Outcomes in controlled and comparative studies on nonhealing wounds: Recommendations to improve the quality of evidence in wound management

Journal of Wound Care

Volumn 19, Issue 6, 2010, Pages 239-268

  Gottrup, F ^a   Apelqvist, J ^b,c   Price, P ^d  

^a BISPEBJERG HOSPITAL   (Denmark)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC DISEASE; CONFERENCE PAPER; CONSENSUS DEVELOPMENT; EUROPE; EVALUATION; EVIDENCE BASED PRACTICE; HEALTH CARE QUALITY; HUMAN; INFORMATION PROCESSING; INJURY; METHODOLOGY; RANDOMIZED CONTROLLED TRIAL; STANDARD;

CHRONIC DISEASE; DATA COLLECTION; EUROPE; EVALUATION STUDIES AS TOPIC; EVIDENCE-BASED PRACTICE; HUMANS; QUALITY INDICATORS, HEALTH CARE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; WOUNDS AND INJURIES;

EID: 77954905049     PISSN: 09690700     EISSN: None     Source Type: Journal    
DOI: 10.12968/jowc.2010.19.6.48471     Document Type: Article

References (137)

1. Abetz, L., Sutton, M., Brady, L. et al. The diabetic foot ulcer scale (DFS): a quality of life instrument for use in clinical trials. Practical Diabetes International 2002;19:6, 167-175.
2. Alvarez, O. M., Meehan, M., Ennis, W. et al. Palliative management for the frail population. Wounds 2002;14: (Suppl. 8):5S-27S.
3. Armstrong, D. G., Jude, E. B. The role of matrix metalloproteinases in wound healing. J Am Podiatr Med Assoc 2002;92:1, 12-18.
4. Armstrong, D. G., Lavery, L. A., Diabetic Foot Study Consortium. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet 2005;366:9498, 1704-1710.
5. Ashford, R. L., McGee, P., Kimmond, K. Perception of quality of life by patients with diabetic foot ulcers. The Diabetic Foot 2000;3:4, 150-155.
6. Bahmer, F. A. Wound measurement made truly simple by point counting. Arch Dermatol 1999;135:8, 991-992.
7. Bell-Syer, S., Brady, M., Bruce, J. et al. Letter: Evidence-based wound care in the UK: A response to David Leaper's editorial in International Wound Journal April 2009 6 (2).
8. Int Wound J 2009;6:4, 306-309.
9. Biancari, F., Salenius, J. P., Heikkinen, M. et al. Risk-scoring method for prediction of 30-day postoperative outcome after infrainguinal surgical revascularization for critical lower-limb ischemia: a Finnvasc registry study. World J Surg. 2007;31:1, 217-225.
10. Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clinical Pharmacol Ther 2001;69:3, 89-95.
11. Blume, P. A., Walters, J., Payne, W. et al. Comparison of negative pressure wound therapy using vacuumassisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial. Diabetes Care 2008;31:4, 631-636.
12. Boulton, A. J., Vileikyte, L., Ragnarson-Tennvall, G., Apelqvist, J. The global burden of diabetic foot disease. Lancet 2005;366:9498, 1719-1724.
13. Bulstrode, C. J., Goode, A. W., Scott, P. J. Measurement and prediction of progress in delayed wound healing. J R Soc Med 1987;80:4, 210-212.
14. Bouza, C., Munoz, A., Amata, J. M. Efficacy of modern dressings in the treatment of leg ulcers: a systematic review. Wound Repair Regen 2005;13:3, 218-229.
15. Brazier, J., Roberts, J., Deverill, M. The estimation of a preference-based measure of health from the SF-36. J Health Econ. 2002;21:2, 271-292.
16. Briggs, M., Closs, S. J. Patients' perceptions of the impact of treatments and products on their pain experience of leg ulcer pain. J Wound Care 2006;15:8, 333-337.
17. Cardinal, M., Eisenbud, D. E., Phillips, T., Harding, K. Early healing rates and wound area measurements are reliable predictors of later complete wound closure. Wound Repair Regen 2008;16:1, 19-22.
18. Carrington, A. L., Mawdsley, S. K., Morley, M. et al. Psychological status of diabetic people with or without lower limb disability. Diabetes Res Clin Pract 1996;32:1-2, 19-25.
19. Carrington, A. L., Mawdsley, S. K. V., Morely, M. et al. The psychological assessment of diabetic people with or without foot ulcers or lower limb amputations. In: Diabetic Neuropathy: New concepts and insights. Hotta N., Greene D. A., Ward J. D. et al. (eds). Elsevier Science, 1995.
20. Chaby, G., Senet, P., Veneau, M. et al. Dressings for acute and chronic wounds: a systematic review. Arch Dermatol 2007;143:10, 1297-1304. (Pubitemid 47607683)
21. The Cochrane Collaboration: www.cochrane.org/
22. Coerper, S., Beckert, S., Küper, M. A. et al. Fifty percent area reduction after 4 weeks of treatment is a reliable indicator for healing-analysis of a single-center cohort of 704 diabetic patients. J Diabetes Complications. 2009;23:1, 49-53.
23. Cole, J., Tsou, R., Wallace, K. et al. Early gene expression profile of human skin to injury using high-density cDNA microarrays. Wound Repair Regen 2001;9:5, 360-370. (Pubitemid 34038764)
24. Cooper, L., Johnson, C., Burslem, F., Martin, P. Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice. Genome Biol 2005;6:1, R5.
25. Cukjati, D., Rebersek, S., Karba, R., Miklavcic, D. Modelling of chronic wound healing dynamics. Med Biol Eng Comput 2000;38:3, 339-347.
26. Dale, J. J., Callam, M. J., Ruckley, C. V. et al. Chronic ulcers of the leg: a study of prevalence in a Scottish community. Health Bull 1983;41:6, 310-314.
27. De Gruttola, V. G., Clax, P., DeMets, D. L. et al. Considerations in the evaluation of surrogate endpoints in clinical trials. Summary of a National Institutes of Health workshop. Control Clin Trials 2001;22:5, 485-502.
28. Drummond, M. F., Sculpher, M. J., Torrance, G. W. et al. (eds). Methods for the Economic Evaluation of Health Care Programmes (3rd edn). Oxford University Press, 2005.
29. Edwards, R., Harding, K. G. Bacteria and wound healing. Curr Opin Infect Dis 2004;17:2, 91-96.
30. Eneroth, M., Larsson, J., Apelqvist, J. Foot infections in patients with diabetes and foot ulcer: an entity with different characteristics, treatments, and prognosis. J Diabetes Complications 1999;13:5-6, 254-263.
31. Eneroth, M., Larsson, J., Apelqvist, J. et al. The challenge of multicenter studies in diabetic patients with foot infections. The Foot 2004;14:4, 198-203.
32. Enoch, S., Price, P. E. Cellular, molecular and biochemical differences in the pathophysiology of healing between acute wounds, chronic wounds, and wounds in the aged. World Wide Wounds, 2004. http://www.worldwidewounds.com/ 2004/august/Enoch/Pathophysiology-Of-Healing.html
33. Enoch, S., Price, P. Should alternative endpoints be considered to evaluate outcomes in chronic recalcitrant wounds? World Wide Wounds, 2004. http://www.worldwidewounds.com/2004/october/Enoch-Part2/Alternative-Enpoints-To- Healing.html EuroQol group: www.euroqol.org
34. EWMA Position Documents: www.ewma.org/english/positiondocuments.html
35. Falanga, V., Saap, L. J., Ozonoff, A. Wound bed score and its correlation with healing of chronic wounds, Dermatol Ther 2006;19:6, 383-390.
36. Falanga, V. Classifications for wound bed preparation and stimulation of chronic wounds. Wound Repair Regen 2000;8:5, 347-352.
37. FDA: Guidance for industry: chronic cutaneous ulcer and burn wounds - developing products for treatment. Food and Drug Administration, June 2006. www.fda.gov/downloads/Drugs/GuidanceComp lianceR egulatory Information/ Guidances/ucm071324.pdf
38. Flanagan, M. Improving accuracy of wound measurement in clinical practice. Ostomy Wound Manage 2003;49:10, 28-40.
39. Fleck, C. A. Differentiating MMPs, biofilm, endotoxins, exotoxins, and cytokines. Adv Skin Wound Care 2006;19:2, 77-81.
40. Fleming, T. R., DeMets, D. L. Surrogate end points in clinical trials: are we being misled? Ann Intern Med 1996;125:7, 605-613.
41. Franks, P. J., McCullagh, L., Moffatt, C. J. Assessing quality of life in patients with chronic leg ulceration using the Medical Outcomes Short Form-36 questionnaire. Ostomy Wound Manage 2003;49:2, 26-37.
42. Franks, P. J., Moffatt, C. J. Health related quality of life in patients with venous ulceration: use of the Nottingham health profile. Qual Life Res 2001;10:8, 693-700.
43. Franks, P. J., Winterberg, H., Moffatt, C. J. Health-related quality of life and pressure ulceration assessment in patients treated in the community. Wound Repair Regen 2002;10:3, 133-140.
44. Franz, M. G., Kuhn, M. A., Wright, T. E. et al. Use of the wound healing trajectory as an outcome determinant for acute wound healing. Wound Repair Regen 2000;8:6, 511-516.
45. Freedman, L. S., Graubard, B. I., Schatzkin, A. Statistical validation of intermediate endpoints for chronic diseases. Stat Med 1992;11:2, 167-178.
46. Gebski, V., Marschner, I., Keech, A. C. Specifying objectives and outcomes for clinical trials. Med J Aust 2002;176:10, 491-492.
47. Gershater, M. A., Löndahl, M., Nyberg, P. et al. Complexity of factors related to outcome of neuropathic and neuroischaemic/ischaemic diabetic foot ulcers: a cohort study. Diabetologia 2009;52:3, 398-407.
48. Gethin, G., Cowman, S. Wound measurement comparing the use of acetate tracings and Visitrak digital planimetry. J Clin Nurs 2006;15:4, 422-427.
49. Gibran, N. S., Isik, F. F. Use of high-throughput microarray membranes for cDNA analysis of cutaneous wound repair. Methods Mol Med 2003;78:425-32.
50. Gorin, D. R., Cordts, P. R., LaMorte, W. W., Manzoian, J. O. The influence of wound geometry on the measurement of wound healing rates in clinical trials. J Vasc Surg 1996;23:3, 524-528.
51. Gottrup, F., Apelqvist, J. The challenge of using randomized trials in wound healing. Br J Surg 2010;97:3, 303-304.
52. Gottrup, F. A specialized wound-healing center concept: importance of a multidisciplinary department structure and surgical treatment facilities in the treatment of chronic wounds. Am J Surg 2004;187:5 A, 38S-43S.
53. Gottrup, F. Evidence is a challenge in wound management. Int J Low Extrem Wounds 2006;5:2, 74-75.
54. Gottrup, F. Evidence controversy in wound management. BMJ Rapid Response, 2009. http://www.bmj.com/cgi/eletters/335/7613/244191410
55. Gottrup, F. The EWMA Patient Outcome Group. J Wound Care 2009;18:11, 460.
56. Gottrup, F. Guest Editorial. EWMA J 2010;10:1, 3.
57. Grey, J. E., Leaper, D., Harding, K. How to measure success in treating chronic leg ulcers (editorial). Br Med J 2009;338: b1434.
58. Grose, R. Common ground in the tr0anscriptional profiles of wounds and tumors. Genome Biol 2004;5:6, 228.
59. Haghpanah, S., Bogie, K., Wang, X. et al. Reliability of electronic versus manual wound measurement techniques. Arch Phys Med Rehabil 2006;87:10, 1396-1402.
60. Hayward, P. G., Hillman, G. R., Quast, M. J., Robson, M. C. Surface area measurement of pressure sores using wound molds and computerized imaging. J Am Geriatr Soc 1993;41:3, 238-240.
61. Hinchliffe, R. J., Valk, G. D., Apelqvist, J. et al. A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes. Diabetes Metab Res Rev 2008;24: (Suppl. 1): S119-S144.
62. Horkan, L., Stansfield, G., Miller, M. An analysis of systematic reviews undertaken on standard advanced wound dressings in the last 10 years. J Wound Care 2009;18:7, 298-304.
63. Hyde, C., Ward, B., Horsfall, J., Winder, G. Older women's experience of living with chronic leg ulceration. Int J Nurs Pract 1999;5:4, 189-198.
64. Hyland, M. E., Ley, A., Thomson, B. Quality of life of leg ulcer patients: questionnaire and preliminary findings. J Wound Care 1994;3:294-98.
65. International Working Group on the Diabetic Foot (IWGDF). International consensus on the diabetic foot and practical guidelines on the management and prevention of the diabetic foot. IWGDF, 2007.
66. Jeffcoate, W. J., Price, P. E., Phillips, C. J. et al. Randomised controlled trial of the use of three dressing preparations in the management of chronic ulceration of the foot in diabetes. Health Technol Assess 2009;13:54, 1-86, iii-iv.
67. Keast, D. H., Bowering, C. K., Evans, A. W. et al. MEASURE: A proposed assessment framework for developing best practice recommendations for wound assessment. Wound Repair Regen 2004;12: (Suppl. 3), S1-17.
68. Kechagias, A., Perälä, J., Ylönen, K. et al. Validation of the Finnvasc score in infrainguinal percutaneous transluminal angioplasty for critical lower limb ischemia. Ann Vasc Surg 2008;22:4, 547-551.
69. Körber, A., Rietkötter, J., Grabbe, S., Dissemond, J. Three-dimensional documentation of wound healing: first results of a new objective method for measurement. J Dtsch Dermatol Ges 2006;4:10, 848-854.
70. Krasner, D. Painful venous ulcers: themes and stories about their impact on quality of life. Ostomy Wound Manage 1998;44:9, 38-42, 44, 46.
71. Leaper, D. Evidence-based wound care in the UK. Int Wound J 2009;6:2, 89-91.
72. Lagan, K. M., Dusoir, A. E., McDonough, S. M., Baxter, G. D. Wound measurement: the comparative reliability of direct versus photographic tracings analyzed by planimetry versus digitizing techniques. Arch Phys Med Rehabil 2000;81:8, 1110-1116.
73. Langemo, D. K., Melland, H., Hanson, D. et al. Two-dimensional wound measurement: comparison of 4 techniques. Adv Wound Care 1998;11:7, 337-343.
74. Lavery, L. A., Higgins, K. R., Lanctot, D. R. et al. Preventing diabetic foot ulcer recurrence in high-risk patients: use of temperature monitoring as a selfassessment tool. Diabetes Care 2007;30:1, 14-20.
75. Lazareth, I., Meaume, S., Sigal-Grinberg, L. et al. The role of a silver releasing l ipido-colloid contact layer in venous leg ulcers presenting inflammatory signs suggesting heavy bacterial colonization: results of a randomized controlled study. Wounds. 2008;20:6, 158-166.
76. Lazarus, G. S., Cooper, D. M., Knighton, D. R. et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol 1994;130:4, 489-493.
77. Levine, S., Nass, P., Rogstad, T. Effectiveness Guidance Document: Methodological Guidance for the Design of Comparative Effectiveness Studies, Devices for Local Treatment of Chronic Wounds (version 1.0). Center for Medical Technology Policy, 2009.
78. Lindholm, C., Bjellerup, M., Christensen, O. B., Zederfeldt, B. Quality of life in chronic leg ulcer patients: an assessment according to the Nottingham Health Profile. Acta Derm Venereol 1993;73:6, 440-443.
79. Lipsky, B. A., Giordano, P., Choudhri, S., Song, J. Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/amoxicillin-clavulanate. J Antimicrob Chemother 2007;60:2, 370-376.
80. Lipsky, B. A., Polis, A. B., Lantz, K. C. et al. The value of a wound score for diabetic foot infections in predicting treatment outcome: a prospective analysis from the SIDESTEP trial. Wound Repair Regen 2009;17:5, 671-677.
81. Little, C., McDonald, J., Jenkins, M. G., McCarron, P. An overview of techniques used to measure wound area and volume. J Wound Care 2009;18:6, 250-253.
82. Liu, P. Y., Eriksson, E., Mustoe, T. A. Wound healing: practical aspects. In: Russels, R. C. (ed). PSEF Instructial Courses. Mosby, 1991.
83. Lobmann, R., Ambrosch, A., Schultz, G. et al. Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients. Diabetologia 2002;45:7, 1011-1016.
84. Margolis, D. J., Gross, E. A., Wood, C. R., Lazarus, G. S. Planimetric rate of healing in venous ulcers of the leg treated with pressure bandage and hydrocolloid dressing. J Am Acad Dermatol 1993;28:3, 418-421.
85. Matousek, S., Deva, A. K., Mani, R. Outcome measurements in wound healing are not inclusive: a way forward. Int J Low Extrem Wounds 2007;6:4, 284-290.
86. Meaume, S., Vallet, D., Morere, M. N., Téot, L. Evaluation of a silverreleasing hydroalginate dressing in chronic wounds with signs of local infection. J Wound Care 2005;14:9, 411-419.
87. Meijer, J. W., Trip, J., Jaegers, S. M. et al. Quality of life in patients with diabetic foot ulcers. Disabil Rehabil 2001;23:8, 336-340.
88. Michaels, J. A., Campbell, B., King, B. et al. Randomized controlled trial and cost-effectivness analysis of silver-donating antimicrobial dressings for venous leg ulcers (VULCAN trial). Br J Surg 2009;96:10, 1147-1156.
89. Moher, D., Schulz, K. F., Altman, D. G. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 2001;357:9263, 1191-1194. (Pubitemid 32378696)
90. Moore, K., McCallion, R., Searle, R. J. et al. Prediction and monitoring the therapeutic response of chronic dermal wounds. Int Wound J 2006;3:2, 89-96.
91. Moore, K. Using wound area measurement to predict and monitor response to treatment of chronic wounds. J Wound Care 2005;14:5, 229-232.
92. Moses, M. A., Marikovsky, M., Harper, J. W. et al. Temporal study of the activity of matrix metalloproteinases and their endogenous inhibitors during wound healing. J Cell Biochem 1996;60:3, 379-386.
93. Mwaura, B., Mahendran, B., Hynes, N. et al. The impact of differential expression of extracellular matrix metalloproteinase inducer, matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2 and PDGF-AA on the chronicity of venous leg ulcers. Eur J Vasc Endovasc Surg. 2006;31:3, 306-310.
94. NICE (National Institute for Health and Clinical Excellence, UK): www.guidance.nice.org.uk/
95. NPUAP-EPUAP Guidelines for pressure ulcer prevention and treatment. www.npuap.org/www.epuap.org/
96. O'Meara, S., Cullum, N. A., Nelson, E. A. Compression for venous leg ulcers. Cochrane Database Syst Rev 2009;1: CD000265.
97. Paddock, H. N., Schultz, G. S., Perrin, K. J. et al. Clinical assessment of silver-coated antimicrobial dressings on MMPs and cytokine levels in non-healing wounds. Annual meeting presentation. Wound Healing Society, Baltimore, MD, May 28-June 1 2002.
98. Palfreyman, S., Nelson, E. A., Michaels, J. A. Dressings for venous leg ulcers: systematic review and meta-analysis. BMJ 2007;335:7613, 244.
99. Partsch, H., Clark, M., Mosti, G. et al. Classification of compression bandages: practical aspects. Dermatol Surg 2008;34:5, 600-609.
100. Peinemann, F., McGauran, N., Sauerland, S., Lange S. Negative pressure wound therapy: potential publication bias caused by lack of access to unpublished study results data. BMC Med Res Methodol 2008;11:8, 4.
101. Penhallow, K. A review of studies that examine the impact of infection on the normal wound-healing process. J Wound Care. 2005;14:3, 123-126.
102. Persoon, A., Heinen, M. M., van der Vleuten, C. J., de Rooij, M. J. Leg ulcers: a review of their impact on daily life. J Clin Nurs 2004;13:3, 341-354.
103. Phillips, T., Stanton, B., Provan, A., Lew, R. A study of the impact of leg ulcers on quality of life: financial, social, and psychologic implications. J Am Acad Dermatol 1994;31:1, 49-53.
104. Phillips, T. J., Machado, F., Trout, R. et al. Prognostic indicators in venous ulcers. J Am Acad Dermatol 2000;43:4, 627-630.
105. Pitrou, I., Boutron, I., Ahmad, N., Ravaud, P. Reporting safety results in published reports of randomized controlled trials. Arch Intern Med 2009;169:19, 756-761.
106. Posnett, J., Gottrup, F., Lundgren, H., Saal, G. The resource impact of wounds on health-care providers in Europe. J Wound Care 2009;18:4, 154-161.
107. Prentice, R. L. Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med 1998;8:4, 431-440.
108. Price, P. E., Fagervik-Morton, H., Mudge, E. J. Dressing-related pain in patients with chronic wounds: an international perspective. Int Wound J 2008;5:2, 159-171.
109. Price, P. The challenge of outcome measures in chronic wounds. J Wound Care 1999;8:6, 306-308.
110. Price, P. E. Education, psychology and 'compliance'. Diabetes Metab Res Rev 2008;24: (Suppl. 1), S101-105.
111. Prompers L., Huijberts, M., Apelqvist, J. et al. Delivery of care to diabetic foot ulcer patients in daily practice: results of the EURODIALE study, a prospective cohort study. Diabet Med 2008;25:6, 700-707.
112. Prompers, L., Schaper, N., Apelqvist, J. et al. Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE study. Diabetologia 2008;51:5, 747-755.
113. Prompers, L., Huijberts, M., Apelqvist, J. et al. High prevalence of ischemia, infection and serious comorbitity in patients with diabetic foot disease in Europe. Baseline results from the EURODIALE study. Diabetologia 2007;50:1, 18-25.
114. Prompers, L., Huijbert, M., Apelqvist, J. et al. Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral artery disease. The EURODIALE study. Diabetologia 2008;51:5, 747-55.
115. Prompers, L., Huijberts, M., Schaper, N. et al. Resource utilisation and costs associated with the treatment of diabetic foot ulcers. Prospective data from the EURODIALE study. Diabetologia 2008;51:10, 1826-1834.
116. Ragnarsson-Tennvall, G., Apelqvist, J. Cost-effective management of diabetic foot ulcers: a review. Pharmacoeconomics 1997;12:1, 42-53.
117. Ravanti, L., Kahari, V. M. Matrix metalloproteinases in wound repair. Int J Mol Med 2000;6:4, 391-407.
118. Robson, M. C., Dubay, D. A., Wang, X., Franz, M. G. Effect of cytokine growth factors on the prevention of acute wound failure. Wound Repair Regen 2004;12:1, 38-43.
119. Robson, M. C., Maggi, S. P., Smith, P. D. et al. Original articles: ease of wound closure as an endpoint of treatment efficacy. Wound Repair Regen 1999;7:2, 90-96.
120. Ryan, S., Eager, C., Sibbald, R. G. et al. Venous leg ulcer pain. Ostomy Wound Manage 2003;49: (Suppl. 4), 16-23.
121. Sackett, D. L., Rosenberg, W. M. C., Gray, J. A. M. Evidence-based medicine: what is and what isńt. BMJ 1996;312:7023, 71-72.
122. Schanzer, A., Goodney, P. P., Li, Y. et al. Validation of the PIII CLI risk score for the prediction of amputationfree survival in patients undergoing infrainguinal autogenous vein bypass for critical limb ischemia. J Vasc Surg 2009;50:4, 769-775.
123. Schanzer, A., Mega, J., Meadows, J. et al. Risk stratification in critical limb ischemia: derivation and validation of a model to predict amputation-free survival using multicenter surgical outcomes data. J Vasc Surg 2008;48:6, 1464-1471.
124. Schmutz, J. L., Meaume, S., Fays, S. et al. Evaluation of the nano-oligosaccharide factor lipido-colloid matrix in the local management of venous leg ulcers: results of a randomised, controlled trial. Int Wound J 2008;5:2, 172-182.
125. Sheehan, P., Jones, P., Caselli, A. et al. Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial. Plast Reconstr Surg 2006;117(Suppl. 7), 239S-244S.
126. Siebert, M., Clauss, L. C., Carlisle, M. et al. Health technology assessment for medical devices in Europe. What must be considered. Int J Technol Assess Health Care. 2002;18:3, 733-740.
127. Steed, D. L., Hill, D. P., Woodske, M. E. et al. Wound-healing trajectories as outcome measures of venous stasis ulcer treatment. Int Wound J. 2006;3:1, 40-47.
128. Svensjo, T., Yao, F., Pomahac, B. et al. Cultured autologous fibroblasts augment epidermal repair. Transplantation. 2002;73:7, 1033-1041.
129. Tallman, P., Muscare, E., Carson, P. et al. Initial rate of healing predicts complete healing of venous ulcers. Arch Dermatol 1997;133:10, 1231-1234.
130. Tarlton, J. F., Bailey, A. J., Crawford, E. et al. Prognostic value of markers of collagen remodeling in venous ulcers. Wound Repair Regen. 1999;7:5, 347-355.
131. Vaneau, M., Chaby, G., Guillot, B. et al. Consensus panel recommendations for chronic and acute wound dressing. Arch Dermatol. 2007;143:10, 1291-1294.
132. Vowden, K. Common problems in wound care: wound and ulcer measurement. Br J Nurs. 1995;4:13, 775-776.
133. Vuerstaek, J., Vainas, T., Wuite, J. et al. State-of-theart treatment of chronic leg ulcers: a randomized controlled trial comparing vacuum-assisted closure (V. A. C.) with modern wound dressings, J Vasc Surg. 2006;44:5, 1029-1038.
134. Walters, S. J., Morrell, C. J., Dixon, S. Measuring health-related quality of life in patients with venous leg ulcers. Qual Life Res. 1999;8:4, 327-336.
135. Williams, C. The Verge Videometer wound measurement package. Br J Nurs. 2000;9:4, 237-239.
136. Wissing, U., Ek, A. C., Unosson, M. Life situation and function in elderly people with and without leg ulcers. Scand J Caring Sci. 2002;6:1, 59-65.
137. Wolcott, R. D., Rhoads, D. D., Bennett, M. E. et al. Chronic wounds and the medical biofilm paradigm. J Wound Care. 2010;19:2, 45-53.