메뉴 건너뛰기




Volumn 36, Issue 5, 2010, Pages 510-521

Structure and function of a recombinant von willebrand factor drug candidate

Author keywords

hemophilia; platelet binding; Recombinant von Willebrand factor; structure; von Willebrand disease; VWD; VWF

Indexed keywords

COLLAGEN; MATRIX PROTEIN; RECOMBINANT PROTEIN; RECOMBINANT VON WILLEBRAND FACTOR; RISTOCETIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

EID: 77954877699     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0030-1255445     Document Type: Review
Times cited : (52)

References (41)
  • 1
    • 17944364717 scopus 로고    scopus 로고
    • Recombinant von Willebrand factor: Preclinical development
    • Plaimauer B, Schlokat U, Turecek P L. et al. Recombinant von Willebrand factor: preclinical development. Semin Thromb Hemost 2001 27 (4) 395-403
    • (2001) Semin Thromb Hemost , vol.27 , Issue.4 , pp. 395-403
    • Plaimauer, B.1    Schlokat, U.2    Turecek, P.L.3
  • 2
    • 0035746912 scopus 로고    scopus 로고
    • Von Willebrand factor and von Willebrand disease
    • Budde U, Schneppenheim R. Von Willebrand factor and von Willebrand disease. Rev Clin Exp Hematol 2001 5 (4) 335-368
    • (2001) Rev Clin Exp Hematol , vol.5 , Issue.4 , pp. 335-368
    • Budde, U.1    Schneppenheim, R.2
  • 3
    • 67849097380 scopus 로고    scopus 로고
    • Von Willebrand factor assembly and secretion
    • Sadler J E. von Willebrand factor assembly and secretion. J Thromb Haemost 2009 7 (Suppl 1) 24-27
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. 1 , pp. 24-27
    • Sadler, J.E.1
  • 4
    • 34249889864 scopus 로고    scopus 로고
    • The role of von Willebrand factor in thrombus formation
    • Ruggeri Z M. The role of von Willebrand factor in thrombus formation. Thromb Res 2007 120 (Suppl 1) S5-S9
    • (2007) Thromb Res , vol.120 , Issue.SUPPL. 1
    • Ruggeri, Z.M.1
  • 5
    • 53549094680 scopus 로고    scopus 로고
    • VWF attributesimpact on thrombus formation
    • Reininger A J. VWF attributesimpact on thrombus formation. Thromb Res 2008 122 (Suppl 4) S9-S13
    • (2008) Thromb Res , vol.122 , Issue.SUPPL. 4
    • Reininger, A.J.1
  • 6
    • 51349164922 scopus 로고    scopus 로고
    • Function of von Willebrand factor in haemostasis and thrombosis
    • Reininger A J. Function of von Willebrand factor in haemostasis and thrombosis. Haemophilia 2008 14 (Suppl 5) 11-26
    • (2008) Haemophilia , vol.14 , Issue.SUPPL. 5 , pp. 11-26
    • Reininger, A.J.1
  • 7
    • 0031686041 scopus 로고    scopus 로고
    • Biochemistry and genetics of von Willebrand factor
    • Sadler J E. Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem 1998 67 395-424
    • (1998) Annu Rev Biochem , vol.67 , pp. 395-424
    • Sadler, J.E.1
  • 9
    • 0028825737 scopus 로고
    • Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets
    • Goto S, Salomon D R., Ikeda Y, Ruggeri Z M. Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets. J Biol Chem 1995 270 (40) 23352-23361
    • (1995) J Biol Chem , vol.270 , Issue.40 , pp. 23352-23361
    • Goto, S.1    Salomon, D.R.2    Ikeda, Y.3    Ruggeri, Z.M.4
  • 10
    • 0032402122 scopus 로고    scopus 로고
    • The life cycle of coagulation factor VIII in view of its structure and function
    • Lenting P J., van Mourik J A., Mertens K. The life cycle of coagulation factor VIII in view of its structure and function. Blood 1998 92 (11) 3983-3996
    • (1998) Blood , vol.92 , Issue.11 , pp. 3983-3996
    • Lenting, P.J.1    Van Mourik, J.A.2    Mertens, K.3
  • 11
    • 0017754787 scopus 로고
    • Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease
    • Weiss H J., Sussman I I., Hoyer L W. Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease. J Clin Invest 1977 60 (2) 390-404
    • (1977) J Clin Invest , vol.60 , Issue.2 , pp. 390-404
    • Weiss, H.J.1    Sussman, I.I.2    Hoyer, L.W.3
  • 13
    • 0032705572 scopus 로고    scopus 로고
    • Recombinant von Willebrand factor: Potential therapeutic use
    • Fischer B E. Recombinant von Willebrand factor: potential therapeutic use. J Thromb Thrombolysis 1999 8 (3) 197-205
    • (1999) J Thromb Thrombolysis , vol.8 , Issue.3 , pp. 197-205
    • Fischer, B.E.1
  • 14
    • 75549090170 scopus 로고    scopus 로고
    • Development of a plasma- and albumin-free recombinant von Willebrand factor
    • Turecek P L., Mitterer A, Matthiessen H P. et al. Development of a plasma- and albumin-free recombinant von Willebrand factor. Hamostaseologie 2009 29 (Suppl 1) S32-S38
    • (2009) Hamostaseologie , vol.29 , Issue.SUPPL. 1
    • Turecek, P.L.1    Mitterer, A.2    Matthiessen, H.P.3
  • 15
    • 47649131839 scopus 로고    scopus 로고
    • Plasma and albumin-free recombinant factor VIII: Pharmacokinetics, efficacy and safety in previously treated pediatric patients
    • rAHF-PFM Clinical Study Group
    • Blanchette V S., Shapiro A D., Liesner R J. et al, rAHF-PFM Clinical Study Group. Plasma and albumin-free recombinant factor VIII: pharmacokinetics, efficacy and safety in previously treated pediatric patients. J Thromb Haemost 2008 6 (8) 1319-1326
    • (2008) J Thromb Haemost , vol.6 , Issue.8 , pp. 1319-1326
    • Blanchette, V.S.1    Shapiro, A.D.2    Liesner, R.J.3
  • 16
    • 0022999369 scopus 로고
    • Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains
    • Fretto L J., Fowler W E., McCaslin D R., Erickson H P., McKee P A. Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains. J Biol Chem 1986 261 (33) 15679-15689
    • (1986) J Biol Chem , vol.261 , Issue.33 , pp. 15679-15689
    • Fretto, L.J.1    Fowler, W.E.2    McCaslin, D.R.3    Erickson, H.P.4    McKee, P.A.5
  • 17
    • 0020407701 scopus 로고
    • Electron microscopy of human factor VIII/Von Willebrand glycoprotein: Effect of reducing reagents on structure and function
    • Ohmori K, Fretto L J., Harrison R L., Switzer M E., Erickson H P., McKee P A. Electron microscopy of human factor VIII/Von Willebrand glycoprotein: effect of reducing reagents on structure and function. J Cell Biol 1982 95 (2 Pt 1) 632-640
    • (1982) J Cell Biol , vol.95 , Issue.2 PART 1 , pp. 632-640
    • Ohmori, K.1    Fretto, L.J.2    Harrison, R.L.3    Switzer, M.E.4    Erickson, H.P.5    McKee, P.A.6
  • 18
    • 0019442145 scopus 로고
    • The complex multimeric composition of factor VIII/von Willebrand factor
    • Ruggeri Z M., Zimmerman T S. The complex multimeric composition of factor VIII/von Willebrand factor. Blood 1981 57 (6) 1140-1143
    • (1981) Blood , vol.57 , Issue.6 , pp. 1140-1143
    • Ruggeri, Z.M.1    Zimmerman, T.S.2
  • 19
    • 0022447177 scopus 로고
    • Visualization of von Willebrand factor multimers by immunoenzymatic stain using avidin-biotin peroxidase complex
    • Aihara M, Sawada Y, Ueno K et al. Visualization of von Willebrand factor multimers by immunoenzymatic stain using avidin-biotin peroxidase complex. Thromb Haemost 1986 55 (2) 263-267
    • (1986) Thromb Haemost , vol.55 , Issue.2 , pp. 263-267
    • Aihara, M.1    Sawada, Y.2    Ueno, K.3
  • 20
    • 47249144803 scopus 로고    scopus 로고
    • Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura
    • Sadler J E. Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura. Blood 2008 112 (1) 11-18
    • (2008) Blood , vol.112 , Issue.1 , pp. 11-18
    • Sadler, J.E.1
  • 21
    • 58149104511 scopus 로고    scopus 로고
    • Von Willebrand factor: Another janus-faced hemostasis protein
    • Franchini M, Mannucci P M. Von Willebrand factor: another janus-faced hemostasis protein. Semin Thromb Hemost 2008 34 (7) 663-669
    • (2008) Semin Thromb Hemost , vol.34 , Issue.7 , pp. 663-669
    • Franchini, M.1    Mannucci, P.M.2
  • 22
    • 0029925856 scopus 로고    scopus 로고
    • Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis
    • Furlan M, Robles R, Lämmle B. Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis. Blood 1996 87 (10) 4223-4234
    • (1996) Blood , vol.87 , Issue.10 , pp. 4223-4234
    • Furlan, M.1    Robles, R.2    Lämmle, B.3
  • 23
    • 67649458188 scopus 로고    scopus 로고
    • Species-dependent variability of ADAMTS13-mediated proteolysis of human recombinant von Willebrand factor
    • Varadi K, Rottensteiner H, Vejda S et al. Species-dependent variability of ADAMTS13-mediated proteolysis of human recombinant von Willebrand factor. J Thromb Haemost 2009 7 (7) 1134-1142
    • (2009) J Thromb Haemost , vol.7 , Issue.7 , pp. 1134-1142
    • Varadi, K.1    Rottensteiner, H.2    Vejda, S.3
  • 24
    • 0026442717 scopus 로고
    • Identification of aspartic acid 514 through glutamic acid 542 as a glycoprotein Ib-IX complex receptor recognition sequence in von Willebrand factor. Mechanism of modulation of von Willebrand factor by ristocetin and botrocetin
    • Berndt M C., Ward C M., Booth W J., Castaldi P A., Mazurov A V., Andrews R K. Identification of aspartic acid 514 through glutamic acid 542 as a glycoprotein Ib-IX complex receptor recognition sequence in von Willebrand factor. Mechanism of modulation of von Willebrand factor by ristocetin and botrocetin. Biochemistry 1992 31 (45) 11144-11151
    • (1992) Biochemistry , vol.31 , Issue.45 , pp. 11144-11151
    • Berndt, M.C.1    Ward, C.M.2    Booth, W.J.3    Castaldi, P.A.4    Mazurov, A.V.5    Andrews, R.K.6
  • 25
    • 27144461083 scopus 로고    scopus 로고
    • A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B
    • Hulstein J J., de Groot P G., Silence K, Veyradier A, Fijnheer R, Lenting P J. A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B. Blood 2005 106 (9) 3035-3042
    • (2005) Blood , vol.106 , Issue.9 , pp. 3035-3042
    • Hulstein, J.J.1    De Groot, P.G.2    Silence, K.3    Veyradier, A.4    Fijnheer, R.5    Lenting, P.J.6
  • 26
    • 0032528532 scopus 로고    scopus 로고
    • Binding of factor VIII to von Willebrand factor is enabled by cleavage of the von Willebrand factor propeptide and enhanced by formation of disulfide-linked multimers
    • Bendetowicz A V., Morris J A., Wise R J., Gilbert G E., Kaufman R J. Binding of factor VIII to von Willebrand factor is enabled by cleavage of the von Willebrand factor propeptide and enhanced by formation of disulfide-linked multimers. Blood 1998 92 (2) 529-538
    • (1998) Blood , vol.92 , Issue.2 , pp. 529-538
    • Bendetowicz, A.V.1    Morris, J.A.2    Wise, R.J.3    Gilbert, G.E.4    Kaufman, R.J.5
  • 27
    • 0029035099 scopus 로고
    • The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor
    • Vlot A J., Koppelman S J., Berg van den M H., Bouma B N., Sixma J J. The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor. Blood 1995 85 (11) 3150-3157
    • (1995) Blood , vol.85 , Issue.11 , pp. 3150-3157
    • Vlot, A.J.1    Koppelman, S.J.2    Berg Van Den, M.H.3    Bouma, B.N.4    Sixma, J.J.5
  • 28
    • 28344438894 scopus 로고    scopus 로고
    • Von Willebrand factor: Two sides of a coin
    • Sadler J E. von Willebrand factor: two sides of a coin. J Thromb Haemost 2005 3 (8) 1702-1709
    • (2005) J Thromb Haemost , vol.3 , Issue.8 , pp. 1702-1709
    • Sadler, J.E.1
  • 29
    • 60549104066 scopus 로고    scopus 로고
    • Clinical utility of the PFA-100
    • Favaloro E J. Clinical utility of the PFA-100. Semin Thromb Hemost 2008 34 (8) 709-733
    • (2008) Semin Thromb Hemost , vol.34 , Issue.8 , pp. 709-733
    • Favaloro, E.J.1
  • 30
    • 0035877749 scopus 로고    scopus 로고
    • Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib
    • Soslau G, Class R, Morgan D A. et al. Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib. J Biol Chem 2001 276 (24) 21173-21183
    • (2001) J Biol Chem , vol.276 , Issue.24 , pp. 21173-21183
    • Soslau, G.1    Class, R.2    Morgan, D.A.3
  • 31
    • 0024588409 scopus 로고
    • Measurements of platelet interaction with components of the vessel wall in flowing blood
    • Sakariassen K S., Muggli R, Baumgartner H R. Measurements of platelet interaction with components of the vessel wall in flowing blood. Methods Enzymol 1989 169 37-70
    • (1989) Methods Enzymol , vol.169 , pp. 37-70
    • Sakariassen, K.S.1    Muggli, R.2    Baumgartner, H.R.3
  • 32
    • 34250818668 scopus 로고    scopus 로고
    • Adhesion mechanisms in platelet function
    • Ruggeri Z M., Mendolicchio G L. Adhesion mechanisms in platelet function. Circ Res 2007 100 (12) 1673-1685
    • (2007) Circ Res , vol.100 , Issue.12 , pp. 1673-1685
    • Ruggeri, Z.M.1    Mendolicchio, G.L.2
  • 33
    • 3042576416 scopus 로고    scopus 로고
    • The factor VIII/von Willebrand factor complex: Basic and clinical issues
    • EREP02
    • Federici A B. The factor VIII/von Willebrand factor complex: basic and clinical issues. Haematologica 2003 88 (6) EREP02
    • (2003) Haematologica , vol.88 , Issue.6
    • Federici, A.B.1
  • 34
    • 0037015057 scopus 로고    scopus 로고
    • Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity
    • Kokame K, Matsumoto M, Soejima K et al. Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity. Proc Natl Acad Sci U S A 2002 99 (18) 11902-11907
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.18 , pp. 11902-11907
    • Kokame, K.1    Matsumoto, M.2    Soejima, K.3
  • 35
    • 0035807348 scopus 로고    scopus 로고
    • Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
    • Levy G G., Nichols W C., Lian E C. et al. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature 2001 413 (6855) 488-494
    • (2001) Nature , vol.413 , Issue.6855 , pp. 488-494
    • Levy, G.G.1    Nichols, W.C.2    Lian, E.C.3
  • 36
    • 0037111571 scopus 로고    scopus 로고
    • Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13)
    • Plaimauer B, Zimmermann K, Völkel D et al. Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13). Blood 2002 100 (10) 3626-3632
    • (2002) Blood , vol.100 , Issue.10 , pp. 3626-3632
    • Plaimauer, B.1    Zimmermann, K.2    Völkel, D.3
  • 37
    • 0345140606 scopus 로고    scopus 로고
    • Cleavage of recombinant von Willebrand Factor (vWF) by a vWF-depolymerizing protease
    • Abstract 1291
    • Turecek P L., Furlan M, Lämmle B et al. Cleavage of recombinant von Willebrand Factor (vWF) by a vWF-depolymerizing protease. Blood 1996 88 (Suppl 1) 326a Abstract 1291
    • (1996) Blood , vol.88 , Issue.SUPPL. 1
    • Turecek, P.L.1    Furlan, M.2    Lämmle, B.3
  • 38
    • 2342591992 scopus 로고    scopus 로고
    • A comparative in vitro evaluation of six von Willebrand factor concentrates
    • Lethagen S, Carlson M, Hillarp A. A comparative in vitro evaluation of six von Willebrand factor concentrates. Haemophilia 2004 10 (3) 243-249
    • (2004) Haemophilia , vol.10 , Issue.3 , pp. 243-249
    • Lethagen, S.1    Carlson, M.2    Hillarp, A.3
  • 39
    • 33749011946 scopus 로고    scopus 로고
    • Comparative analysis and classification of von Willebrand factor/factor VIII concentrates: Impact on treatment of patients with von Willebrand disease
    • Budde U, Metzner H J., Müller H G. Comparative analysis and classification of von Willebrand factor/factor VIII concentrates: impact on treatment of patients with von Willebrand disease. Semin Thromb Hemost 2006 32 (6) 626-635
    • (2006) Semin Thromb Hemost , vol.32 , Issue.6 , pp. 626-635
    • Budde, U.1    Metzner, H.J.2    Müller, H.G.3
  • 40
    • 33746623341 scopus 로고    scopus 로고
    • Von Willebrand factor standards for plasma and concentrate testing
    • Hubbard A R. von Willebrand factor standards for plasma and concentrate testing. Semin Thromb Hemost 2006 32 (5) 522-528
    • (2006) Semin Thromb Hemost , vol.32 , Issue.5 , pp. 522-528
    • Hubbard, A.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.