Wilms' tumor 1 gene (WT1) is overexpressed and provides an oncogenic function in pediatric nephroblastomas harboring the wild-type WT1

Oncology Letters

Volumn 1, Issue 4, 2010, Pages 615-619

  Sangkhathat, Surasak ^a,b   Kanngurn, Samornmas ^a,b   Chaiyapan, Welawee ^a,b   Gridist, Podchanaporn ^a,b   Maneechay, Wanwisa ^b  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

^b PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

catenin; Nephroblastoma; Wilms' tumor; Wilms' tumor 1 gene

Indexed keywords

BETA CATENIN; MESSENGER RNA; SMALL INTERFERING RNA; WT1 PROTEIN;

APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY PARENCHYMA; KIDNEY TUMOR; NEPHROBLASTOMA; NEUROBLASTOMA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL; TUMOR GROWTH;

EID: 77954944878     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol_00000109     Document Type: Article

References (16)

1. Beckwith JB, kiviat NB and Bonadio JF: Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms' tumor. Pediatr Pathol 10: 1-36, 1990.
2. Li CM, kim CE, Margolin AA, et al: CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors. Am J Pathol 165: 1943-1953, 2004.
3. Rivera MN, kim WJ, Wells J, et al: An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science 315: 642-645, 2007.
4. Perotti D, Gamba B, Sardella M, et al: Functional inactivation of the WTX gene is not a frequent event in Wilms' tumors. Oncogene 27: 4625-4632, 2008.
5. Lee SB and Haber DA: Wilms tumor and the WT1 gene. Exp Cell Res 264: 74-99, 2001.
6. Moore AW, McInnes L, kreidberg J, Hastie ND and Schedl A: YAC complementation shows a requirement for WT1 in the development of epicardium, adrenal gland and throughout neph-rogenesis. Development 126: 1845-1857, 1999
7. Sangkhathat S, Chotsampancharaen T, kayasut k, Patrapinyokul S, Chiengkriwate P, kitichet R and Maipang M: Outcomes of pediatric nephroblastoma in southern Thailand. Asian Pac J Cancer Prev 9: 643-647, 2008.
8. Oji Y, Yamamoto H, Nomura M, et al: Overexpression of the Wilms' tumor gene WT1 in colorectal adenocarcinoma. Cancer Sci 94: 712-717, 2003.
9. Sangkhathat S, kusafuka T, Miao J, et al: In vitro RNA interference against β-catenin inhibits the proliferation of pediatric Hepatic tumors. Int J Oncol 28: 715-722, 2006.
10. Wanitsuwan W, kanngurn S, Boonpipattanapong T, Sangthong R and Sangkhathat S: Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers. World J Gastroenterol 14: 6052-6059, 2008.
11. Navakanit R, Graidist P, Leeanansaksiri W and dechsukum C: Growth inhibition of breast cancer cell line MCF-7 by siRNA silencing of Wilms tumor 1 gene. J Med Assoc Thai 90: 2416-2421, 2007
12. Sangkhathat S, Nara k, kusafuka T, Yoneda A and Fukuzawa M: Artifcially accumulated β-catenin inhibits proliferation and induces neurite extension of neuroblastoma cell line NB-1 via up-regulation of trkA. Oncol Rep 16: 1197-1203, 2006.
13. Fukuzawa R, Anaka MR, Weeks RJ, Morison IM and Reeve AE: Canonical WNT signaling determines lineage specifcity in Wilms tumour. Oncogene 28: 1063-1075, 2009
14. Fukuzawa R, Heathcott RW, More HE and Reeve AE: Sequential WT1 and CTNNB1 mutations and alterations of beta-catenin localisation in intralobar nephrogenic rests and associated Wilms tumours: two case studies. J Clin Pathol 60: 1013-1016, 2007
15. Fukuzawa R, Heathcott RW, Sano M, Morison IM, Yun K and Reeve AE: Myogenesis in Wilms' tumors is associated with mutations of the WT1 gene and activation of Bcl-2 and the Wnt signaling pathway. Pediatr d ev Pathol 7:125-137, 2004
16. Hohenstein P and Hastie ND: The many facets of the Wilms' tumor gene, WT1. Hum Mol Genet 15: R196-R201, 2006.