Plasma concentrations of salbutamol in the treatment of acute asthma in a pediatric emergency. Could age be a parameter of influence?

European Journal of Clinical Pharmacology

Volumn 66, Issue 6, 2010, Pages 605-610

  Rotta, Eloni T ^a   Amantéa, Sérgio L ^b,c,e   Froehlich, Pedro E ^d   Becker, Adriana ^c  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

^c HOSPITAL DA CRIANÇA SANTO ANTÔNIO   (Brazil)

^d FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^e NONE   (Brazil)

Author keywords

Acute asthma; Children; Emergency; Plasma concentrations; Salbutamol

Indexed keywords

AEROLIN SPRAY; FLUMAX BABY; SALBUTAMOL; UNCLASSIFIED DRUG; BRONCHODILATING AGENT;

AEROSOL; AGE DISTRIBUTION; ARTICLE; ASTHMA; BODY WEIGHT; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; FEMALE; HUMAN; MALE; NEBULIZATION; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; ACUTE DISEASE; ADOLESCENT; AGE; BLOOD; DRUG ADMINISTRATION; EMERGENCY HEALTH SERVICE; EMERGENCY TREATMENT; EPIDEMIOLOGY; HOSPITALIZATION; INFANT; INHALATIONAL DRUG ADMINISTRATION; METHODOLOGY; NEBULIZER;

ACUTE DISEASE; ADMINISTRATION, INHALATION; ADOLESCENT; AGE FACTORS; ALBUTEROL; ASTHMA; BODY WEIGHT; BRONCHODILATOR AGENTS; CHILD; CHILD, PRESCHOOL; CONFOUNDING FACTORS (EPIDEMIOLOGY); DRUG ADMINISTRATION SCHEDULE; EMERGENCY SERVICE, HOSPITAL; EMERGENCY TREATMENT; FEMALE; HUMANS; INFANT; MALE; NEBULIZERS AND VAPORIZERS; SEVERITY OF ILLNESS INDEX;

EID: 77954900594     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-010-0787-4     Document Type: Article

References (22)

1. Rubilar L, Rodriguez-Castro JA, Girardi G (2000) Randomized trial of salbutamol via metered-dose inhaler with spacer versus nebulizer for acute wheezing in children less than 2 years of age. Pediatric Pulmonol 29:264-269
2. Benedito-Fernández J et al (2004) Salbutamol via metered-dose inhaler with spacer versus nebulization for acute treatment of pediatric asthma in the emergency department. Pediatric Emerg Care 20:656-659
3. Amirav I, Newhouse MT (1997) Metered-dose inhaler accessory devices in acute asthma. Arch Pediatr Adolesc Med 151:876-882
4. Amantéa SL et al (2002) Controvérsias no manejo farmacológico da asma aguda infantil. J Pediatr (Rio J) 78(Supl.2):S151-S160
5. Lipworth BJ, Clark DJ (1997) Effects of airway calibre on lung delivery of nebulised salbutamol. Thorax 52:1036-1039
6. Closa RM, Ceballos JM, Gomez-Papí A et al (1998) Efficacy of bronchodilators administered by nebulizers versus spacer devices in infants with acute wheezing. Pediatric Pulmonol 26:344-348
7. Isler FA, Newth CJL (1995) Management of acute asthma in children. Baillieres Clin Paediatr 3:341-378
8. Reinhardt D et al (1984) Age-dependency of alpha and betaadrenoceptors on thrombocytes and lymphocytes of asthmatic and nonasthmatic children. Eur J Pediatr 142:111-116
9. Browne GJ et al (1997) Randomized trial of intravenous salbutamol in early management of acute severe asthma in children. Lancet 49:301-305
10. Global Initiative for Asthma (GINA) (2009) Pocket guide for asthma management and prevention in children 5 years and younger. http://www.ginasthma. org
11. Rotta ET, Amantéa SL, Froehlich PE, Becker A (2007) Determining salbutamol plasma concentrations after nebulization in pediatric emergency department. J Ped (RioJ) 83(5):481-484
12. Hutchings MJ, Paull JD, Morgan DJ (1983) Determination of salbutamol in plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 277:423-426
13. Penna AC et al (1993) Systemic absorption of salbutamol following nebulizer delivery in acute asthma. Acta Paediatr 82:963-966
14. Schuh S, Reider MJ, Canny G et al (1990) Nebulized albuterol in acute childhood asthma: comparison of two doses. Pediatrics 86:509-513
15. Kerem E et al (1993) Efficacy of albuterol administered by nebulizer versus spacer device in children with acute asthma. Pediatr Pharmacol Ther 123:313-317
16. Cates CJ et al (2006) Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma. Cochrane Database Syst Rev. doi:10.1002/14651858.CD000052.pub2
17. Deerojanawong J et al (2005) Randomized controlled trial of salbutamol aerosol therapy via metered dose inhaler-spacer vs jet nebulizer in young with children wheezing. Pediatr Pulmonol 39:466-472
18. Schuh S et al (1999) Comparison of albuterol delivered by a metered dose inhaler with spacer versus a nebulizer in children with mild acute asthma. J Pediatr 135:22-27
19. Ploin D et al (2000) High-dose albuterol by metered-dose inhaler plus a spacer device versus nebulization in preschool children with recurrent wheezing: a double-blind, randomized equivalence trial. Pediatrics 106:311-331
20. Delgado A et al (2003) Nebulizers vs metered-dose inhalers with spacers for bronchodilator therapy to treat wheezing in children aged 2 to 24 months in a pediatric emergency department. Arch Pediatric Adolesc Med 157:76-80
21. Bonnelykke K, Jespersen JJ, Bisgaard H (2007) Age dependent systemic esposure to inhaled salbutamol. Br J Clin Pharmacol 64:241-244
22. Lipworth B (1996) Pharmacokinetics of inhaled drugs. Br J Clin Pharmacol 42:697-705