Process modeling and optimization of batch fractional distillation to increase throughput and yield in manufacture of active pharmaceutical ingredient (API)

Computers and Chemical Engineering

Volumn 34, Issue 7, 2010, Pages 1030-1035

  Yang, Yubo ^a   Tjia, Rosalin ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Fractional batch distillation; Pharmaceutical API purification; Process modeling

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; BATCH DISTILLATION; COMMERCIAL PRODUCTIONS; CYCLE TIME; DRUG SUBSTANCES; ENGINEERING PRINCIPLES; FRACTIONAL DISTILLATION; HIGH PURITY; HIGH-QUALITY PRODUCTS; PACKED COLUMN; PROCESS IMPROVEMENT; PROCESS MODELING; PROCESS THROUGHPUT; PURIFICATION PROCESS; THEORETICAL PLATES;

DISTILLATION; DRUG PRODUCTS; PURIFICATION; THERMOCHEMISTRY; THROUGHPUT;

DISTILLATION COLUMNS;

EID: 77954865919     PISSN: 00981354     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compchemeng.2010.03.019     Document Type: Article

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