Combination of vascular targeting PDT with combretastatin A4 phosphate

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7380, Issue , 2009, Pages

  He, Chong ^a   Fateye, Babasola ^a   Chen, Bin ^a  

^a UNIVERSITY OF THE SCIENCES   (United States)

Author keywords

combretastatin; endothelial cells; myosin light chain kinase (MLCK); photodynamic therapy (PDT); tumor vascular targeting; verteporfin

Indexed keywords

BLOOD FLOW; BLOOD SUPPLY; CANCER THERAPY; CLINICAL STUDY; COMBRETASTATIN; LASER LIGHTS; MYOSIN LIGHT CHAIN KINASE; PROSTATE TUMOR; SURVIVAL AND GROWTH; THERAPEUTIC AGENTS; THERAPEUTIC EFFECTS; TUMOR CELLS; TUMOR RESPONSE; TUMOR VASCULATURE; VASCULAR FUNCTIONS; VERTEPORFIN; WESTERN-BLOT ANALYSIS;

BLOOD; CELL DEATH; DISEASES; ENDOTHELIAL CELLS; ENZYMES; PHOTOSENSITIZERS; PLASMONS; TUMORS;

PHOTODYNAMIC THERAPY;

EID: 77954935748     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.822969     Document Type: Conference Paper

References (14)

1. Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, et al. Photodynamic therapy. J Natl Cancer Inst 1998;90(12):889-905. (Pubitemid 28304157)
2. Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer 2003;3(5):380-7. (Pubitemid 37328858)
3. Detty MR, Gibson SL, Wagner SJ. Current clinical and preclinical photosensitizers for use in photodynamic therapy. J Med Chem 2004;47(16):3897-915. (Pubitemid 38970949)
4. Chen B, Pogue BW, Hoopes PJ, Hasan T. Vascular and cellular targeting for photodynamic therapy. Crit Rev Eukaryot Gene Expr 2006;16(4):279-305.
5. Chen B, Pogue BW, Hoopes PJ, Hasan T. Combining vascular and cellular targeting regimens enhances the efficacy of photodynamic therapy. Int J Radiat Oncol Biol Phys 2005;61(4):1216-26. (Pubitemid 40340918)
6. He C, Agharkar P, Chen B. Intravital microscopic analysis of vascular perfusion and macromolecule extravasation after photodynamic vascular targeting therapy. Pharm Res 2008;25(8):1873-80.
7. Chen B, Pogue BW, Luna JM, Hardman RL, Hoopes PJ, Hasan T. Tumor vascular permeabilization by vascular-targeting photosensitization: effects, mechanism, and therapeutic implications. Clin Cancer Res 2006;12(3):917-23. (Pubitemid 43259874)
8. Brekken RA, Li C, Kumar S. Strategies for vascular targeting in tumors. Int J Cancer 2002;100(2):123-30. (Pubitemid 34666183)
9. Tozer GM, Kanthou C, Baguley BC. Disrupting tumour blood vessels. Nat Rev Cancer 2005;5(6):423-35. (Pubitemid 40791485)
10. Kanthou C, Greco O, Stratford A, Cook I, Knight R, Benzakour O, et al. The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death. Am J Pathol 2004;165(4):1401-11. (Pubitemid 39297744)
11. Tozer GM, Kanthou C, Lewis G, Prise VE, Vojnovic B, Hill SA. Tumour vascular disrupting agents: combating treatment resistance. Br J Radiol 2008;81 Spec No 1:S12-20.
12. Granville DJ, Levy JG, Hunt DW. Photodynamic therapy induces caspase-3 activation in HL-60 cells. Cell Death Differ 1997;4(7):623-8. (Pubitemid 127680698)
13. Peng TI, Chang CJ, Guo MJ, Wang YH, Yu JS, Wu HY, et al. Mitochondrion-targeted photosensitizer enhances the photodynamic effect-induced mitochondrial dysfunction and apoptosis. Ann N Y Acad Sci 2005;1042:419-28.
14. Fazal F, Gu L, Ihnatovych I, Han Y, Hu W, Antic N, et al. Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo. Mol Cell Biol 2005;25(14):6259-66. (Pubitemid 40946573)