Lpin1 in human visceral and subcutaneous adipose tissue: Similar levels but different associations with lipogenic and lipolytic genes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 299, Issue 2, 2010, Pages

  Miranda, Merce ^a   Escoté, Xavier ^a   Alcaide, María J ^a   Solano, Esther ^a   Ceperuelo Mallafré, Victòria ^a   Hernández, Pilar ^b   Wabitsch, Martin ^c   Vendrell, Joan ^a  

^a HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^b INSTITUT D INVESTIGACIÓ SANITÀRIA PERE VIRGILI IISPV   (Spain)

^c UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Insulin resistance; Lipin 1 gene; Obesity

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CD36 ANTIGEN; DIACYLGLYCEROL ACYLTRANSFERASE; GLUCOSE; GLYCEROL KINASE; HORMONE SENSITIVE LIPASE; INSULIN; MESSENGER RNA; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHODIESTERASE 3B; PHOSPHODIESTERASE III; PHOSPHOENOLPYRUVATE CARBOXYLASE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; COMPLEMENTARY DNA; ISOPRENALINE; LPIN1 PROTEIN, HUMAN; NUCLEAR PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; ANALYTICAL PARAMETERS; ARTICLE; CELL STIMULATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENETIC PARAMETERS; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INFLAMMATION; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; LPIN1 GENE; MALE; METABOLIC PARAMETERS; OBESITY; PRIORITY JOURNAL; REGULATOR GENE; SIMPSON GOLABI BEHMEL SYNDROME; SUBCUTANEOUS FAT; AGED; BIOSYNTHESIS; BODY MASS; CELL CULTURE; CELL DIFFERENTIATION; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; WESTERN BLOTTING;

ADIPOCYTES; ADIPOSE TISSUE; ADRENERGIC BETA-AGONISTS; ADULT; AGED; BLOTTING, WESTERN; BODY MASS INDEX; CELL DIFFERENTIATION; CELLS, CULTURED; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; ISOPROTERENOL; LIPID METABOLISM; LIPOLYSIS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NUCLEAR PROTEINS; SUBCUTANEOUS FAT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77954914138     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00699.2009     Document Type: Article

References (44)

1. Abate N, Garg A, Peshock RM, Stray-Gundersen J, Grundy SM. Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 96: 88-98, 1995.
2. Chang YC, Chang LY, Chang TJ, Jiang YD, Lee KC, Kuo SS, Lee WJ, Chuang LM. The associations of LPIN1 gene expression in adipose tissue with metabolic phenotypes in the Chinese population. Obesity (Silver Spring) 18: 7-12, 2010.
3. Croce MA, Eagon JC, LaRiviere LL, Korenblat KM, Klein S, Finck BN. Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss. Diabetes 56: 2395-2399, 2007. (Pubitemid 47358247)
4. Donkor J, Sparks LM, Xie H, Smith SR, Reue K. Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men. J Clin Endocrinol Metab 93: 233-239, 2008.
5. Drolet R, Richard C, Sniderman AD, Mailloux J, Fortier M, Huot C, Rhéaume C, Tchernof A. Hypertrophy and hyperplasia of abdominal adipose tissues in women. Int J Obes 32: 283-291, 2008.
6. Festuccia WT, Laplante M, Brûlé S, Houde VP, Achouba A, Lachance D, Pedrosa ML, Silva ME, Guerra-Sá R, Couet J, Arsenault M, Marette A, Deshaies Y. Depot-specific effects of the PPARg agonist rosiglitazone on adipose tissue uptake and metabolism. J Lipid Res 50: 1185-1194, 2009.
7. Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC Jr, Kelly DP. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab 4: 199-210, 2006.
8. Grimsey N, Han GS, O'Hara L, Rochford JJ, Carman GM, Siniossoglou S. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. J Biol Chem 283: 29166-29174, 2008.
9. Han GS, Wu WI, Carman GM. The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme. J Biol Chem 281: 9210-9218, 2006.
10. Han GS, Carman GM. Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms. J Biol Chem 285: 14628-14638, 2010.
11. Harman-Boehm I, Blüher M, Redel H, Sion-Vardy N, Ovadia S, Avinoach E, Shai I, Klöting N, Stumvoll M, Bashan N, Rudich A. Macrophage infiltration into omental versus subcutaneous fat across different populations: effects of regional adiposity and the co-morbidities of obesity. J Clin Endocrinol Metab 92: 2240-2247, 2007.
12. Harris TE, Huffman TA, Chi A, Shabanowitz J, Hunt DF, Kumar A, Lawrence JC. Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. J Biol Chem 282: 277-286, 2007. (Pubitemid 47076630)
13. Higashida K, Higuchi M, Terada S. Potential role of lipin-1 in exercise-induced mitochondrial biogenesis. Biochem Biophys Res Commun 374: 587-591, 2008.
14. Hotamisligil GS. Inflammation and metabolic disorders. Nature 444: 860-867, 2006.
15. Koh YK, Lee MY, Kim JW, Kim M, Moon JS, Lee YJ, Ahn YH, Kim KS. Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2. J Biol Chem 283: 34896-34906, 2008.
16. Lebovitz HE, Banerji MA. Point: visceral adiposity is causally related to insulin resistance. Diabetes Care 28: 2322-2325, 2005.
17. Lu B, Lu Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 295: E1502-E1509, 2008.
18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
19. Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet 3: e64, 2007.
20. Miranda M, Chacón MR, Gómez J, Megía A, Ceperuelo-Mallafré V, Veloso S, Saumoy M, Gallart L, Richart C, Fernández-Real JM, Vendrell J; Adipocyte Differentiation Study Group. Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus-associated lipodystrophy syndrome. Metabolism 56: 1518-1526, 2007.
21. Miranda M, Escoté X, Ceperuelo-Mallafré V, Megía A, Caubet E, Näf S, Gómez JM, González-Clemente JM, Vicente V, Vendrell J. Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue. Int J Obes (Lond) 34: 679-686, 2010.
22. Newell FS, Su H, Tornqvist H, Whitehead JP, Prins JB, Hutley LJ. Characterization of the transcriptional and functional effects of fibroblast growth factor-1 on human preadipocyte differentiation. FASEB J 20: 2615-2617, 2006.
23. Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE. The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle. Endocrinology 149: 2853-2865, 2008.
24. Péterfy M, Phan J, Reue K. Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis. J Biol Chem 280: 32883-32889, 2005. (Pubitemid 41368337)
25. Phan J, Péterfy M, Reue K. Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. J Biol Chem 279: 29558-29564, 2004.
26. Phan J, Reue K. Lipin, a lipodystrophy and obesity gene. Cell Metab 1: 73-83, 2005.
27. Reue K, Dwyer JR. Lipin proteins and metabolic homeostasis. J Lipid Res 50: S109-S114, 2009.
28. Reue K, Zhang P. The lipin protein family: dual roles in lipid biosynthesis and gene expression. FEBS Lett 582: 90-96, 2008.
29. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444: 847-853, 2006. (Pubitemid 46024991)
30. Sharma AM, Staels B. Review: Peroxisome proliferator-activated receptor gamma and adipose tissue- understanding obesity-related changes in regulation of lipid and glucose metabolism. J Clin Endocrinol Metab 92: 386-395, 2007.
31. Suviolahti E, Reue K, Cantor RM, Phan J, Gentile M, Naukkarinen J, Soro-Paavonen A, Oksanen L, Kaprio J, Rissanen A, Salomaa V, Kontula K, Taskinen MR, Pajukanta P, Peltonen L. Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism. Hum Mol Genet 15: 377-386, 2006.
32. Tchkonia T, Tchoukalova YD, Giorgadze N, Pirtskhalava T, Karagiannides I, Forse RA, Koo A, Stevenson M, Chinnappan D, Cartwright A, Jensen MD, Kirkland JL. Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots. Am J Physiol Endocrinol Metab 288: E267-E277, 2005.
33. Tchoukalova Y, Koutsari C, Jensen M. Committed subcutaneous preadipocytes are reduced in human obesity. Diabetologia 50: 151-157, 2005. (Pubitemid 46035863)
34. Thirone AC, JeBailey L, Bilan PJ, Klip A. Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance. Diabetes 55: 942-951, 2006.
35. Tsuchiya Y, Takahashi N, Yoshizaki T, Tanno S, Ohhira M, Motomura W, Tanno S, Takakusaki K, Kohgo Y, Okumura T. A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes. Biochem Biophys Res Commun 382: 348-352, 2009.
36. van Harmelen V, Rydén M, Sjölin E, Hoffstedt J. A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression. J Lipid Res 48: 201-206, 2007.
37. Wabitsch M, Brenner RE, Melzner I, Braun M, Moller P, Heinze E, Debatin KM, Hauner H. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes 25: 8-15, 2001.
38. Waki H, Park KW, Mitro N, Pei L, Damoiseaux R, Wilpitz DC, Reue K, Saez E, Tontonoz P. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARγ expression. Cell Metab 5: 357-370, 2007.
39. Weaver RE, Donnelly D, Wabitsch M, Grant PJ, Balmforth AJ. Functional expression of glucose-dependent insulinotropic polypeptide receptors is coupled to differentiation in a human adipocyte model. Int J Obes 32: 1705-1711, 2008.
40. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 115: 1111-1119, 2005.
41. World Health Organization. Obesity: preventing and managing the global epidemic. In: WHO Technical Report Series 894. Geneva: World Health Organization, 2000.
42. Xu C, He J, Jiang H, Zu L, Zhai W, Pu S, Xu G. Direct effect of glucocorticoids on lipolysis in adipocytes. Mol Endocrinol 23: 1161-1170, 2009.
43. Yao-Borengasser A, Rasouli N, Varma V, Miles LM, Phanavanh B, Starks TN, Phan J, Spencer HJ 3rd, McGehee RE Jr, Reue K, Kern PA. Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes 55: 2811-2818, 2006.
44. Zhang P, O'Loughlin L, Brindley DN, Reue K. Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis. J Lipid Res 49: 1519-1528, 2008.