Focus on Molecules: Nuclear hormone receptor Nr2e3: Impact on retinal development and disease

Experimental Eye Research

Volumn 91, Issue 2, 2010, Pages 116-117

  Mollema, Nissa ^a   Haider, Neena B ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Cones; Enhanced S cone syndrome; Nr2e3; Nuclear receptor; Photoreceptors; Retinal degeneration; Rods; RP

Indexed keywords

CELL NUCLEUS RECEPTOR; CONE OPSIN; GUANINE NUCLEOTIDE BINDING PROTEIN; NUCLEAR RECEPTOR NR2E3; TRANSDUCIN; UNCLASSIFIED DRUG;

AUTOSOMAL DOMINANT DISORDER; AUTOSOMAL RECESSIVE DISORDER; CELL PROLIFERATION; CLUMPED PIGMENTARY RETINAL DEGENERATION; ELECTRORETINOGRAM; ENHANCED S CONE SYNDROME; GENE EXPRESSION REGULATION; GENE MUTATION; GOLDMANN FAVRE SYNDROME; HUMAN; NONHUMAN; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; RETINA CONE; RETINA DEVELOPMENT; RETINA DISEASE; RETINA ROD; RETINITIS PIGMENTOSA; SHORT SURVEY;

EYE PROTEINS; HUMANS; ORPHAN NUCLEAR RECEPTORS; RETINA; RETINAL DEGENERATION;

EID: 77954958070     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.04.013     Document Type: Short Survey

References (4)

1. Corbo J.C., Cepko C.L. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. PLoS Genet. 2005 Aug, 1(2). e11.
2. Haider N.B., Jacobson S.G., Cideciyan A.V., Swiderski R., Streb L.M., Searby C., Beck G., Hockey R., Hanna D.B., Gorman S., Duhl D., Carmi R., Bennett J., Weleber R.G., Fishman G.A., Wright A.F., Stone E.M., Sheffield V.C. Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate. Nat. Genet. 2000 Feb, 24(2):127-131.
3. Haider N.B., Mollema N., Gaule M., Yuan Y., Sachs A.J., Nystuen A.M., Naggert J.K., Nishina P.M. Nr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransduction. Exp. Eye Res. 2009, 89:365-372.
4. Hening A.K., Peng G.H., Chen S. Regulation of photoreceptor gene expression by Crx-associated transcription factor network. Brain Res. 2008 Feb 4, 1192:1114-1133.