12    Kaufmann, M.13    Wolfgang, J.14
  • 21
    • 33344472551 scopus 로고    scopus 로고
    • Should aromatase inhibitors be used as initial adjuvant treatment or sequenced after tamoxifen?
    • Cuzick, J.; Sasieni, P.; Howell, A. Should aromatase inhibitors be used as initial adjuvant treatment or sequenced after tamoxifen? Br J Cancer 2006, 94(4), 460-464.
    • (2006) Br J Cancer , vol.94 , Issue.4 , pp. 460-464
    • Cuzick, J.1    Sasieni, P.2    Howell, A.3
  • 23
    • 0029759541 scopus 로고    scopus 로고
    • Annual hazard rates of recurrence for breast cancer after primary therapy
    • Saphner, T.; Tormey, D.C.; Gray, R. Annual hazard rates of recurrence for breast cancer after primary therapy. J Clin Oncol 1996, 14(10), 2738-2746.
    • (1996) J Clin Oncol , vol.14 , Issue.10 , pp. 2738-2746
    • Saphner, T.1    Tormey, D.C.2    Gray, R.3
  • 24
    • 32944457272 scopus 로고    scopus 로고
    • Retrospective analysis of time to recurrence in the ATAC trial according to hormone receptor status: An hypothesis-generating study
    • Dowsett, M.; Cuzick, J.; Wale, C.; Howell, T.; Houghton, J.; Baum, M. Retrospective analysis of time to recurrence in the ATAC trial according to hormone receptor status: an hypothesis-generating study. J Clin Oncol 2005, 23(30), 7512-7517.
    • (2005) J Clin Oncol , vol.23 , Issue.30 , pp. 7512-7517
    • Dowsett, M.1    Cuzick, J.2    Wale, C.3    Howell, T.4    Houghton, J.5    Baum, M.6
  • 29
    • 17044400164 scopus 로고    scopus 로고
    • Forest plots and the interpretation of subgroups
    • Cuzick, J. Forest plots and the interpretation of subgroups. Lancet 2005, 365(9467), 1308.
    • (2005) Lancet , vol.365 , Issue.9467 , pp. 1308
    • Cuzick, J.1
  • 30
    • 34447248786 scopus 로고    scopus 로고
    • Endpoints in adjuvant treatment trials: A systematic review of the literature in colon cancer and proposed definitions for future trials
    • Punt, C.J.; Buyse, M.; Köhne, C.H.; Hohenberger, P.; Labianca, R.; Schmoll, H.J.; Pahlman, L.; Sobrero, A.; Douillard, J.Y. Endpoints in adjuvant treatment trials: a systematic review of the literature in colon cancer and proposed definitions for future trials. J Natl Cancer Inst 2007, 99(13), 998-1003.
    • (2007) J Natl Cancer Inst , vol.99 , Issue.13 , pp. 998-1003
    • Punt, C.J.1    Buyse, M.2    Köhne, C.H.3    Hohenberger, P.4    Labianca, R.5    Schmoll, H.J.6    Pahlman, L.7    Sobrero, A.8    Douillard, J.Y.9
  • 31
    • 45849143717 scopus 로고    scopus 로고
    • Primary endpoints for randomised trials of cancer therapy
    • Cuzick, J. Primary endpoints for randomised trials of cancer therapy. Lancet 2008, 371(9631), 2156-2158.
    • (2008) Lancet , vol.371 , Issue.9631 , pp. 2156-2158
    • Cuzick, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.