Radiation induced stress proteins

International Journal of Clinical Pharmacology and Therapeutics

Volumn 48, Issue 7, 2010, Pages 492-493

  Gehrmann, M ^a   Schilling, D ^a   Molls, M ^a   Multhoff, G ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Apoptosis; Cancer therapy; CD77; Gb3; Heat shock protein 70; Hsp70; Hypoxia; Ionizing radiation; Necrosis; Phosphatidylserine

Indexed keywords

HEAT SHOCK PROTEIN 70; PHOSPHATIDYLSERINE;

APOPTOSIS; CANCER CELL CULTURE; CELL HYPOXIA; CELL SURFACE; CELL SURVIVAL; COLORECTAL CANCER; CONFERENCE PAPER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RADIATION EXPOSURE;

EID: 77954924245     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP48492     Document Type: Conference Paper

References (8)

1. Multhoff G, Botzler C,Wiesnet M, Muller E, Meier T, Wilmanns W, Issels RD. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells Int J Cancer. 1995; 61: 272-279.
2. Pfister K, Radons J, Busch R, Tidball JG, Pfeifer M, Freitag L, Feldmann HJ, Milani V, Issels R, Multhoff G. Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis. Cancer. 2007; 110: 926-935. (Pubitemid 47257673)
3. Gehrmann M, Radons J, Molls M, Multhoff G. The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells. Cell Stress Chaperones. 2008; 13:1-10.
4. Gehrmann M, Marienhagen J, Eichholtz-Wirth H, Fritz E, Ellwart J, Jaattela M, Zilch T, Multhoff G. Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells. Cell Death Differ. 2005; 12: 38-51. (Pubitemid 40090027)
5. Gehrmann M, Liebisch G, Schmitz G, Anderson R, Steinem C, De Maio A, Pockley AG, Multhoff G. Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3 PLoS. ONE. 2008; 3: 1925.
6. Schmitt E, Gehrmann M, Brunet M, Multhoff G, Garrido C. Intracellular and extracellular functions of HSPs: repercussions in cancer therapy. J Leucocyte Biol. 2007; 81: 15-27. (Pubitemid 46021247)
7. Powers MV, Clarke PA, Workman P. Death by chaperone. Cell Cycle. 2009; 8: 518-526.
8. Schilling D, Gehrmann M, Steinem C, De Maio A, Pockley AG, Abend M, Molls M, Multhoff G. Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells. FASEB J. 2009; 23: 2467-2477.