Synthesis, nanofeatures, in vitro thrombus lysis activity and in vivo thrombolytic activity of poly-α,β-aspartyl-L-alanine

Nanomedicine

Volumn 5, Issue 5, 2010, Pages 703-714

  Gui, Lin ^a   Zhao, Ming ^a   Wang, Yinye ^b   Qin, Yang ^a   Liu, Jiangyuan ^a   Peng, Shiqi ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

concentration dependent in vitro activity; concentration dependent nanofeature; dose dependent in vivo activity; pH dependent nanofeature; poly a,b dl aspartyl l alanine; SEM image; TEM image

Indexed keywords

ALANINE; DEXTRO ASPARTIC ACID; FIBRINOLYTIC AGENT; NANOPARTICLE; POLY ALPHA,BETA ASPARTYLALANINE; POLYSUCCIMIDE; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; AMIDATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; BLOOD CLOT LYSIS; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG RETENTION; DRUG SYNTHESIS; IN VIVO STUDY; INTESTINE; MACROPHAGE; MALE; MOLECULAR WEIGHT; NANOPHARMACEUTICS; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; STOMACH; THROMBUS; TISSUE WATER; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; FIBRINOLYTIC AGENTS; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; NANOSTRUCTURES; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; THROMBOSIS;

EID: 77954931444     PISSN: 17435889     EISSN: None     Source Type: Journal    
DOI: 10.2217/nnm.10.41     Document Type: Article

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