Antiparasitic activity of alkaloids from plant species of Papua New Guinea and Australia

International Journal of Antimicrobial Agents

Volumn 36, Issue 3, 2010, Pages 275-279

  Fernandez, Liza S ^a   Sykes, Melissa L ^a   Andrews, Katherine T ^a   Avery, Vicky M ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

Alkaloid; Antimalarial; Antitrypanosomal; Flindersia; Plant; Stage specificity

Indexed keywords

ALKALOID DERIVATIVE; ANTIPARASITIC AGENT; ARTEMISININ; CHLOROQUINE; DIMETHYLISOBORREVERINE; FLINDEROLE A; FLINDEROLE B; FLINDEROLE C; HEMOZOIN; ISOBORREVERINE; LIRIODENINE; PENTAMIDINE; PUROMYCIN; PYRIMETHAMINE; UNCLASSIFIED DRUG; VOACAMINE; XYLOPINE; ALKALOID; PLANT EXTRACT;

ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ANTIMALARIAL DRUG SUSCEPTIBILITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; AUSTRALIA; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; EMBRYO; FEMALE; FLINDERSIA AMBOINENSIS; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PAPUA NEW GUINEA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RUTACEAE; SCHIZONT; STEPHANIA; STEPHANIA ZIPPELIANA; TRANSMISSION ELECTRON MICROSCOPY; TROPHOZOITE; TRYPANOSOMA BRUCEI; VOACANGA; VOACANGA PAPUANA; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; EPITHELIUM CELL; IC50; ISOLATION AND PURIFICATION; TOXICITY; TRYPANOSOMA BRUCEI BRUCEI;

ALKALOIDS; ANIMALS; ANTIPARASITIC AGENTS; AUSTRALIA; CELL LINE; EPITHELIAL CELLS; HUMANS; INHIBITORY CONCENTRATION 50; PAPUA NEW GUINEA; PLANT EXTRACTS; PLASMODIUM FALCIPARUM; RUTACEAE; STEPHANIA; TRYPANOSOMA BRUCEI BRUCEI; VOACANGA;

EID: 77954956842     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2010.05.008     Document Type: Article

References (15)

1. Schlitzer M. Malaria chemotherapeutics part I: history of antimalarial drug development, currently used therapeutics, and drugs in clinical development. ChemMedChem 2007, 2:944-986.
2. Hyde J.E. Drug-resistant malaria-an insight. FEBS J 2007, 274:4688-4698.
3. World Health Organisation. World malaria report. Geneva, Switzerland: WHO; 2008.
4. Fernandez L.S., Jobling M.F., Andrews K.T., Avery V.M. Antimalarial activity of natural product extracts from Papua New Guinean and Australian plants against Plasmodium falciparum. Phytother Res 2008, 22:1409-1412.
5. Fernandez L.S., Buchanan M.S., Carroll A.R., Feng Y.J., Quinn R.J., Avery V.M. Flinderoles A-C: antimalarial bis-indole alkaloids from Flindersia species. Org Lett 2009, 11:329-332.
6. 13C chemical shift assignments. Magn Reson Chem 1999, 37:676-681.
7. Guinaudeau H., Leboeuf M., Cave A. Aporphinoid alkaloids, III. J Nat Prod 1983, 46:761-835.
8. Ruangrungsi N., Rivepiboon A., Lange G.L., Lee M., Decicco C.P., Picha P., et al. Constituents of Paramichelia baillonii: a new antitumor germacranolide alkaloid. J Nat Prod 1987, 50:891-896.
9. Sykes M.L., Avery V.M. Development of an Alamar Blue™ viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427. Am J Trop Med Hyg 2009, 81:665-674.
10. Parapini S., Basilico N., Pasini E., Egan T.J., Olliaro P., Taramelli D., et al. Standardization of the physicochemical parameters to assess in vitro the β-hematin inhibitory activity of antimalarial drugs. Exp Parasitol 2000, 96:249-256.
11. Glauert A.M. Fixation, dehydration and embedding of biological specimens. Practical methods in electron microscopy 1974, vol. 3:1-207. North-Holland Publishing Company, Amsterdam, The Netherlands.
12. Likhitwitayawuid K., Angerhofer C.K., Chai H., Pezzuto J.M., Cordell G.A., Ruangrungsi N. Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei. J Nat Prod 1993, 56:1468-1478.
13. Federici E., Palazzino G., Nicoletti M., Galeffi C. Antiplasmodial activity of the alkaloids of Peschiera fuchsiaefolia. Planta Med 2000, 66:93-95.
14. Wirasathien L., Boonarkart C., Pengsuparp T., Suttisri R. Biological activities of alkaloids from Pseuduvaria setosa. Pharm Biol 2006, 44:274-278.
15. Waechter A.-I., Cavé A., Hocquemiller R., Bories C., Muñoz V., Fournet A. Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae). Phytother Res 1999, 13:175-177.