Intracellular ATP depletion leads to reduced platinum accumulation in ovarian cancer cells

International Journal of Clinical Pharmacology and Therapeutics

Volumn 48, Issue 7, 2010, Pages 456-458

  Schneider, V ^a   Kalayda, G V ^a   Krieger, M L ^a   Bendas, G ^a   Jaehde, U ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Accumulation; ATP; Cisplatin; Oligomycin; Resistance

Indexed keywords

ADENOSINE TRIPHOSPHATE; CISPLATIN; OLIGOMYCIN;

ATOMIC ABSORPTION SPECTROMETRY; BIOLUMINESCENCE; CANCER CELL CULTURE; CELL ASSAY; CENTRIFUGATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG ACCUMULATION; DRUG TRANSPORT; DRUG UPTAKE; FEMALE; HUMAN; HUMAN CELL; OVARY CANCER; PROTEIN DEPLETION;

EID: 77954892924     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP48456     Document Type: Conference Paper

References (7)

1. Hall MD, Okabe M, Shen DW, Liang XJ, Gottesman MM. The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy. Annu Rev Pharmacol Toxicol. 2008; 48: 18.1-18.41.
2. Hatta Y, Takahashi M, Enomoto Y, Takahashi N, Sawada U, Horie T. Adenosine triphosphate (ATP) enhances the antitumor effect of etoposide (VP16) in lung cancer cells. Oncol Rep. 2004; 12: 1139-1142.
3. Rotte A, Garmann D, Buss I, Jaehde U. Effect of extracellular ATP on cisplatin-induced cytotoxicity in human ovarian carcinoma cells. Chemotherapy. 2010; 56: 1-8.
4. Watabe M, Nakaki T. ATP depletion does not account for apoptosis induced by inhibition of mitochondrial electron transport chain in human dopaminergic cells. Neuropharmacology. 2007; 52: 536-541. (Pubitemid 46123370)
5. Crouch SPM, Kozlowski R, Slater KJ, Fletcher J. The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity. J Immunol Methods. 1993; 160: 81-88. (Pubitemid 23085118)
6. Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res. 1988; 48: 589-601. (Pubitemid 18056527)
7. Zisowsky J, Koegel S, Leyers S, Devarakonda K, Kassack U, Osmak M, Jaehde U. Relevance of drug uptake and efflux for cisplatin sensitivity of tumor cells. Biochem Pharmacol. 2007; 73: 298-307. (Pubitemid 44855730)