New secoiridoid glucosides from ligustrum lucidum induce erk and creb phosphorylation in cultured cortical neurons

Planta Medica

Volumn 76, Issue 10, 2010, Pages 998-1003

  Fu, Guangmiao ^a   Ip, Fanny C F ^a   Pang, Haihong ^a   Ip, Nancy Y ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

CREB; ERK; isooleonuezhenide; Ligustrum lucidum; methyloleoside 7ethyl ester; Oleaceae; secoiridoid glucosides

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; G 13; ISO OLEONUEZHENIDE; JASPOLYSIDE METHYL ESTER; LIGUSTRUM LUCIDUM EXTRACT; METHYLOLEOSIDE 7 ETHYL ESTER; MITOGEN ACTIVATED PROTEIN KINASE; NUEZHENIDE; OLEONUEZHENIDE; OLEUROPEIN; SECOIRIDOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CARBON NUCLEAR MAGNETIC RESONANCE; DOSE RESPONSE; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SPRAGUE DAWLEY RAT; THIN LAYER CHROMATOGRAPHY; WESTERN BLOTTING;

ANIMALS; BRAIN; CELL CULTURE TECHNIQUES; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FRUIT; IRIDOID GLUCOSIDES; LIGUSTRUM; MOLECULAR STRUCTURE; NEURONS; PHOSPHORYLATION; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

LIGUSTRUM LUCIDUM; OLEACEAE;

EID: 77954881831     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1240869     Document Type: Article

References (25)

1. Carlezon Jr W A., Duman R S., Nestler E J. The many faces of CREB. Trends Neurosci 2005 28 436-445
2. Shaywitz A J., Greenberg M E. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 1999 68 821-861
3. Grewal S S., York R D., Stork P J. Extracellular-signal-regulated kinase signalling in neurons. Curr Opin Neurobiol 1999 9 544-553
4. Hong E J., West A E., Greenberg M E. Transcriptional control of cognitive development. Curr Opin Neurobiol 2005 15 21-28
5. Xia M, Huang R, Guo V, Southall N, Cho M H., Inglese J, Austin C P., Nirenberg M. Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory. Proc Natl Acad Sci USA 2009 106 2412-2417
6. Pharmacopoeia Committee of China. Chinese Pharmacopoeia (Part A). Beijing The Technology Publishing House 2005 31-32
7. Jiangsu New College of Medicine. The dictionary of Chinese medicine. Shanghai Shanghai People's Press 1977 237-239
8. Wu L J., Xiang T, Hou B L., Liang W, Yi S, Zhou X C. Chemical constituents from fruits of Ligustrum lucidum. Acta Bot Sin 1998 40 88-92
9. Xu X H., Yang N Y., Qian S H., Xie N, Yu M Y., Duan J A. Study on flavonoids on Ligustrum lucidum. J Chin Med Mater 2007 30 538-539
10. Zhang X H., Shi L F. Studies on chemical constituents of Fructus Ligustri lucidi(I). Acad J Sec Milit Med Univ 2004 25 333-334
11. Shi L F., Cao Y Y., Chen H S., Dong J P. Isolation and identification of two new secoiridoids of water-soluble chemical constituents from the fruits of Ligustrum lucidum Ait. Acta Pharm Sin 1997 32 442-446
12. He Z D., Dong H, Xu H X., Ye W C., Sun H D., But P P. Secoiridoid constituents from the fruits of Ligustrum lucidum. Phytochemistry 2001 56 327-330 (Pubitemid 32179828)
13. He Z D., But P P., Chan T D., Dong H, Xu H X., Lau C P., Sun H D. Antioxidative glucosides from the fruits of Ligustrum lucidum. Chem Pharm Bull 2001 49 780-784 (Pubitemid 32587133)
14. Ma S C., He Z D., Deng X L., But P P., Ooi V E., Xu H X., Lee S H., Lee S F. In vitro evaluation of secoiridoid glucosides from the fruits of Ligustrum lucidum as antiviral agents. Chem Pharm Bull (Tokyo) 2001 49 1471-1473
15. Konno K, Hirayama C, Yasui H, Nakamura M. Enzymatic activation of oleuropein: a protein crosslinker used as a chemical defense in the privet tree. Proc Natl Acad Sci USA 1999 96 9159-9164
16. Sung S H., Kim E S., Lee K Y., Lee M K., Kim Y C. A new neuroprotective compound of Ligustrum japonicum leaves. Planta Med 2006 72 62-64
17. Fu W Y., Chen Y, Sahin M, Zhao X S., Shi L, Bikoff J B., Lai K O., Yung W H., Fu A K., Greenberg M E., Ip N Y. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci 2007 10 67-76
18. Yu J C., Min Z D., Ip N Y. Melia toosendan regulates PC12 cell differentiation via the activation of protein kinase A and extracellular signal-regulated kinases. Neurosignals 2004 13 248-257
19. Lonze B E., Ginty D D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002 35 605-623
20. Fukuyama Y, Koshino K, Hasegawa T, Yamada T, Nakagawa K. New secoiridoid glucosides from Ligustrum japonicum. Planta Med 1987 53 427-431
21. Servili M, Baldioli M, Selvaggini R, Macchioni A, Montedoro G. Phenolic compounds of olive fruit: one- and two-dimensional nuclear magnetic resonance characterization of nuezhenide and its distribution in the constitutive parts of fruit. J Agric Food Chem 1999 47 12-18
22. Zhao G Q., Xia J J., Dong J X. Glycosides from flowers of Jasminum officinale L. var. grandiflorum. Acta Pharm Sin 2007 42 1066-1069
23. Shen Y C., Lin S L., Chein C C. Jaspolyside, a secoiridoid glycoside from Jasminum polyanthum. Phytochemistry 1996 42 1629-1631
24. El-Naggar L J., Beal J L. Iridoids. A review. J Nat Prod 1980 43 649-707
25. Wu M J., Zhao T Z., Zhang H Y., Yin W P., Fu J G. Studies on chemical constituents of Syringa pubescens (I). Chin Tradit Herb Drugs 2003 34 7-8