Synthesis and biological evaluation of 1-cyclohexyl substituted 3-aminopyrrolidine derivatives as CC chemokine receptor 2 (CCR2) antagonists

Bulletin of the Korean Chemical Society

Volumn 31, Issue 7, 2010, Pages 1827-1828

  Lim, Jee Woong ^a,e   Na, Yongho ^a   Oak, Min Ho ^b   Kim, Jong Hoon ^a,c   Oh, Youna ^a   Lee, Seung Woo ^a   Cho, Heeyeong ^d   Park, Woo Kyu ^d   Choi, Gildon ^d   Kim, Kyoung Rak ^a   Kang, Jongmin ^e  

^a Gyeonggi Institute of Science and Technology Promotion   (South Korea)

^b Research and Development Center   (South Korea)

^c Yonsei University   (South Korea)

^d Korea Research Institute of Chemical Technology   (South Korea)

^e Sejong University   (South Korea)

Author keywords

3 aminopyrrolidine; Antagonist; Chemokine receptor; Inflammation

Indexed keywords

EID: 77954923278     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2010.31.7.1827     Document Type: Article

References (9)

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7. Synthetic method of compound 3, see: PCT patent, WO 2004/050024.
8. All final compounds displayed spectral data (NMR, MS) that were consistent with the assigned structures.
9. BMS CCR2 22 is commercially available from the web site, http://www.tocris.com/dispprod.php?ItemId=208254.