The effect of the NMDA receptor antagonist dizocilpine on behavioral manifestations of serotonin and adrenergic antidepressants in rats

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 32, Issue 2, 2010, Pages 123-128

  Pruus, K ^a   Rudissaar, R ^a   Allikmets, L ^a   Harro, J ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

CITALOPRAM; DESIPRAMINE; DIZOCILPINE; FLUOXETINE; MAPROTILINE; ADRENERGIC RECEPTOR AFFECTING AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; DIZOCILPINE MALEATE; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; DEPRESSION; DRUG ACTIVITY; DRUG EFFECT; FORCED SWIMMING TEST; IMMOBILIZATION; LOCOMOTION; MALE; NONHUMAN; OPEN FIELD BEHAVIOR; RAT; ANIMAL; ANIMAL BEHAVIOR; DISEASE MODEL; DOSE RESPONSE; DRUG INTERACTION; MOTOR ACTIVITY; PATHOPHYSIOLOGY; SWIMMING; WISTAR RAT;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; DEPRESSION; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR; SEROTONIN UPTAKE INHIBITORS; SWIMMING;

EID: 77954946682     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2010.32.2.1481727     Document Type: Article

References (26)

1. D'Aquila, P.S., Collu, M., Gessa, G.L., Serra, G. The role of dopamine in the mechanism of action of antidepressant drugs. Eur J Pharmacol 2000, 405(1-3): 365-73.
2. Brunello, N., Mendlewicz, J., Kasper, S., et al. The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. Eur Neuropsychopharmacol 2002, 12(5): 461-75.
3. Middlemiss, D.N., Price, G.W., Watson, J.M. Serotonergic targets in depression. Curr Opin Pharmacol 2002, 2(1): 18-22.
4. Petrie, R.X., Reid, I.C., Stewart, C.A. The N-methyl-D-aspartate receptor, synaptic plasticity, and depressive disorder. Pharmacol Ther 2000, 87(1): 11-25.
5. Krystal, J.H., Sanacora, G., Blumberg, H. et al. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Mol Psychiatry 2002, 7(Suppl.1): 71-80.
6. Nowak, G., Ordway, G.A., Paul, I.A. Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Res 1995, 675(1-2): 157-64.
7. Paul, I.A., Skolnick, P. Glutamate and depression: Clinical and preclinical studies. Ann N Y Acad Sci 2003, 1003: 250-72.
8. Skolnick, P. Antidepressants for the new millennium. Eur J Pharmacol 1999, 375(1-3): 31-40.
9. Andine, P., Widermark, N., Axelsson, R. et al. Characterization of dizocilpine-induced behavior as a putative rat model of psychosis. J Pharmacol Exp Ther 1999, 290(3): 1393-408.
10. Maj, J., Rogoz, Z., Skuza, G. Antidepressant drugs increase the locomotor hyperactivity induced by dizocilpine in rats. J Neural Transm Gen Sect 1991, 85(3): 169-79.
11. Maj, J., Rogoz, Z., Skuza, G., Wedzony, K. The synergistic effect of fluoxetine on the locomotor hyperactivity induced by dizocilpine, a non-competitive NMDA receptor antagonist. J Neural Transm 1996, 103(1-2): 131-46.
12. Porsolt, R.D., Anton, G., Blavet, N., Jalfre, M. Behavioral despair in rats, a new model sensitive to antidepressant treatments. Eur J Pharmacol 1978, 47(4): 379-91.
13. Porsolt, R.D., Bertin, A., Blavet, N., Deniel, M., Jalfre, M. Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity. Eur J Pharmacol 1979, 57(2-3): 201-10.
14. Liljequist, S., Ossowska, K., Grabowska-Anden, M., Anden, N.E. Effect of the NMDA receptor antagonist, dizocilpine, on locomotor activity and on the metabolism of dopamine in various brain areas of mice. Eur J Pharmacol 1991, 195(1): 55-61.
15. Carey, R.J., Dai, H., Gui, J. Effects of dizocilpine on motor activity and memory. Psychopharmacology 1998, 137(3): 241-6.
16. Maj, J., Rogoz, Z., Skuza, G. The effects of combined treatment with dizocilpine and antidepressant drugs in the forced swimming test in rats. Pol J Pharmacol Pharm 1992, 44(3): 217-26.
17. Borsini, F. Role of the serotonergic system in the forced swimming test. Neurosci Biobehav Rev 1995, 19(3): 377-95.
18. Petit-Demouliere, B., Chenu, F., Bourin, M. Forced swimming test in mice: A review of antidepressant activity. Psychopharmacology (Berl) 2005, 177(3): 245-55.
19. Borsini, F., Meli, A. Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology (Berl) 1988, 94(2): 147-60.
20. Rogoz, Z., Skuza, G., Maj, J., Danysz, W. Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats. Neuropharmacology 2002, 42(8): 1024-30.
21. Loscher, W., Annies, R., Honack, D. The N-methyl-D-aspartate receptor antagonist dizocilpine induces increases in dopamine and serotonin metabolism in several brain regions of rats. Neurosci Lett 1991, 128(2): 191-4.
22. Whitton, P.S., Biggs, C.S., Pearce, B.R., Fowler, L.J. Regional effects of dizocilpine on dopamine and its metabolites studied by in vivo microdialysis. Neurosci Lett 1992, 142(1): 5-8.
23. Yan, Q.S., Reith, M.E., Jobe, P.C., Dailey, J.W. Dizocilpine increases not only dopamine but also serotonin and norepinephrine transmissions in the nucleus accumbens as measured by microdialysis in freely moving rats. Brain Res 1997, 765(1): 149-58.
24. Callado, L.F., Hopwood, S.E., Hancock, P.J., Stamford, J.A. Effects of dizocilpine (MK 801) on noradrenaline, serotonin and dopamine release and uptake. Neuroreport 2000, 11(1): 173-6.
25. Loscher, W., Honack, D. The behavioural effects of dizocilpine in rats: Involvement of dopaminergic, serotonergic and noradrenergic systems. Eur J Pharmacol 1992, 215(2-3): 199-208.
26. Felton, T.M., Kang, T.B., Hjorth, S., Auerbach, S.B. Effects of selective serotonin and serotonin/noradrenaline reuptake inhibitors on extracellular serotonin in rat diencephalon and frontal cortex. Naunyn Schmiedebergs Arch Pharmacol 2003, 367(3): 297-305.