Application of LC-NMR and HR-NMR to the characterization of biphenyl impurities in the synthetic route development for vestipitant, a novel NK1 antagonist

Journal of Pharmaceutical and Biomedical Analysis

Volumn 53, Issue 3, 2010, Pages 389-395

  Provera, Stefano ^a   Martini, Luca ^a   Guercio, Giuseppe ^a   Turco, Lucilla ^a   Costa, Laura ^a   Marchioro, Carla ^a  

^a GSK   (Italy)

Author keywords

19F NMR; 1H NMR; HPLC; LC NMR; Vestipitant

Indexed keywords

VESTIPITANT;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; DRUG IMPURITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINE NUCLEAR MAGNETIC RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH RESOLUTION NUCLEAR MAGNETIC RESONANCE; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

BIPHENYL COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; MAGNETIC RESONANCE SPECTROSCOPY; PIPERIDINES; RECEPTORS, NEUROKININ-1;

EID: 77954887715     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.04.027     Document Type: Article

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