Protection by 3'-methoxypuerarin of rat hippocampal neurons against ischemia/reperfusion injury

Chinese Journal of Physiology

Volumn 53, Issue 2, 2010, Pages 136-140

  Liu, Yajun ^a   Chen, Xiaonan ^b   Liu, Kejing ^a   Chai, Qiang ^c   Li, Jingxin ^a   Liu, Zhixiang ^c   Sun, Dong ^d   Chen, Lianbi ^a,e  

^a SHANDONG UNIVERSITY   (China)

^b Affiliated Hospital   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^d Jinan Lixia Food and Drug Administration   (China)

^e Kevin Shandong Vocational College of Science and Technology   (China)

Author keywords

3' methoxypuerarin; Apoptosis; Hippocampal neurons; Ischemia reperfusion injury; Rat

Indexed keywords

3' METHOXYPUERARIN; ISOFLAVONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; RAT; REPERFUSION INJURY;

EID: 77954874738     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: 10.4077/CJP.2010.AMK029     Document Type: Article

References (17)

1. Chai, Q., Liu, Z.X., Zhao, A. and Chai, X. The effect of puerarin on calcium activated potassium channels of cerebral artery in rabbits. Chinese J. Neurosci. 17: S31, 2001.
2. Chen, L., Chai, Q., Wei, L. and Zhao, A. Effects of β-receptor blockers (puerarin and propranolol) on cerebral blood flow in dog. J. Cereb. Blood Flow Metab. 13: S186, 1993.
3. Chen, L., Chai, Q., Zhao, A. and Chai, X. Effect of puerarin on cerebral blood flow in dogs. ZhongguoZhong Yao Za Zhi 20: 560-564, 1995.
4. Chen, L., Chen, S. and Liu, Y. The research survey of puerarin in the resource, chemical constituents and pharmacological action. Shi Zhen Guo Yi Guo Yao 17: 2305-2306, 2006.
5. Han, J., Wan, H., Ge, L., Zhu, Z., Guo, Y., Zhang, Y. and Li, J. Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/reperfusion in rats. Zhongguo Zhong Yao Za Zhi 34: 14221425, 2009.
6. Hu, J. and Xu, D. The pharmacological and clinic research development of puerarin. World Clin. Drugs 27: 215-220, 2006.
7. Li, H. and Yu, G. The study on the extraction of isoflavones and edible products from puerarin. Food Res. Dev. 27: 104-106, 2006.
8. Liu, J., Chen, Q. and Hu, D. The identification of 3'-MOP from puerarin and puerarin preparations. Chinese Pharm. J. 38: 153156, 2003.
9. Liu, Y., Sercombe, R., Xie, D., Liu, K. and Chen, L. Inhibition of caspase-9 activation and apoptosis is involved in ischemic precon-ditioning-induced neuroprotection in rat brain. Neurol. Res. 29: 855-858, 2007.
10. Liu, Y., Wang, P.S., Xie, D., Liu, K. and Chen, L. Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chinese J. Physiol. 49: 244-250, 2006.
11. Meng, X. and Wan, H. The research and development of traditional chinese medicine in the protection against ischemia/reperfusion injury. J. Emerg. Tradit. Chin. Med. 13: 243-245, 2004.
12. Tian, Z., Yu, P. and Li, Z. The research and development of a chinese traditional medicine: puerarin. Chinese Med. J. 4: 879881, 2004.
13. Wang, W., Zhang, H. and Zhu, J. The prevention and therapeutic function of puerarin in SHRsp stroke. Chinese J. Hypertens. 8: 58-61, 2000.
14. Xu, X., Zhang, S., Zhang, L., Yan, W. and Zheng, X. The Neuro-protection of puerarin against cerebral ischemia is associated with the prevention of apoptosis in rats. Planta Med. 71: 585-591, 2005.
15. Ye, J., Zhou, X., Chen, Z. and Ye, W. Two dimensional nuclear magnetic resonance (NMR) study on the structure of natural 3'-MOP solution. Xiamen Da Xue Xue Bao Zi Ran Ke Xue Ban 42: 69-72, 2003.
16. Zhang, Y.B., Du, G.Y., Xiong, Y.L., Zhao, Y., Cui, H.F., Cao, C.Y. and Liu, S. Protective effects of 3'-methoxy-puerarin on rat brain suffering from ischemia. Zhongguo Zhong Yao Za Zhi 33: 537-540, 2008.
17. Zhao, T., Han, J., Chen, Y., Wan, H. and Bie, X. The mechanism of 3'-methoxy puerarin on decreasing the cerebral ischemia-reperfusion injury in rats. Asia Pac. J. Clin. Nutr. 16: 302-304, 2007.